4-(2-氨基苯基)丁酸 | 145486-67-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-氨基苯基)丁酸
• 英文名称: citrus G
• 英文别名: 4-(2-aminophenyl)butyric acid；γ-(aminophenyl)-butyric acid；4-(2-Amino-phenyl)-buttersaeure；γ-(2-Amino-phenyl)-buttersaeure；4-(2-Aminophenyl)butanoic acid
• CAS: 145486-67-5
• 化学式: C₁₀H₁₃NO₂
• mdl: MFCD09743559
• 分子量: 179.219
• InChiKey: FEJUPMPORLHXGG-UHFFFAOYSA-N

物化性质

• 沸点：
  364.0±17.0 °C(Predicted)
• 密度：
  1.177±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  63.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(2-氨基苯基)丁酸 生成 1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮
  参考文献：
  名称：

  Schroeter et al., Chemische Berichte, 1930, vol. 63, p. 1308,1325

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3,4,5-四氢-2H-1-苯并氮杂卓-2-酮 在 盐酸 作用下， 生成 4-(2-氨基苯基)丁酸
  参考文献：
  名称：

  邻位取代的芳基的分子内反应

  摘要：

  通过使用流动池通过还原水溶液中的芳构氮鎓盐已经产生了邻位取代的芳基。esr光谱表明，相对于自由基中心，在5，6-或6，7-位上含有烯键的自由基通过分别加到5-和6-位上而经历快速环化，从而得到热力学上较不稳定的产物。没有证据表明除了双键的远端。环化的方向主要不是由自由基中心接近烯属碳原子的情况决定的。含有饱和邻位的芳基-取代基通过1，5-分子内氢原子转移进行重排。通过减少合适的槟榔重氮盐分离出重排产物，支持了基于电子共振光谱学研究的结论。

  DOI：

  10.1039/p29750000593

文献信息

• Nitrilases, nucleic acids encoding them and methods for making and using them
  申请人：Diversa Corporation

  公开号：US20040014195A1

  公开（公告）日：2004-01-22

  The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.

  该发明涉及腈酶和编码腈酶的核酸。此外还提供了设计新腈酶的方法以及使用该方法的方法。这些腈酶在较高的pH值和温度下具有增加的活性和稳定性。
• Benzo-fused lactams that promote the release of growth hormone
  申请人：Merck & Co., Inc.

  公开号：US05206235A1

  公开（公告）日：1993-04-27

  There are disclosed certain novel compounds identified as benzo-fused lactams which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to increase the stature of those afflicted with a lack of a normal secretion of natural growth hormone. Growth promoting compositions containing such benzo-fused lactams as the active ingredient thereof are also disclosed.

  已披露了一些新型化合物，被确定为苯并咪唑内酰胺，可促进人类和动物体内生长激素的释放。这种特性可以用于促进食用动物的生长，使可食用肉制品的生产更加高效，在人类身上，可以增加那些缺乏正常分泌天然生长激素的人的身高。还披露了含有苯并咪唑内酰胺作为活性成分的促生长组合物。
• Compositions for the delivery of antigens
  申请人：Emisphere Technologies, Inc.

  公开号：US20020001591A1

  公开（公告）日：2002-01-03

  The present invention relates to compositions and methods for orally delivering antigens. The antigen and an adjuvant are combined with an acylated amino acid or polyamino acid and, a sulfonated amino acids or polyamino acid, or a salt of the foregoing.

  本发明涉及用于口服给药抗原的组合物和方法。将抗原和佐剂与酰化氨基酸或多氨基酸，磺化氨基酸或多氨基酸，或其盐结合。
• Active agent transport systems
  申请人：Emisphere Technologies, Inc.

  公开号：US20010039258A1

  公开（公告）日：2001-11-08

  Methods for transporting a biologically active agent across a cellular membrane or a lipid bilayer. A first method includes the steps of: (a) providing a biologically active agent which can exist in a native conformational state, a denatured conformational state, and an intermediate conformational state which is reversible to the native state and which is conformationally between the native and denatured states; (b) exposing the biologically active agent to a complexing perturbant to reversibly transform the biologically active agent to the intermediate state and to form a transportable supramolecular complex; and (c) exposing the membrane or bilayer to the supramolecular complex, to transport the biologically active agent across the membrane or bilayer. The perturbant has a molecular weight between about 150 and about 600 daltons, and contains at least one hydrophilic moiety and at least one hydrophobic moiety. The supramolecular complex comprises the perturbant non-covalently bound or complexed with the biologically active agent. In the present invention, the biologically active agent does not form a microsphere after interacting with the perturbant. A method for preparing an orally administrable biologically active agent comprising steps (a) and (b) above is also provided as are oral delivery compositions. Additionally, mimetics and methods for preparing mimetics are contemplated.

  跨越细胞膜或脂质双层传输生物活性物质的方法。第一种方法包括以下步骤：（a）提供一种生物活性物质，该生物活性物质可以存在于原生构象状态、变性构象状态和中间构象状态，该中间构象状态可逆转至原生状态，且在构象上介于原生态和变性态之间；（b）将生物活性物质暴露于复合扰动剂中，以可逆地将生物活性物质转变为中间状态，并形成可传输的超分子复合物；（c）将膜或双层暴露于超分子复合物中，以跨越膜或双层传输生物活性物质。扰动剂的分子量介于约150至约600道尔顿之间，并含有至少一个亲水性基团和至少一个疏水性基团。超分子复合物包括非共价地结合或复合的扰动剂和生物活性物质。在本发明中，生物活性物质与扰动剂相互作用后不会形成微球。还提供了一种制备口服生物活性物质的方法，包括上述步骤（a）和（b），以及口服给药组合物。此外，还考虑了类似物和制备类似物的方法。
• Methods and compounds for inhibiting beta-amyloid peptide release and/or its synthesis
  申请人：Audia E. James

  公开号：US20060223761A1

  公开（公告）日：2006-10-05

  Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease Also disclosed pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

  本发明涉及一种抑制β-淀粉样肽释放和/或其合成的化合物，并因此具有在治疗阿尔茨海默病中的用途。本发明还涉及包含抑制β-淀粉样肽释放和/或其合成的化合物的药物组合物，以及使用这种药物组合物在预防和治疗阿尔茨海默病方面的方法。