12-phosphonododecanoic acid | 295792-72-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-phosphonododecanoic acid
• CAS: 295792-72-2
• 化学式: C₁₂H₂₅O₅P
• 分子量: 280.301
• InChiKey: BUKGQBGCJBXIKV-UHFFFAOYSA-N

物化性质

• 沸点：
  484.6±37.0 °C(Predicted)
• 密度：
  1.165±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  12-羟基十二酸 在 盐酸 、 N-溴代丁二酰亚胺(NBS) 、 乙酰氯 、 三苯基膦 作用下， 以 二氯甲烷 为溶剂， 生成 12-phosphonododecanoic acid
  参考文献：
  名称：

  自组装单层中氢键相互作用的 1H 快速 MAS NMR 研究

  摘要：

  通过(1)H快速魔角旋转(MAS)、异核关联(HETCOR)和(1)H双量子(DQ)MAS固态核磁共振实验研究了羧烷基膦酸吸附在金属氧化物上形成的结构. 二酸 HO(2)C(CH(2))(n)PO(3)H(2)（n = 2、3、11 和 15）被吸附在 TiO(2) 和两种类型的 ZrO(2) 上) 平均粒径分别为 20、30 和 5 nm 的粉末。羧烷基膦酸通过膦酸酯基团选择性结合，形成带有侧链羧酸基团的单层。虽然在 TiO(2) 上检测到偶极耦合 P-OH 质子，但 ZrO(2) 上只有孤立的残留 P-OH 基团，反映了膦酸在这两种基材上的相对结合强度。从具有类似单层系统的比较 (1)H MAS NMR 研究中，HO(2)C(CH(2))(7)SH 涂层金纳米粒子，在单层/空气界面的氢键网络被发现是相当无序的，至少对于沉积在非平面基板上的 SAM。而只有氢键同型二聚体发生在散装二酸中，羧酸和膦酸组之间的氢键存在于

  DOI：

  10.1021/ja029008u

文献信息

• Multilayer structure and method for producing same, coating liquid, packaging material, and protective sheet for electronic devices
  申请人：KURARAY CO., LTD.

  公开号：US11214696B2

  公开（公告）日：2022-01-04

  The present invention relates to a multilayer structure including a base (X) and a layer (Y), wherein the layer (Y) includes an aluminum-containing compound (A) and a phosphorus compound (BH) in which a phosphorus atom having at least one hydroxy group and a polar group are bonded via an alkylene chain having 3 to 20 carbon atoms or a polyoxyalkylene chain based on an alkylene having 3 to 20 carbon atoms, and the aluminum-containing compound (A) is a compound (Ab) including a reaction product (D) of an aluminum-containing metal oxide (Aa) and an inorganic phosphorus compound (BI).

  本发明涉及一种多层结构，包括基底（X）和层（Y），其中 层（Y）包括含铝化合物（A）和磷化合物（BH），其中具有至少一个羟基的磷原子和极性基团通过具有 3 至 20 个碳原子的亚烷基链或基于具有 3 至 20 个碳原子的亚烷基的聚氧亚烷基链键合，以及 含铝化合物 (A) 是一种化合物 (Ab)，包括含铝金属氧化物 (Aa) 和无机磷化合物 (BI) 的反应产物 (D)。
• Detection of single nucleotide polymorphisms
  申请人：Xanthon, Inc.

  公开号：US20020182606A1

  公开（公告）日：2002-12-05

  A method determining the presence or absence of a single nucleotide polymorphism at a SNP site in a nucleic acid target. Capture probes are designed, each of which has a different SNP base and a sequence of probe bases on each side of the SNP base. The probe bases are complementary to the corresponding target sequence adjacent to the SNP site. Each capture probe is immobilized on a different electrode having a non-conductive outer layer on a conductive working surface of a substrate. The extent of hybridization between each capture probe and the nucleic acid target is detected by detecting the oxidation-reduction reaction at each electrode, utilizing a transition metal complex. These differences in the oxidation rates at the different electrodes are used to determine whether the selected nucleic acid target has a single nucleotide polymorphism at the selected SNP site.

