3,5,6-trimethyl-2(1H)-pyridone | 66727-76-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3,5,6-trimethyl-2(1H)-pyridone
• 英文别名: 3,5,6-trimethyl-2-pyridone；3,5,6-Trimethylpyridin-2(1H)-one；3,5,6-trimethyl-1H-pyridin-2-one
• CAS: 66727-76-2
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: FFLHBPRFUHVYHR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3,5,6-trimethyl-2(1H)-pyridone 在 三氯氧磷 作用下， 反应 5.0h， 以65%的产率得到2-氯-3,5,6-三甲基吡啶
  参考文献：
  名称：

  Mittelbach; Schmidt; Uray, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1988, vol. 42, # 8, p. 524 - 529

  摘要：

  DOI：
• 作为产物：
  描述：

  2,5-二甲基吡啶 在 正丁基锂 、 1,3,5-三溴-1,3,5-噻嗪烷-2,4,6-三酮 、 硫酸 作用下， 以 四氢呋喃 、 甲醇 、 正己烷 、 水 为溶剂， 反应 8.33h， 生成 3,5,6-trimethyl-2(1H)-pyridone
  参考文献：
  名称：

  Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions

  摘要：

  In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic molecules represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble molecules that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These molecules in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions.

  DOI：

  10.1021/jm4016137

文献信息

• MITTELBACH, MARTIN;SCHMIDT, HANS-WERNER;URAY, GEORG;JUNEK, HANS;LAMM, BO;+, ACTA CHEM. SCAND. B, 42,(1988) N 8, C. 524-529
  作者：MITTELBACH, MARTIN、SCHMIDT, HANS-WERNER、URAY, GEORG、JUNEK, HANS、LAMM, BO、+

  DOI：——

  日期：——
• POLYNUCLEOTIDE MOLECULES AND USES THEREOF
  申请人：MODERNA THERAPEUTICS, INC.

  公开号：US20160264614A1

  公开（公告）日：2016-09-15

  The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.
• CHEMICAL COMPOUNDS
  申请人：GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED

  公开号：US20200255428A1

  公开（公告）日：2020-08-13

  Compounds, specifically hepatitis B virus and/or hepatitis D virus inhibitors, more specifically compounds that inhibit HBe antigen and HBs antigen in a subject, for the treatment of viral infections, and methods of preparing and using such compounds.
• US8653069B2
  申请人：——

  公开号：US8653069B2

  公开（公告）日：2014-02-18
• [EN] POLYNUCLEOTIDE MOLECULES AND USES THEREOF<br/>[FR] MOLÉCULES POLYNUCLÉOTIDIQUES ET LEURS UTILISATIONS
  申请人：MODERNA THERAPEUTICS INC

  公开号：WO2015051173A2

  公开（公告）日：2015-04-09

  The present disclosure provides alternative nucleosides, nucleotides, and polynucleotides, and methods of use thereof.