desaminothyronine | 500-81-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: desaminothyronine
• 英文别名: 3-[4-(4-hydroxy-phenoxy)-phenyl]-propionic acid；3-[4-(4-Hydroxy-phenoxy)-phenyl]-propionsaeure；β-<4-(4'-Hydroxy-phenoxy)-phenyl>-propionsaeure；β-<4-(4-Hydroxy-phenoxy)-phenyl>-propionsaeure；Thyropropionsaeure；3-[4-(4-hydroxyphenoxy)phenyl]propanoic acid
• CAS: 500-81-2
• 化学式: C₁₅H₁₄O₄
• 分子量: 258.274
• InChiKey: QYUVZZKDKOOWPN-UHFFFAOYSA-N

物化性质

• 沸点：
  450.6±35.0 °C(Predicted)
• 密度：
  1.276±0.06 g/cm3(Predicted)
• 熔点：
  161 °C

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  desaminothyronine 在 盐酸 、 乙醇 作用下， 生成 β-<4-(4-Hydroxy-phenoxy)-phenyl>-propionsaeure-aethylester
  参考文献：
  名称：

  57.合成潜在的皮质激素替代物的实验。二苯醚的羟基羰基衍生物及相关化合物

  摘要：

  DOI：

  10.1039/jr9420000347
• 作为产物：
  描述：

  4-(4-methoxy-phenoxy)-trans-cinnamic acid methyl ester 在 Pd/SrCO₃ 、 氢溴酸 、 溶剂黄146 、 乙酸乙酯 作用下， 生成 desaminothyronine
  参考文献：
  名称：

  57.合成潜在的皮质激素替代物的实验。二苯醚的羟基羰基衍生物及相关化合物

  摘要：

  DOI：

  10.1039/jr9420000347

文献信息

• POLYMERIC BIOMATERIALS DERIVED FROM PHENOLIC MONOMERS AND THEIR MEDICAL USES
  申请人：Rutgers, The State University of New Jersey

  公开号：US20130203713A1

  公开（公告）日：2013-08-08

  The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

  本发明提供了新型酚类化合物，包括从酪醇和类似物中衍生的化合物，用作生物相容性聚合物的单体，以及从这些单体酚化合物制备的生物相容性聚合物，包括新型可降解和/或可吸收的聚合物。这些生物相容性聚合物或具有增强生物吸收性和加工性能的聚合物组合物在各种医疗应用中非常有用，例如在医疗器械和控释治疗配方中。该发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。
• Polymeric biomaterials derived from phenolic monomers and their medical uses
  申请人：Rutgers, The State University of New Jersey

  公开号：US09416090B2

  公开（公告）日：2016-08-16

  The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogs, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations. The invention also provides methods for preparing these monomeric phenol compounds and biocompatible polymers.

  本发明提供了新的酚类化合物，包括从酪醇和类似物中衍生出的化合物，作为制备生物相容性聚合物的单体，以及从这些单体酚化合物制备的生物相容性聚合物，包括新的可生物降解和/或可生物吸收聚合物。这些具有增强生物吸收性和加工性的生物相容性聚合物或聚合物组合物在各种医疗应用中有用，例如在医疗器械和控释治疗配方中。本发明还提供了制备这些单体酚化合物和生物相容性聚合物的方法。
• BIOCOMPATIBLE POLYMERS FOR MEDICAL DEVICES
  申请人：Bolikal Durgadas

  公开号：US20100234555A1

  公开（公告）日：2010-09-16

  The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radioopacity and are useful for medical device applications and controlled release therapeutic formulations.
• US8252887B2
  申请人：——

  公开号：US8252887B2

  公开（公告）日：2012-08-28
• US8476399B2
  申请人：——

  公开号：US8476399B2

  公开（公告）日：2013-07-02