2-oxiranylmethyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione | 17620-38-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-oxiranylmethyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione
• 英文别名: 2-oxiranylmethyl-3a,4,7,7a-tetrahydroisoindole-1.3-dione；2-[(Oxiran-2-yl)methyl]-3a,4,7,7a-tetrahydro-1H-isoindole-1,3(2H)-dione；2-(oxiran-2-ylmethyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione
• CAS: 17620-38-1
• 化学式: C₁₁H₁₃NO₃
• 分子量: 207.229
• InChiKey: ZAWQXYPBFKPQLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  49.9
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2925190090

反应信息

• 作为反应物：
  描述：

  2-oxiranylmethyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 8.0h， 以87%的产率得到4-oxiranylmethylhexahydro-1-oxa-4-azacyclopropa[f]indene-3,5-dione
  参考文献：
  名称：

  WO2006/92710

  摘要：

  公开号：
• 作为产物：
  描述：

  环氧氯丙烷 、 1,2,3,6-四氢邻苯二甲酰亚胺 在 potassium carbonate 作用下， 以 异丁醇 为溶剂， 反应 8.0h， 以44%的产率得到2-oxiranylmethyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione
  参考文献：
  名称：

  WO2006/92710

  摘要：

  公开号：

文献信息

• ARYLPIPERAZINE DERIVATIVES AS ADRENERGIC RECEPTOR ANTAGONISTS
  申请人：Salman Mohammad

  公开号：US20090312344A1

  公开（公告）日：2009-12-17

  The present invention relates to α 1 , and/or α 1d adrenergic receptor antagonists, which can function as α 1a and/or α 1d adrenergic receptor antagonist and can be used for the treatment of a disease or disorder mediated through α 1a and/or an adrenergic receptor. Compounds disclosed herein can be used for the treatment of benign prostatic hyperplasia (BPH) and the related symptoms thereof. Further, compounds disclosed herein can be used for the treatment of lower urinary tract symptoms associated with or without BPH. Also provided are processes for preparing such compounds, pharmaceutical compositions thereof, and the methods of treating BPH or related symptoms thereof.

  本发明涉及α1和/或α1肾上腺素受体拮抗剂，其可以作为α1a和/或α1d肾上腺素受体拮抗剂，可用于治疗通过α1a和/或肾上腺素受体介导的疾病或紊乱。本文所披露的化合物可用于治疗良性前列腺增生症（BPH）及其相关症状。此外，本文所披露的化合物可用于治疗与或不伴随BPH的下尿路症状。还提供制备此类化合物的方法，其制药组合物以及治疗BPH或其相关症状的方法。
• RESIN COMPOSITION AND MOLDED ARTICLE FILM AND FIBER EACH COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1445282A1

  公开（公告）日：2004-08-11

  Disclosed are a resin composition comprising a polylactic acid resin and a polyacetal resin, and such a resin composition in which the polylactic acid resin and the polyacetal resin are kept miscible with each other. The resin composition has good moldability, workability, mechanical properties, heat resistance and transparency, and may be worked into moldings, films and fibers for practical use.

  本发明公开了一种由聚乳酸树脂和聚缩醛树脂组成的树脂组合物，以及聚乳酸树脂和聚缩醛树脂保持互溶的树脂组合物。该树脂组合物具有良好的成型性、加工性、机械性能、耐热性和透明性，可加工成模塑件、薄膜和纤维以供实际使用。
• ALIPHATIC POLYESTER RESIN COMPOSITION, METHOD FOR PRODUCTION THEREOF, MOLDED ARTICLE AND FOAMED ARTICLE COMPRISING THE RESIN COMPOSITION
  申请人：UNITIKA LTD.

  公开号：EP1640406A1

  公开（公告）日：2006-03-29

  An aliphatic polyester resin composition is provided which is excellent in heat resistance, moldability and hydrolysis resistance. The aliphatic polyester resin composition comprises a biodegradable polyester resin (A) essentially including an α- and/or β-hydroxycarboxylic acid unit and crosslinked by at least one crosslinking agent (B) selected from the group consisting of (meth)acrylate compounds and polyvalent isocyanate compounds, wherein some or all of carboxyl groups of the resin (A) are blocked by 0.01 to 20 parts by mass of a terminal blocking agent (C) based on 100 parts by mass of the resin (A).

