4-Diethoxymethyl-<1H,6H>-6-pyrimidon | 98841-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Diethoxymethyl-<1H,6H>-6-pyrimidon
• 英文别名: 6-diethoxymethyl-3H-pyrimidin-4-one；6-Diaethoxymethyl-3H-pyrimidin-4-on；6-(Diethoxymethyl)pyrimidin-4-ol；4-(diethoxymethyl)-1H-pyrimidin-6-one
• CAS: 98841-44-2
• 化学式: C₉H₁₄N₂O₃
• 分子量: 198.222
• InChiKey: XMBUYMQJFXTNDR-UHFFFAOYSA-N

物化性质

• 熔点：
  123-124 °C
• 沸点：
  274.4±50.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  59.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-Diethoxymethyl-<1H,6H>-6-pyrimidon 在 盐酸 作用下， 生成 6-羟基-4-嘧啶甲酸
  参考文献：
  名称：

  Claesen; Vanderhaeghe, Bulletin des Societes Chimiques Belges, 1957, vol. 66, p. 292,298

  摘要：

  DOI：
• 作为产物：
  描述：

  6-diethoxymethyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 在 ammonium hydroxide 、 镍 作用下， 生成 4-Diethoxymethyl-<1H,6H>-6-pyrimidon
  参考文献：
  名称：

  Claesen; Vanderhaeghe, Bulletin des Societes Chimiques Belges, 1957, vol. 66, p. 292,298

  摘要：

  DOI：

文献信息

• NOVEL SUBSTITUTED PYRIMIDINYLOXY UREAS USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Lang Hengyuan

  公开号：US20070155764A1

  公开（公告）日：2007-07-05

  The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.

  本发明涉及化合物和方法，用作蛋白激酶的抑制剂，包括B-Raf以及几种受体酪氨酸激酶和细胞质酪氨酸激酶。本发明涉及新的取代嘧啶氧基脲化合物II、III和IV的配方及其作为药物治疗疾病的应用。还提供了在人类或动物主体中调节蛋白激酶活性的方法，用于治疗癌症等疾病。
• NOVEL SUBSTITUTED PYRIDINYLOXY AND PYRIMIDINYLOXY AMIDES USEFUL AS INHIBITORS OF PROTEIN KINASES
  申请人：Lang Hengyuan

  公开号：US20070155746A1

  公开（公告）日：2007-07-05

  The present invention relates to compounds and methods useful as inhibitors of protein kinases, including B-Raf and several receptor tyrosine and cytoplasmic tyrosine kinases. The present invention is directed to new substituted pyrimidinyloxy urea compounds of Formulas II, III and IV and compositions and their application as pharmaceuticals for the treatment of disease. Methods of modulating of protein kinase activity in a human or animal subject are also provided for the treatment diseases such as cancers.

  本发明涉及化合物和方法，用作蛋白激酶的抑制剂，包括B-Raf以及几种受体酪氨酸激酶和细胞质酪氨酸激酶。本发明涉及新的取代嘧啶基氧脲化合物II、III和IV的公式，以及这些化合物的组合物和它们作为治疗疾病的药物的应用。还提供了一种在人类或动物主体中调节蛋白激酶活性的方法，用于治疗癌症等疾病。
• Epoxy resin structural adhesive composition having high temperature resistance
  申请人：LORD CORPORATION

  公开号：EP0596622A2

  公开（公告）日：1994-05-11

  A structural adhesive composition containing an epoxy compound, an amine hardener and a hydroxy-substituted aromatic compound having a pKa ranging from about 5 to 9.7 and a boiling point greater than about 210°C. The utilization of a hydroxy-substituted aromatic compound having a pKa and a boiling point within the stated ranges provides for an adhesive composition which develops significant green strength, undergoes minimal sinkage during the bonding and curing process, and is capable of withstanding high temperature conditions.

  一种结构粘合剂组合物，含有环氧化合物、胺固化剂和羟基取代的芳香族化合物，其 pKa 在 5 至 9.7 之间，沸点高于 210°C。使用 pKa 和沸点均在上述范围内的羟基取代芳香族化合物制成的粘合剂组合物具有显著的生坯强度，在粘合和固化过程中下沉最小，并能承受高温条件。
• HETEROCYCLIC PHOSPHONIC ACIDS. II
  作者：ALFRED BURGER、JOHN B. CLEMENTS、NORMAN D. DAWSON、ROBERT B. HENDERSON

  DOI：10.1021/jo01127a015

  日期：1955.10
• US5385990A
  申请人：——

  公开号：US5385990A

  公开（公告）日：1995-01-31