3-ethoxybutanoic acid | 19878-71-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-ethoxybutanoic acid
• 英文别名: 3-ethoxy-butyric acid；3-Aethoxy-buttersaeure；β-Aethoxy-buttersaeure；3-ethoxy-butanoic acid
• CAS: 19878-71-8
• 化学式: C₆H₁₂O₃
• 分子量: 132.159
• InChiKey: OPXOAENGHZNGBT-UHFFFAOYSA-N

物化性质

• 沸点：
  207.4±23.0 °C(Predicted)
• 密度：
  1.024±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-ethoxybutanoic acid 生成 巴豆酸 、 乙醇
  参考文献：
  名称：

  Stoermer; Stockmann, Chemische Berichte, 1914, vol. 47, p. 1790

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙氧基-丁腈 在 盐酸 作用下， 生成 3-ethoxybutanoic acid
  参考文献：
  名称：

  Pinner, Chemische Berichte, 1879, vol. 12, p. 2057

  摘要：

  DOI：

文献信息

• TBK/IKK INHIBITOR COMPOUNDS AND USES THEREOF
  申请人：Merck Patent GmbH

  公开号：US20160376283A1

  公开（公告）日：2016-12-29

  The present invention relates to compounds of Formula I and pharmaceutically acceptable compositions thereof, useful as TBK/IKKε inhibitors.

  本发明涉及式I化合物及其药用可接受的组合物，用作TBK/IKKε抑制剂。
• BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS
  申请人：ORION CORPORATION

  公开号：US20160368906A1

  公开（公告）日：2016-12-22

  The present disclosure provides bicyclic heterocyclic derivatives of formula (I), which may be therapeutically useful, more particularly as bromodomain inhibitors; (I), in which R 1 , R 2 , R 3 , R 4 , L 1 , L 2 , Cy 1 , Cy 2 , X, n, and dotted line have the same meaning given in the specification, and pharmaceutically acceptable salts or pharmaceutically acceptable stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders associated as bromodomain inhibitors. The present disclosure also provides preparation of compounds and pharmaceutical formulations comprising at least one of bicyclic heterocyclic derivatives of formula (I), together with a pharmaceutically acceptable carrier, diluent, or excipient.

  本公开提供了公式（I）的双环杂环衍生物，可能在治疗上有用，更具体地作为溴结构域抑制剂；（I）中，R1、R2、R3、R4、L1、L2、Cy1、Cy2、X、n和虚线具有规范中给定的相同含义，以及其在治疗和预防疾病或疾病中有用，特别是在与溴结构域抑制剂相关的疾病或疾病中的使用。本公开还提供了制备化合物和包括至少一种公式（I）的双环杂环衍生物的药物配方，以及药学上可接受的载体、稀释剂或赋形剂。
• Efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base
  作者：Feng Wang、Haijun Yang、Hua Fu、Zhichao Pei

  DOI：10.1039/c2cc37595h

  日期：——

  A novel and efficient copper-catalyzed Michael addition of acrylic derivatives with primary alcohols in the presence of base has been developed. The protocol uses readily available acrylic derivatives and primary alcohols as the starting materials, inexpensive CuCl2 as the catalyst, and the corresponding addition products were obtained in moderate to excellent yields.

  开发了一种新颖且高效的铜催化丙烯酸衍生物与醇类的迈克尔加成反应，该反应在碱的存在下进行。该方法使用容易获得的丙烯酸衍生物和初级醇作为起始材料，以廉价的CuCl2作为催化剂，得到相应的加成产物，产率中等至优良。
• COMPOSITION, FILM, NEAR INFRARED CUT FILTER, LAMINATE, PATTERN FORMING METHOD, SOLID IMAGE PICKUP ELEMENT, IMAGE DISPLAY DEVICE, INFRARED SENSOR, AND COLOR FILTER
  申请人：FUJIFILM Corporation

  公开号：US20180305552A1

  公开（公告）日：2018-10-25

  The composition includes two or more near infrared absorbing compounds having an absorption maximum in a wavelength range of 650 to 1000 nm and having a solubility of 0.1 mass % or lower in water at 23° C., in which the two or more near infrared absorbing compounds include a first near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm, and a second near infrared absorbing compound having an absorption maximum in a wavelength range of 650 to 1000 nm which is shorter than the absorption maximum of the first near infrared absorbing compound, and a difference between the absorption maximum of the first near infrared absorbing compound and the absorption maximum of the second near infrared absorbing compound is 1 to 150 nm.

  该组合物包括两种或更多在波长范围为650到1000纳米具有吸收峰值的近红外吸收化合物，并且在23°C下其在水中的溶解度为0.1质量%或更低。其中，这两种或更多的近红外吸收化合物包括第一种在波长范围为650到1000纳米具有吸收峰值的近红外吸收化合物，以及第二种在波长范围为650到1000纳米具有比第一种近红外吸收化合物吸收峰值更短的吸收峰值的近红外吸收化合物，第一种近红外吸收化合物的吸收峰值与第二种近红外吸收化合物的吸收峰值之间的差值为1到150纳米。
• [EN] TRIAZOLE-CROSSLINKED AND THIOETHER-CROSSLINKED PEPTIDOMIMETIC MACROCYCLES<br/>[FR] MACROCYCLES PEPTIDOMIMÉTIQUES RÉTICULÉS PAR TRIAZOLE ET PAR THIOÉTHER
  申请人：AILERON THERAPEUTICS INC

  公开号：WO2013123267A1

  公开（公告）日：2013-08-22

  Provided herein are peptidomimetic macrocycles and methods of using such macrocycles for the treatment of disease.

  本文提供了肽类模拟大环和使用这种大环治疗疾病的方法。