5-{5-[3-(trifluoromethyl)phenyl]-2-furylmethylene}-1,3-thiazolidine-2,4-dione | 330855-51-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{5-[3-(trifluoromethyl)phenyl]-2-furylmethylene}-1,3-thiazolidine-2,4-dione
• 英文别名: 5-[5-(3-(trifluoromethyl)phenyl)fur-2-ylmethylene]-1,3-thiazolidine-2,4-dione；5-[5-(3-(trifluoromethyl)phenyl)fur-2-ylmethylene]thiazolidine-2,4-dione；5-[[5-[3-(trifluoromethyl)phenyl]furan-2-yl]methylidene]-1,3-thiazolidine-2,4-dione
• CAS: 330855-51-1
• 化学式: C₁₅H₈F₃NO₃S
• 分子量: 339.295
• InChiKey: XKNSKYLKHDXQLT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  84.6
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-{5-[3-(trifluoromethyl)phenyl]-2-furylmethylene}-1,3-thiazolidine-2,4-dione 在 氢氧化钾 、 锂硼氢 、 盐酸 、 水 作用下， 以 四氢呋喃 、 吡啶 为溶剂， 反应 3.0h， 以17%的产率得到5-[5-(3-(trifluoromethyl)phenyl)fur-2-ylmethyl]thiazolidine-2,4-dione
  参考文献：
  名称：

  Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening

  摘要：

  Phenylfurylmethylthiazolidine-2,4-dione和phenylthienylmethylthiazolidine-2,4-dione的化合物（1式）：对促进和/或诱导和/或刺激角质质物的色素沉着以及限制它们的脱色和/或变白特别有用，尤其是预防和/或限制人类角质纤维的白发。

  公开号：

  US20070077215A1
• 作为产物：
  描述：

  2,4-噻唑烷二酮 、 5-[3-(三氟甲基)苯基]糠醛 以 aq. acetate buffer 为溶剂， 生成 5-{5-[3-(trifluoromethyl)phenyl]-2-furylmethylene}-1,3-thiazolidine-2,4-dione
  参考文献：
  名称：

  Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation

  摘要：

  化合物1和12被确定为外切酶的水解酶选择性抑制剂或环化酶选择性抑制剂，它们的IC₅₀值分别为4.0和20.8毫摩尔。这两种化合物促进了细胞NAD+水平和γ干扰素的增加体外。

  DOI：

  10.1039/d1ra06266b

文献信息

• Administration of novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds for stimulating or inducing the growth of keratinous fibers and/or slowing loss thereof
  申请人：Boulle Christophe

  公开号：US20070078175A1

  公开（公告）日：2007-04-05

  Novel phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds having the following formula and the salts or their solvates thereof: are useful for stimulating or inducing the growth of keratinous fibers and/or slowing down their loss and/or increasing their density and/or improving their appearance, and also for caring for or making up keratinous fibers, e.g., for caring for or making up the hair or eyelashes.

  具有以下公式及其盐或溶剂化合物的新颖苯基呋喃甲基噻唑烷-2,4-二酮和苯基噻吩甲基噻唑烷-2,4-二酮，可用于刺激或诱导角质形成纤维的生长和/或减缓它们的脱落和/或增加它们的密度和/或改善它们的外观，也可用于护理或化妆角质形成纤维，例如护理或化妆头发或睫毛。
• Selective targeting of CD38 hydrolase and cyclase activity as an approach to immunostimulation
  作者：Thomas Z. Benton、Catherine M. Mills、Jonathan M. Turner、Megan J. Francis、Dalan J. Solomon、Pieter B. Burger、Yuri K. Peterson、Nathan G. Dolloff、André S. Bachmann、Patrick M. Woster

  DOI：10.1039/d1ra06266b

  日期：——

  Compounds 1 and 12 were identified as hydrolase- or cyclase-selective inhibitors of the ectoenzyme with IC₅₀ values of 4.0 and 20.8 mM, respectively. Both compounds promoted increases in cellular NAD+ levels and interferon γ in vitro.

  化合物1和12被确定为外切酶的水解酶选择性抑制剂或环化酶选择性抑制剂，它们的IC₅₀值分别为4.0和20.8毫摩尔。这两种化合物促进了细胞NAD+水平和γ干扰素的增加体外。
• Administration of phenylfurymethylthiazolidine-2,4-dione or phenylthienymethylthiazolidine-2,4-dione compounds for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening
  申请人：Boulle Christophe

  公开号：US20070077215A1

  公开（公告）日：2007-04-05

  Phenylfurylmethylthiazolidine-2,4-dione and phenylthienylmethylthiazolidine-2,4-dione compounds of formula (1): are useful for promoting and/or inducing and/or stimulating the pigmentation of keratinous substances and/or limiting their depigmentation and/or their whitening and more particularly for preventing and/or limiting canities of human keratinous fibers.

  Phenylfurylmethylthiazolidine-2,4-dione和phenylthienylmethylthiazolidine-2,4-dione化合物（公式（1））对促进和/或诱导和/或刺激角质蛋白物质的色素沉淀以及限制它们的脱色和/或变白特别有用，更特别地预防和/或限制人类角质纤维的白发。