pentafluorophenyl 5-azidovalerate | 1254560-90-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 英文名称: pentafluorophenyl 5-azidovalerate
• 英文别名: 2,3,4,5,6-Pentafluorophenyl 5-azidopentanoate；(2,3,4,5,6-pentafluorophenyl) 5-azidopentanoate
• CAS: 1254560-90-1
• 化学式: C₁₁H₈F₅N₃O₂
• 分子量: 309.195
• InChiKey: NZJMFKWJWLLQFI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.77
• 重原子数：
  21.0
• 可旋转键数：
  6.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  75.06
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  pentafluorophenyl 5-azidovalerate 在 吡啶 、 甲醇 、 copper(ll) sulfate pentahydrate 、 sodium ascorbate 、 lithium hydroxide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  Exploring divalent conjugates of 5-N-acetyl-neuraminic acid as inhibitors of coxsackievirus A24 variant (CVA24v) transduction

  摘要：

  柯萨奇病毒A24变种（CVA24v）是导致多次爆发和两次高度传染性眼部感染急性出血性结膜炎（AHC）的病毒。

  DOI：

  10.1039/d1ra08968d
• 作为产物：
  描述：

  5-叠氮基戊酸 、 三氟乙酸五氟苯酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 以43 mg的产率得到pentafluorophenyl 5-azidovalerate
  参考文献：
  名称：

  Direct Measurement of Cathepsin B Activity in the Cytosol of Apoptotic Cells by an Activity-Based Probe

  摘要：

  Cells control their own death through a program termed apoptosis, which is indispensable for development and homeostasis in all metazoans. Lysosomal cysteine proteases are not normally thought of as participating in apoptosis; however, recent reports have shown that the cathepsin proteases can be released from the lysosome during apoptosis, where they can participate in cell death. We report here the development of an activity-based probe that, under optimized conditions, reports on cathepsin B activity only in apoptotic cells by reading out the release of cathepsin B from the lysosomes. Biochemical characterization of apoptosis in cells from cathepsin B null mice shows delayed and suboptimal activation of caspases. Our data further supports a role for cathepsin B in the cytosol as a positive regulator of a cell death feed-forward loop and provides a chemical tool for future investigations.

  DOI：

  10.1016/j.chembiol.2009.07.011

文献信息

• IMMUNOMODULATING POLYNUCLEOTIDES, ANTIBODY CONJUGATES THEREOF, AND METHODS OF THEIR USE
  申请人：SOLSTICE BIOLOGICS, LTD.

  公开号：US20180312536A1

  公开（公告）日：2018-11-01

  Immunomodulating polynucleotides are disclosed. The immunomodulating polynucleotides may contain 5-modified uridine, 5-modified cytidine, a total of from 6 to 16 nucleotides, and/or one or more abasic spacers and/or internucleoside phosphotriesters. Also disclosed are conjugates containing a targeting moiety and one or more immunomodulating polynucleotides. The immunomodulating polynucleotides and conjugates may further contain one or more auxiliary moieties. Also disclosed are compositions containing the immunomodulating polynucleotides or the conjugates containing one or more stereochemically enriched internucleoside phosphorothioates. Further disclosed are pharmaceutical compositions containing the immunomodulating polynucleotides or the conjugates and methods of their use.

  免疫调节多核苷酸被披露。这些免疫调节多核苷酸可能包含5-修饰尿苷、5-修饰胞苷、总共6到16个核苷酸，和/或一个或多个缺失间隔子和/或核苷酸间磷三酯。还披露了含有靶向基团和一个或多个免疫调节多核苷酸的结合物。这些免疫调节多核苷酸和结合物可能进一步包含一个或多个辅助基团。还披露了含有这些免疫调节多核苷酸或含有一个或多个立体化富集的核苷酸间磷硫酸酯的结合物的组合物。进一步披露了含有这些免疫调节多核苷酸或结合物的药物组合物以及它们的使用方法。
• WO2020081744A5
  申请人：——

  公开号：WO2020081744A5

  公开（公告）日：2022-10-21