bis-(1-chloro-1,2,2-trimethyl-propyl)-diazene | 29540-63-4

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: bis-(1-chloro-1,2,2-trimethyl-propyl)-diazene
• 英文别名: Bis(2-chloro-3,3-dimethylbutan-2-yl)diazene；bis(2-chloro-3,3-dimethylbutan-2-yl)diazene
• CAS: 29540-63-4
• 化学式: C₁₂H₂₄Cl₂N₂
• 分子量: 267.242
• InChiKey: HIXCYMVGOCFLMJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  24.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile 、 bis-(1-chloro-1,2,2-trimethyl-propyl)-diazene 在 氯化锑(V) 作用下， 以 二氯甲烷 为溶剂， 反应 2.17h， 生成
  参考文献：
  名称：

  Synthesis and Antiviral Activity of 1,5-and 1,3-Dialkyl-1,2,4-triazoleC-Nucleosides Derived from 1-(Chloroalkyl)-1-aza-2-azoniaallene Salts

  摘要：

  Reactions of alpha,alpha'-dichloroazo compounds 2 with SbCl5 gave 1-(chloroalkyl)-1-aza-2-azoniaallene salts 3 as reactive intermediates. Cycloadditions of 3 with the ribofuranosyl cyanide 4 afforded the beta-D-ribofuranosyl-1,2,4-triazolium salts 5, which rearranged spontaneously to salts 6. Hydrolysis of 6 gave the 1,2,4-triazole C-nucleosides 7, which yielded the free nucleosides 8 after deblocking. Analogously, 12 was prepared from the cycloaddition of 4 with the alpha-chloroazo compound 10 in the presence of SbCl5. Deblocking of 12 with sodium methoxide afforded 13. Compounds 8a,b,e,f and 13 were tested against HIV-1, HIV-2, HSV-1 and HSV-2 and were found to be inactive.

  DOI：

  10.1080/07328319908044859
• 作为产物：
  描述：

  3,3-Dimethyl-2-butanonazin 在 氯 作用下， 以 Petroleum ether 为溶剂， 生成 bis-(1-chloro-1,2,2-trimethyl-propyl)-diazene
  参考文献：
  名称：

  Duismann,W. et al., Justus Liebigs Annalen der Chemie, 1974, p. 1348 - 1356

  摘要：

  DOI：

文献信息

• A new synthesis of t-azoalkanes
  作者：Werner Duismann、Mans-Dieter Beckhaus、Christoph Rüchardt

  DOI：10.1016/s0040-4039(01)82189-4

  日期：1974.1
• Duismann,W. et al., Justus Liebigs Annalen der Chemie, 1974, p. 1348 - 1356
  作者：Duismann,W. et al.

  DOI：——

  日期：——
• Synthesis and Antiviral Activity of 1,5-and 1,3-Dialkyl-1,2,4-triazole<i>C</i>-Nucleosides Derived from 1-(Chloroalkyl)-1-aza-2-azoniaallene Salts
  作者：Yaseen A. Al-soud、Wasfi A. Al-masoudi、Rajab Abu El-halawa、Najim Al-masoudi

  DOI：10.1080/07328319908044859

  日期：1999.9

  Reactions of alpha,alpha'-dichloroazo compounds 2 with SbCl5 gave 1-(chloroalkyl)-1-aza-2-azoniaallene salts 3 as reactive intermediates. Cycloadditions of 3 with the ribofuranosyl cyanide 4 afforded the beta-D-ribofuranosyl-1,2,4-triazolium salts 5, which rearranged spontaneously to salts 6. Hydrolysis of 6 gave the 1,2,4-triazole C-nucleosides 7, which yielded the free nucleosides 8 after deblocking. Analogously, 12 was prepared from the cycloaddition of 4 with the alpha-chloroazo compound 10 in the presence of SbCl5. Deblocking of 12 with sodium methoxide afforded 13. Compounds 8a,b,e,f and 13 were tested against HIV-1, HIV-2, HSV-1 and HSV-2 and were found to be inactive.