5-methoxymethyl-2-methylsulfanyl-pyrimidin-4-ylamine | 98432-25-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 5-methoxymethyl-2-methylsulfanyl-pyrimidin-4-ylamine
• 英文别名: 5-Methoxymethyl-2-methylmercapto-pyrimidin-4-ylamin；5-(Methoxymethyl)-2-(methylthio)pyrimidin-4-amine；5-(methoxymethyl)-2-methylsulfanylpyrimidin-4-amine
• CAS: 98432-25-8
• 化学式: C₇H₁₁N₃OS
• mdl: MFCD09754028
• 分子量: 185.25
• InChiKey: ZQOGUFHMLOLFOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  86.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-甲硫基-4-氨基嘧啶-5-甲醇 在 甲醇 、 氢溴酸 、 溶剂黄146 作用下， 生成 5-methoxymethyl-2-methylsulfanyl-pyrimidin-4-ylamine
  参考文献：
  名称：

  Some Analogs of Toxopyrimidine and Methioprim¹

  摘要：

  DOI：

  10.1021/jo01105a043

文献信息

• Quinolone derivatives as fibroblast growth factor receptor inhibitors
  申请人：Principia Biopharma, Inc.

  公开号：US10294223B2

  公开（公告）日：2019-05-21

  Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  本发明公开了成纤维细胞生长因子抑制剂（FGFR），因此可用于治疗可通过抑制 FGFR 治疗的疾病的化合物。还公开了含有此类化合物的药物组合物和制备此类化合物的工艺。
• Synthesis of 2-Thio Analogs of Thiamine¹
  作者：TAKUO OKUDA、CHARLES C. PRICE

  DOI：10.1021/jo01083a004

  日期：1959.1
• QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS
  申请人：Principia Biopharma, Inc.

  公开号：US20180065960A1

  公开（公告）日：2018-03-08

  Compounds that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.
• Some Analogs of Toxopyrimidine and Methioprim¹
  作者：TAKUO OKUDA、CHARLES C. PRICE

  DOI：10.1021/jo01105a043

  日期：1958.11