N-(2,3-dihydroxypropyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamide | 881015-65-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,3-dihydroxypropyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamide
• 英文别名: N-(2,3-dihydroxypropyl)-4-[3-(trifluoromethyl)diazirin-3-yl]benzamide
• CAS: 881015-65-2
• 化学式: C₁₂H₁₂F₃N₃O₃
• 分子量: 303.241
• InChiKey: PPYRKTJRJXUDCT-UHFFFAOYSA-N

物化性质

• 密度：
  1.56±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  94.3
• 氢给体数：
  3
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  N-(2,3-dihydroxypropyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamide 在 sodium periodate 作用下， 以 甲醇 、 水 、 二甲基亚砜 为溶剂， 反应 3.0h， 生成
  参考文献：
  名称：

  Diol Derivative of (3-Trifluoromethyl)phenyldiazirine for Post-labeling of Photocrosslink

  摘要：

  3-Trifluoromethylphenyldiazirinylated diol derivative was utilized to introduce an aldehyde by periodate oxidation, followed by the formation of a Schiff base with biotin hydrazide on a PVDF membrane for post-labeling of photocrosslinked proteins. The biotin hydrazide was able to post-label the 2.5 x 10(-13) mole of closslinked component for chemiluminescent visualization.

  DOI：

  10.3987/com-05-s(k)4
• 作为产物：
  描述：

  3-氨基-1,2-丙二醇 、 4-[3-(三氟甲基)二氮杂环丙烯-3-基]苯甲酸 N-羟基琥珀酰亚胺酯 以 甲醇 、 乙腈 为溶剂， 反应 2.0h， 以86%的产率得到N-(2,3-dihydroxypropyl)-4-(3-trifluoromethyl-3H-diazirin-3-yl)benzamide
  参考文献：
  名称：

  Diol Derivative of (3-Trifluoromethyl)phenyldiazirine for Post-labeling of Photocrosslink

  摘要：

  3-Trifluoromethylphenyldiazirinylated diol derivative was utilized to introduce an aldehyde by periodate oxidation, followed by the formation of a Schiff base with biotin hydrazide on a PVDF membrane for post-labeling of photocrosslinked proteins. The biotin hydrazide was able to post-label the 2.5 x 10(-13) mole of closslinked component for chemiluminescent visualization.

  DOI：

  10.3987/com-05-s(k)4

文献信息

• Diol Derivative of (3-Trifluoromethyl)phenyldiazirine for Post-labeling of Photocrosslink
  作者：Makoto Hashimoto、Yasumaru Hatanaka

  DOI：10.3987/com-05-s(k)4

  日期：——

  3-Trifluoromethylphenyldiazirinylated diol derivative was utilized to introduce an aldehyde by periodate oxidation, followed by the formation of a Schiff base with biotin hydrazide on a PVDF membrane for post-labeling of photocrosslinked proteins. The biotin hydrazide was able to post-label the 2.5 x 10(-13) mole of closslinked component for chemiluminescent visualization.