  一种确定核酸靶标中 SNP 位点是否存在单核苷酸多态性的方法。设计的捕获探针每个都有一个不同的 SNP 碱基和 SNP 碱基两侧的探针碱基序列。探针碱基与 SNP 位点附近的相应靶序列互补。每个捕获探针都固定在不同的电极上，该电极有一个非导电外层，位于基底的导电工作面上。每个捕获探针与核酸靶之间的杂交程度是通过检测每个电极上的氧化还原反应来检测的，使用的是过渡金属复合物。不同电极上氧化率的差异可用于确定所选核酸靶是否在所选 SNP 位点存在单核苷酸多态性。
• Surface plasmon resonance systems and methods having a variable charge density layer
  申请人：——

  公开号：US20040113077A1

  公开（公告）日：2004-06-17

  A device for detecting the presence of a member of a specific binding pair in a sample includes a substrate and a variable charge density layer having a surface adjacent to the substrate and a surface remote from the substrate. A first member of a specific binding pair is on the surface of the variable charge density layer remote from the substrate. The first member interacts with a second member of the specific binding pair present in a sample. The variable charge density layer has a charge carrier density that can be changed by the application of light and/or an electric field, so that a plasmon band is produced by a reflected light source impinging on the variable charge density layer.

  一种用于检测样品中是否存在特异性结合对成员的装置包括一个基底和一个可变电荷密度层，可变电荷密度层具有一个邻近基底的表面和一个远离基底的表面。特异性结合对的第一个成员位于远离基底的可变电荷密度层表面上。第一成员与样品中存在的特异性结合对的第二成员相互作用。可变电荷密度层具有电荷载流子密度，该密度可通过光和/或电场的应用而改变，因此，当反射光源撞击到可变电荷密度层时，就会产生等离子体带。
• Photothermal detection of nucleic acid hybridization
  申请人：North Carolina State University

  公开号：US20040180369A1

  公开（公告）日：2004-09-16

  A nucleic acid hybridization detection assay is carried out at a solid surface. Capture probes comprising single-stranded oligonucleotides are immobilized to a solid substrate surface. In some embodiments using sandwich assay methodology, the capture probes hybridize complementary target nucleic acid sequences, which in turn are bound to detection probes comprising nanoparticle-oligonucleotide conjugates comprising target-complementary oligonucleotides. In some embodiments, detection probes comprise nanoparticles attached to molecules comprising one partner of a ligand-binding pair (e.g., streptavidin), while target sequences comprise the other partner of the ligand-binding pair (e.g., biotin). The solid surface is exposed to light at a wavelength that is absorbed by the nanoparticle, thus eliciting a temperature jump. The heat generated by the nanoparticle excitation is detected by a photothermography method such as infrared thermography.

  在固体表面进行核酸杂交检测试验。由单链寡核苷酸组成的捕获探针固定在固体基底表面。在某些使用夹心检测方法的实施方案中，捕获探针与互补的靶核酸序列杂交，而互补的靶核酸序列又与检测探针结合，检测探针由纳米粒子-寡核苷酸共轭物组成，纳米粒子-寡核苷酸共轭物包括靶互补寡核苷酸。在某些实施方案中，检测探针由纳米颗粒组成，纳米颗粒附着在由配体结合对（例如链霉亲和素）的一个伙伴组成的分子上，而目标序列由配体结合对（例如生物素）的另一个伙伴组成。固体表面暴露在被纳米粒子吸收的波长的光下，从而引起温度跃迁。纳米粒子激发产生的热量可通过红外热成像等光热成像方法检测到。
• Temperature-jump enhanced electrochemical detection of nucleic acid hybridization
  申请人：Franzen Stefan

  公开号：US20050191651A1

  公开（公告）日：2005-09-01

  A nucleic acid hybridization detection assay is carried out at a solid electrode. A solid electrode, such as an indium tin oxide electrode, is modified by single-stranded capture oligonucleotides that are immobilized to the surface of the electrode. Using sandwich assay methodology, complementary target nucleic acid sequences hybridize to the capture oligonucleotides, which are in turn hybridized to a detection probe comprising a nanoparticle. When the assay is carried out in the presence of a redox mediator in solution, the nanoparticle catalyzes the transfer of electrons to the electrode, thus generating a detectable electrical current.

  核酸杂交检测试验在固体电极上进行。固体电极（如氧化铟锡电极）由固定在电极表面的单链捕获寡核苷酸修饰。利用夹心检测方法，互补的目标核酸序列与捕获寡核苷酸杂交，捕获寡核苷酸又与由纳米粒子组成的检测探针杂交。在溶液中有氧化还原介质的情况下进行检测时，纳米粒子会催化电子转移到电极上，从而产生可检测的电流。