N-(4,4-diphenylbutyl)-2-phenylethylamine | 145533-02-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4,4-diphenylbutyl)-2-phenylethylamine
• 英文别名: VUF9004；4,4-diphenyl-N-(2-phenylethyl)butan-1-amine
• CAS: 145533-02-4
• 化学式: C₂₄H₂₇N
• 分子量: 329.485
• InChiKey: DWDOIXWQEFCLAO-UHFFFAOYSA-N

物化性质

• 沸点：
  481.8±34.0 °C(predicted)
• 密度：
  1.024±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4,4-二苯基丁腈 在 lithium aluminium tetrahydride 、 硫酸 、 sodium cyanoborohydride 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 N-(4,4-diphenylbutyl)-2-phenylethylamine
  参考文献：
  名称：

  New prenylamine analogues: synthesis and Ca2+-entry blocking activity

  摘要：

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.

  DOI：

  10.1016/0223-5234(92)90136-o

文献信息

• New prenylamine analogues: synthesis and Ca2+-entry blocking activity
  作者：PM Caldirola、H van der Goot、H Timmerman

  DOI：10.1016/0223-5234(92)90136-o

  日期：1992.9

  The synthesis of a series of diphenylalkylamine derivatives related to prenylamine is reported. The amphetamine group in the prenylamine structure was replaced by other moieties. In addition to substitutions in the aromatic rings, heteroatoms such as sulphur and oxygen were introduced in the chain. The calcium-entry blocking activity was assayed in binding experiments on a guinea-pig brain membrane preparation by displacing [H-3]-nitrendipine.