  一种脂肪族聚酯树脂组合物具有优异的耐热性、成型性和抗水解性。脂肪族聚酯树脂组合物包括一种可生物降解的聚酯树脂（A），主要包括一个α-和/或β-羟基羧酸单元，并通过至少一种交联剂（B）交联，交联剂（B）选自（甲基）丙烯酸酯化合物和多价异氰酸酯化合物组成的组，其中树脂（A）的部分或全部羧基被 0.01 至 20 质量份的末端封端剂（C）封端（以 100 质量份的树脂（A）为基准）。
• RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1903077A1

  公开（公告）日：2008-03-26

  A resin composition comprising a polylactic acid-based resin (A) and methacrylic resins (B), wherein the methacrylic resins having at least (a) a difference of 10°C or more in glass transition temperature or (b) a difference of 3% or more in syndiotacticity; it is preferred that at least one of the methacrylic resins (B) is a methacrylic resin having a weight average molecular weight of 50,000 to 450,000, a glass transition temperature of 110°C or higher and a syndiotacticity of 40% or more, and that the resin composition further contains a multilayer structure polymer formed as particles each consisting of a core layer and one or more shell layers covering it (C). A molded article made of said resin composition.

  一种树脂组合物，包括聚乳酸基树脂（A）和甲基丙烯酸树脂（B），其中甲基丙烯酸树脂至少(a)在玻璃化转变温度上相差 10°C 或更多，或(b)在联合活度上相差 3% 或更多；优选至少一种甲基丙烯酸树脂 (B) 是重量平均分子量为 50,000 至 450,000 的甲基丙烯酸树脂，玻璃化温度为 110°C 或更高，辛二酸度为 40% 或更高，并且该树脂组合物还包含一种多层结构聚合物，该聚合物形成为颗粒，每个颗粒由芯层和覆盖在芯层上的一层或多层壳层组成 (C)。由所述树脂组合物制成的模塑制品。
• AROMATIC POLYCARBONATE RESIN COMPOSITION
  申请人：Teijin Chemicals, Ltd.

  公开号：EP2213703A1

  公开（公告）日：2010-08-04

  The object of this invention is to provide a resin composition that contains a polymer obtained from biomass resources and constitutes molded articles excellent in heat resistance, mechanical properties and durable stability, this invention including a resin composition comprising (i) a resin component containing 95 to 5 % by weight of an aromatic polycarbonate (component A) and 5 to 95 % by weight of polylactic acid (component B), (ii) 0.001 to 10 parts by weight, per 100 parts by weight of the resin component, of a phosphoric ester metal salt (component C), and (iii) 0.01 to 5 parts by weight, per 100 parts by weight of the polylactic acid (component B), of a terminal blocker (component F), the stereo-complex crystal content (X) of the following expression (I) being 80 % or more, X%=ΔHb/ΔHa+ΔHbx100 wherein ΔHa and ΔHb are a melting enthalpy (ΔHa) of a crystal melting point that appears at lower than 190°C and a melting enthalpy (ΔHb) of a crystal melting point that appears at 190°C or higher but less than 250°C, respectively, in a temperature-elevation process by a differential scanning calorimeter (DSC), and molded articles thereof.

  本发明的目的是提供一种树脂组合物，该树脂组合物含有一种从生物质资源中获得的聚合物，并构成耐热性、机械性能和持久稳定性极佳的模塑制品，本发明包括一种树脂组合物，该树脂组合物包括 (i) 含有 95-5%（按重量计）芳香族聚碳酸酯（组分 A）和 5-95%（按重量 计）聚乳酸（组分 B）的树脂组分、 (ii) 以每 100 份树脂组分重量计，含 0.001 至 10 份磷酸酯金属盐（组分 C），和 (iii) 以每 100 份聚乳酸（组分 B）的重量计，0.01 至 5 份末端封端剂（组分 F）、 以下表达式（I）中立体络合物晶体含量（X）为 80%或以上，X%=ΔHb/ΔHa+ΔHbx100 其中，ΔHa 和 ΔHb 分别是在差示扫描量热仪 (DSC) 的升温过程中，出现在低于 190°C 的晶体熔点的熔化焓 (ΔHa)，以及出现在 190°C 或更高但低于 250°C 的晶体熔点的熔化焓 (ΔHb)。