3-benzyl-5,5-bis(4-bromophenyl)-imidazolidine-2,4-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 3-benzyl-5,5-bis(4-bromophenyl)-imidazolidine-2,4-dione
• 英文别名: 3-Benzyl-5,5-bis-(4-bromo-phenyl)-imidazolidine-2,4-dione；3-benzyl-5,5-bis(4-bromophenyl)imidazolidine-2,4-dione
• 化学式: C₂₂H₁₆Br₂N₂O₂
• 分子量: 500.189
• InChiKey: UASAQYLINUGGDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-双(4-溴苯基)-2-羟基乙酮 在 氢氧化钾 、 硝酸 作用下， 以 二甲基亚砜 为溶剂， 生成 3-benzyl-5,5-bis(4-bromophenyl)-imidazolidine-2,4-dione
  参考文献：
  名称：

  Versatile Access to Benzhydryl-Phenylureas through an Unexpected Rearrangement during Microwave-Enhanced Synthesis of Hydantoins

  摘要：

  A new access to benzhydryl-phenylureas is described. These new interesting urea derivatives were obtained by reaction of substituted benzils with substituted phenylureas under microwave irradiation. Phenylthiourea, when reacted with benzil, gave 3-phenyl-thiohydantoin. Moreover, benzylurea, as phenethylurea, gave the corresponding 3-substituted hydantoin derivatives, demonstrating that only phenylurea derivatives can result in benzhydryl-phenylureas under the applied conditions. This new reaction proved to be an easy access to substituted 1-benzhydryl-3-phenyl-ureas.

  DOI：

  10.1021/ol035282x