4-nitrophenyl butanol | 157561-07-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-nitrophenyl butanol
• 英文别名: 4-nitrophenylbutanol；1-(4-nitrophenyl)butan-1-ol
• CAS: 157561-07-4
• 化学式: C₁₀H₁₃NO₃
• 分子量: 195.218
• InChiKey: NIQBOWXIDQFSLP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  66
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-nitrophenyl butanol 在 氧气 、 异丁醛 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 7.0h， 以96%的产率得到1-(4-硝基苯基)丁烷-1-酮
  参考文献：
  名称：

  Process for preparing encapsulated metalloporphyrin catalyst and process for oxidation of alcohols

  摘要：

  本发明涉及一种聚苯乙烯包埋的配方I的金属卟啉催化剂，其中R1、R2和R3分别选自烷基、卤素、硝基和氨基等基团，M为选自Fe、Co、Ni、Mn、Cu、Ru、Pt和Pd的金属原子，并且涉及其在醇的氧化中的应用。

  公开号：

  US20060167313A1

文献信息

• .alpha.-branched anilines, toluenes, and analogs thereof as factor Xa
  申请人：DuPont Pharmaceuticals Company

  公开号：US05942544A1

  公开（公告）日：1999-08-24

  The present application describes m-amidino phenyl analogs of formula I: ##STR1## wherein D can be amidino and E can be phenyl, which are useful as inhibitors of factor Xa.

  本申请描述了式I的m-氨基甘氨酰苯类似物：##STR1## 其中D可以是氨基甘氨酰，E可以是苯基，它们可用作因子Xa的抑制剂。
• Indole derivatives
  申请人：Friess Thomas

  公开号：US20060063812A1

  公开（公告）日：2006-03-23

  The present invention relates to the compounds of formula I: their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, compositions containing such compounds and their manufacture, as well as the use of such compounds in the control or prevention of illnesses such as cancer.

  本发明涉及式I的化合物：它们的药用盐、对映体形式、二对映异构体和混合物，上述化合物的制备，含有这种化合物的组合物及其制备，以及这种化合物在控制或预防癌症等疾病中的应用。
• [EN] NOVEL ANILINE DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS<br/>[FR] NOUVEAUX DERIVES D'ANILINE, LEUR FABRICATION ET LEUR UTILISATION EN TANT QU'AGENTS PHARMACEUTIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004096796A1

  公开（公告）日：2004-11-11

  Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是公式(I)的化合物及其药学上可接受的盐、对映体形式、二对映异构体和混合物，上述化合物的制备，含有它们的药物和其制造，以及上述化合物在控制或预防癌症等疾病中的使用。
• Aniline derivatives, their manufacture and use as pharmaceutical agents
  申请人：——

  公开号：US20040254217A1

  公开（公告）日：2004-12-16

  Compounds of formula (I) 1 are useful in the therapy and/or prevention of illnesses with known over-expression of receptor tyrosine kinases of the HER-family like HER-2 and EGFR (HER-1). Accordingly, these compounds are useful for the treatment of diseases such as cancer in humans or animals.

  式(I)1的化合物在治疗和/或预防已知过度表达HER家族受体酪氨酸激酶的疾病（如HER-2和EGFR（HER-1））方面是有用的。因此，这些化合物对于治疗人类或动物的癌症等疾病是有用的。
• Compounds of formula [1,1'-biphenyl]-2-carboxylic acid, 2'-[[[(substituted)phenyl]-(substituted)amino]carbonyl]-, pharmaceutical compositions comprising the compounds, and a process for preparing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0206567A2

  公开（公告）日：1986-12-30

  The present invention provides various novel diphenic acid monoamide compounds of the formula Also provided are novel pharmaceutical compositions comprising . the compounds and novel methods for synthesising the compounds. The novel diphenic acid monoamides of the present invention areleukotriene antagonists, 5-lipoxygenase inhibitors, and mediator release inhibitors providing activity useful for treating asthma, allergies, cardiovascular diseases, migraines, and immunoinflammatory conditions.

  本发明提供了各种新型二苯基酸单酰胺化合物，其式为 还提供了包含......这些化合物的新型药物组合物和合成这些化合物的新型方法。本发明的新型二苯甲酸单酰胺类化合物是白三烯拮抗剂、5-脂氧合酶抑制剂和介质释放抑制剂，具有治疗哮喘、过敏、心血管疾病、偏头痛和免疫炎症的活性。