7-[2-[Bis(pyridin-2-ylmethyl)amino]ethylamino]-4-(trifluoromethyl)chromen-2-one | 1432733-48-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[2-[Bis(pyridin-2-ylmethyl)amino]ethylamino]-4-(trifluoromethyl)chromen-2-one
• 英文别名: 7-[2-[bis(pyridin-2-ylmethyl)amino]ethylamino]-4-(trifluoromethyl)chromen-2-one
• CAS: 1432733-48-6
• 化学式: C₂₄H₂₁F₃N₄O₂
• 分子量: 454.452
• InChiKey: VUBMBCQXOHNMLQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  67.4
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为产物：
  描述：

  香豆素 151 在 吡啶 、 硫酸 、 potassium carbonate 、 caesium carbonate 、 potassium iodide 作用下， 以 二氯甲烷 、 乙腈 为溶剂， 反应 32.0h， 生成 7-[2-[Bis(pyridin-2-ylmethyl)amino]ethylamino]-4-(trifluoromethyl)chromen-2-one
  参考文献：
  名称：

  Coumarin-based novel fluorescent zinc ion probe in aqueous solution

  摘要：

  A novel coumarin-derived fluorescent probe, FCP, was designed for Zn2+ quantification based on the photo-induced electron transfer (PET) mechanism. This probe selectively and sensitively detects Zn2+ in aqueous solution with wide pH range. Large fluorescence enhancement (13-fold) was observed upon the addition of Zn2+. FCP also displays excellent cell permeability in HeLa cell model and very low cytotoxicity to HEK-293 cell model. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.03.032

文献信息

• Coumarin-based novel fluorescent zinc ion probe in aqueous solution
  作者：Jun Li、Chun-Fang Zhang、Ze-Zhong Ming、Ge-Fei Hao、Wen-Chao Yang、Guang-Fu Yang

  DOI：10.1016/j.tet.2013.03.032

  日期：2013.6

  A novel coumarin-derived fluorescent probe, FCP, was designed for Zn2+ quantification based on the photo-induced electron transfer (PET) mechanism. This probe selectively and sensitively detects Zn2+ in aqueous solution with wide pH range. Large fluorescence enhancement (13-fold) was observed upon the addition of Zn2+. FCP also displays excellent cell permeability in HeLa cell model and very low cytotoxicity to HEK-293 cell model. (C) 2013 Elsevier Ltd. All rights reserved.