tetra-n-pentyl-3,7-diaminophenothiazin-5-ium bromide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: tetra-n-pentyl-3,7-diaminophenothiazin-5-ium bromide
• 英文别名: 3,7-bis(dipentylamino)phenothiazin-5-ium bromide；[7-(dipentylamino)phenothiazin-3-ylidene]-dipentylazanium;bromide
• 化学式: Br*C₃₂H₅₀N₃S
• 分子量: 588.739
• InChiKey: WYTWDXOGHCZQEU-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  5.74
• 重原子数：
  37
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tetra-n-pentyl-3,7-diaminophenothiazin-5-ium bromide 在 ammonium hydroxide 、 silver nitrate 作用下， 以 水 为溶剂， 反应 1.0h， 生成 7-(dipentylamino)-3H-phenothiazin-3-one
  参考文献：
  名称：

  [EN] MULTIFUNCTIONAL RADICAL QUENCHERS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION
  [FR] EXTINCTEURS DE LUMINESCENCE RADICAUX MULTIFONCTIONNELS POUR LE TRAITEMENT D'UN DYSFONCTIONNEMENT MITOCHONDRIAL

  摘要：

  公开号：

  WO2012138713A3
• 作为产物：
  描述：

  吩噻嗪 在 溴 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 生成 tetra-n-pentyl-3,7-diaminophenothiazin-5-ium bromide
  参考文献：
  名称：

  Phenothiazinium–fluoroquinolone drug conjugates

  摘要：

  Synthesis and antibacterial screening of a homologous series of 3-dialkylaminophenothiazinium-7-norfloxacin conjugates was carried out alongside a corresponding series of symmetrical methylene blue derivatives. The norfloxacin conjugates maintained typical methylene blue derivative photoproperties, such as long wavelength absorption, but produced no measurable singlet oxygen in the standard assay and provided no significant increase in the magnitude of photoantibacterial action, this being similar to the methylene blue homologues, although both the conjugates and homologues were considerably more active than methylene blue itself both against Staphylococcus aureus and Escherichia coli. DNA binding via intercalation was considerably greater for the series of norfloxacin conjugates than for the methylene blue homologues. (C) 2009 Elsevier B. V. and the International Society of Chemotherapy. All rights reserved.

  DOI：

  10.1016/j.ijantimicag.2009.11.022

文献信息

• Multifunctional Radical Quenchers For The Treatment Of Mitochondrial Dysfunction
  申请人：Hecht Sidney

  公开号：US20140038963A1

  公开（公告）日：2014-02-06

  The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

  本公开提供了一种识别多功能自由基清除剂的治疗剂的方法。还提供了式(I)、(II)或(II-A)的化合物及其药学上可接受的盐、包含这些化合物的组合物和使用这些化合物的方法，例如用于治疗或抑制与线粒体功能下降导致ATP产生减少和/或氧化应激和/或脂质过氧化相关的疾病。
• Multifunctional radical quenchers for the treatment of mitochondrial dysfunction
  申请人：Hecht Sidney

  公开号：US09102626B2

  公开（公告）日：2015-08-11

  The present disclosure provides methods for identifying therapeutic agents that are multifunctional radical quenchers. It also provides compounds of formula (I), (II), or (II-A): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.

  本公开提供了识别多功能自由基清除剂的治疗剂的方法。它还提供了公式(I)、(II)或(II-A)的化合物及其药学上可接受的盐、包含这些化合物的组合物以及使用这些化合物治疗或抑制与减少线粒体功能、导致ATP产生减少和/或氧化应激和/或脂质过氧化有关的疾病的方法。
• MULTIFUNCTIONAL RADICAL QUENCHERS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION
  申请人：Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University

  公开号：EP2694478A2

  公开（公告）日：2014-02-12
• METHYLENE VIOLET ANALOGS AS MULTIFUNCTIONAL RADICAL QUENCHERS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION
  申请人：Arizona Board of Regents, a Body Corporate of the State of Arizona acting for and on behalf of Arizona State University

  公开号：EP2694478B1

  公开（公告）日：2018-08-22
• US9102626B2
  申请人：——

  公开号：US9102626B2

  公开（公告）日：2015-08-11