4,6-dimethyl-2-oxopyridine-3-carbonitrile potassium salt | 39088-02-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4,6-dimethyl-2-oxopyridine-3-carbonitrile potassium salt
• 英文别名: 4,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carbonitrile; potassium salt
• CAS: 39088-02-3
• 化学式: C₈H₇N₂O*K
• 分子量: 186.255
• InChiKey: HPMVCVOZMHNWOO-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.35
• 重原子数：
  12.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.74
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4,6-dimethyl-2-oxopyridine-3-carbonitrile potassium salt 在 溶剂黄146 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 生成 2-(4-fluorophenyl)-7-methyl-5-oxo-3,5-dihydroindolizine-6-carbonitrile
  参考文献：
  名称：

  Lin, Chyun-Feng; Lin, Yi-Feng; Lo, Yan-Chung, Heterocycles, 2000, vol. 53, # 1, p. 15 - 26

  摘要：

  DOI：

文献信息

• Antimicrobial Evaluation of New Synthesized Pyridine Nucleosides Under Solvent-Free Conditions
  作者：Nora M. Rateb、Hany A. El-Deab、Ibrahim M. Abdou

  DOI：10.1080/15257770.2013.827206

  日期：2013.9.2

  Two series of novel 3-cyano-2-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxo) pyridines and 3-cyano-2-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyloxy)-4-trifluromethyl-6-phenyl pyridine were synthesized using efficient microwave methods. The targeted compounds were obtained in high yields by reacting 2-(1H)-pyridone or its salt with activated sugars using SiO2 under solvent-free conditions. Ammonolysis of the resulted acetylated nucleosides produced 3-cyano-2-(b beta-D-glucopyranosyloxo)-pyridines and 3-cyano-2-(beta-D-ribofuranosyloxy)-4-trifluoromethyl-6-phenyl pyridine. These new products were fully characterized using 1D and 2D NMR. These compounds were screened for their antibacterial activities against G(+) and G(-) bacteria and some found to exhibit better antibacterial activities than the control drug.
• Gewald,K.; Jaensch,H.J., Journal fur praktische Chemie (Leipzig 1954), 1976, vol. 318, p. 313 - 320
  作者：Gewald,K.、Jaensch,H.J.

  DOI：——

  日期：——