METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS
申请人:Gebauer Peter
公开号:US20130303768A1
公开(公告)日:2013-11-14
A method for the synthesis of N-substituted 3-acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine.
一种通过将五甲基前体物与一级胺反应合成N-取代3-酰基吡啶化合物的方法。
[EN] AMINOPYRIMIDINES AS SYK INHIBITORS<br/>[FR] AMINOPYRIMIDINES EN TANT QU'INHIBITEURS DE LA SYK
申请人:MERCK SHARP & DOHME
公开号:WO2011075515A1
公开(公告)日:2011-06-23
The present invention provides novel pyrimidine amines of formula (I) which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD and rheumatoid arthritis.
[EN] METHOD AND SUBSTANCES FOR PREPARATION OF N-SUBSTITUTED PYRIDINIUM COMPOUNDS<br/>[FR] PROCÉDÉ ET SUBSTANCES PERMETTANT DE PRÉPARER DES COMPOSÉS DE PYRIDINIUM N-SUBSTITUÉS
申请人:ROCHE DIAGNOSTICS GMBH
公开号:WO2012101095A1
公开(公告)日:2012-08-02
The present invention relates to a method for the synthesis of N-substituted 3- acylated pyridinium compounds by reacting a pentamethine precursor with a primary amine.
本发明涉及一种通过将五甲基前体与一级胺反应合成N-取代的3-酰基吡啶化合物的方法。
1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazoles as 5-hydroxytryptamine-6 ligands
申请人:Wyeth LLC
公开号:US08063053B2
公开(公告)日:2011-11-22
The invention relates to 1-(arylsulfonyl)-4-(piperazin-1-yl)-1H-benzimidazole compounds of the Formula I:
or a tautomer, stereoisomer, or pharmaceutically acceptable salt thereof, wherein the constituent variables are as defined herein, compositions comprising the compounds, and methods for making and using the compounds.
Method and Substances for the Preparation of N-Substituted Pyridinium Compounds
申请人:Heindl Dieter
公开号:US20120190855A1
公开(公告)日:2012-07-26
Methods for the synthesis of N-substituted carboxylated pyridinium compounds by reaction of a pentamethine precursor with a primary amine are provided. In this reaction an N-substituted alkoxycarbonyl pyridinium heterocycle is formed.