3-methoxybenzyl 2,2-dimethylpropanoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methoxybenzyl 2,2-dimethylpropanoate
• 英文别名: 3-methoxybenzyl pivalate；(3-Methoxyphenyl)methyl 2,2-dimethylpropanoate
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: FKYYHORUYMMCQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-methoxybenzyl 2,2-dimethylpropanoate 生成 1-甲氧基-3-(甲氧基甲基)苯
  参考文献：
  名称：

  Hilborn J. W., MacKnight E., Pincock J. A., Wedge P. J., J. Amer. Chem. Soc, 116 (1994) N 8, S 3337- 3346

  摘要：

  DOI：
• 作为产物：
  描述：

  间甲氧基苯甲醇 、 三甲基乙酸酐 在 iron(III) chloride 作用下， 以 neat (no solvent) 为溶剂， 生成 3-methoxybenzyl 2,2-dimethylpropanoate
  参考文献：
  名称：

  A Mild Ni/Cu-Catalyzed Silylation via C–O Cleavage

  摘要：

  A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or benzyl alcohols is described. This transformation is characterized by its wide scope and mild conditions, providing a direct access to synthetically versatile silylated compounds. The protocol allows for the coupling of C(sp(2))-O and even C(sp(3))-O bonds with similar efficiency.

  DOI：

  10.1021/ja412107b

文献信息

• Hypervalent iodine oxidation of phenol derivatives using a catalytic amount of 4-iodophenoxyacetic acid and Oxone® as a co-oxidant
  作者：Takayuki Yakura、Masanori Omoto、Yû Yamauchi、Yuan Tian、Ayaka Ozono

  DOI：10.1016/j.tet.2010.04.124

  日期：2010.7

  Reaction of p-substituted phenols 2 with a catalytic amount of 4-iodophenoxyacetic acid (1) and Oxone® as a co-oxidant in tetrahydrofuran (THF) or 1,4-dioxane–water gave the corresponding p-quinols 3 in excellent yields. Reaction of p-dialkoxyarenes 4 in 2,2,2-trifluoroethanol–water gave the corresponding p-quinones 5 in excellent yield without purification. These reactions provide efficient and practical

  的反应p取代的酚2用4- iodophenoxyacetic酸（催化剂量1）过硫酸氢钾®如四氢呋喃（THF）的共氧化剂或1,4-二恶烷-水，得到相应的p -quinols 3以优良产率。的反应p -dialkoxyarenes 4在2,2,2-三氟乙醇-水，得到相应的p -quinones 5的优良率，无需纯化。这些反应为由对位取代的苯酚和对位苯甲酸制备对苯二酚和对苯醌提供了有效而实用的方法。-二烷氧基芳烃。该醌合成用于德国小att Blattella germanica的性信息素blattellaquinone（13）的合成。
• SUBSTITUTED IMIDAZOLES
  申请人：CHUBB NATHAN ANTHONY LOGAN

  公开号：US20070167506A1

  公开（公告）日：2007-07-19

  This invention relates to a range of alpha substituted 2-benzyl substituted imidazole compounds and pharmaceutically acceptable salts and solvates thereof, to compositions comprising such compounds, processes for their synthesis and their use as parasiticides.

  本发明涉及一系列α取代的2-苄基取代咪唑化合物及其药用可接受盐和溶剂化合物，包括这些化合物的组合物、合成过程以及它们作为驱虫剂的用途。
• Process for preparing a carbapenem antibiotic
  申请人：JOHNSON MATTHEY PUBLIC LIMITED COMPANY

  公开号：US10011603B2

  公开（公告）日：2018-07-03

  A process for the preparation of a carbapenem, includes the step of treating a solution of a protected carbapenem with hydrogen gas in the presence of a heterogeneous catalyst to form the carbapenem, wherein the heterogeneous catalyst includes at least two platinum group metals.

  一种制备碳青霉烯类的工艺，包括在异相催化剂存在下用氢气处理受保护的碳青霉烯类溶液以形成碳青霉烯类的步骤，其中异相催化剂包括至少两种铂族金属。
• Photochemistry of Substituted Benzyl Acetates and Benzyl Pivalates: A Reinvestigation of Substituent Effects
  作者：J. W. Hilborn、E. MacKnight、J. A. Pincock、P. J. Wedge

  DOI：10.1021/ja00087a020

  日期：1994.4

  The photosolvolysis reactions, in methanol, of six substituted benzyl acetates (7a-f) and benzyl pivalates (8a-f) were studied. Five major benzylic products were formed from two critical intermediates. The ethers (9) were formed from the ion pair, 15, and all of the other products (10-14) were formed from the radical pair, 16. Quenching studies showed that only excited singlet state reactivity was important. The product yields were found to be highly substituent dependent. For instance, for the acetate esters, the yield of ether (9) varied from 2% for X = 4-OCH3 to 32% for X = 3-OCH3. Most of the differences in the yields could be attributed to ground state processes that occur after bond cleavage. The important competition is between electron transfer, converting the radical pair to the ion pair, and decarboxylation of RCO(2)(.). The rates of electron transfer are shown to fit Marcus theory in both the normal and inverted regions. Direct heterolytic cleavage to form the ion pair is of minimal importance.
• Pincock J.A., Wedge P.J., J. Org. Chem., 59 (1994) N 19, 5587-5595
  作者：Pincock J.A., Wedge P.J.

  DOI：——

  日期：——