N¹-nicotinoyl-N⁴-benzoyl-3-thiosemicarbazide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N¹-nicotinoyl-N⁴-benzoyl-3-thiosemicarbazide
• 英文别名: N(1)-nicotinoyl-N(4)-benzoyl-3-thiosemicarbazide；N-[(pyridine-3-carbonylamino)carbamothioyl]benzamide
• 化学式: C₁₄H₁₂N₄O₂S
• 分子量: 300.341
• InChiKey: LTZGPZJUTIVMRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三氯化铁 、 N¹-nicotinoyl-N⁴-benzoyl-3-thiosemicarbazide 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Singh; Singh, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2001, vol. 40, # 10, p. 1070 - 1075

  摘要：

  DOI：
• 作为产物：
  描述：

  3-吡啶甲酰肼 、 苯甲酰基异硫氰酸酯 以 四氢呋喃 为溶剂， 以83%的产率得到N¹-nicotinoyl-N⁴-benzoyl-3-thiosemicarbazide
  参考文献：
  名称：

  Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity

  摘要：

  A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties. (C) 1998 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(98)00073-1

文献信息

• Preparation of new 5-aroylamino substituted 3-nicotinoyl/isonicotinoyl-1,3,4-thiadiazol-2(3H)-ones with anti-inflammatory activity
  作者：Silvia Schenone、Olga Bruno、Angelo Ranise、Francesco Bondavalli、Walter Filippelli、Giuseppe Falcone、Brunella Piucci、Salvatore Sorrentino

  DOI：10.1016/s0014-827x(98)00073-1

  日期：1998.8

  A series of 1,3,4-thiadiazol-2(3H)-ones (2a-j) with a nicotinoyl/isonicotinoyl group in position 3 and an aroylamino substituent in position 5 of the ring was prepared and evaluated for antipyretic and anti-inflammatory activities. All the title compounds and in particular 2e, 2i and 2j exhibited anti-inflammatory activity and were devoid of antipyretic properties. (C) 1998 Elsevier Science S.A. All rights reserved.
• Singh; Singh, Indian Journal of Chemistry, Section A: Inorganic, Physical, Theoretical and Analytical, 2001, vol. 40, # 10, p. 1070 - 1075
  作者：Singh、Singh

  DOI：——

  日期：——