Fmoc-Tyr(OBut)-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Fmoc-Tyr(OBut)-OH
• 英文别名: tert-Butyl (((9H-fluoren-9-yl)methoxy)carbonyl)-D-tyrosinate；tert-butyl 2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(4-hydroxyphenyl)propanoate
• 化学式: C₂₈H₂₉NO₅
• 分子量: 459.542
• InChiKey: VJSGNJOUWWMJDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  34
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  84.9
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Fmoc-Tyr(OBut)-OH 、 异氰酸苄酯 在 N,N-二异丙基乙胺 、 Methanaminium,N-[(dimethylamino)(3H-1,2,3-triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methyl-, hexafluorophosphate(1-) 、 哌啶 、 甲酸 、 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N-甲基吡咯烷酮 、 DMF (N,N-dimethyl-formamide) 为溶剂， 反应 4.13h， 生成 2-methyl-6-(p-hydroxyphenylmethyl)-8-naphthyl-4,7-dioxo-hexahydro-pyrazino[2,1-c][1,2,4]triazine-1-carboxylic acid benzylamide
  参考文献：
  名称：

  [EN] REVERSE-TURN MIMETICS AND METHOD RELATING THERETO
  [FR] MIMETIQUES A ROTATION INVERSE ET PROCEDE ASSOCIE

  摘要：

  公开号：

  WO2005116032A3

文献信息

• MACROCYCLIC COMPOUNDS FOR INHIBITION OF INHIBITORS OF APOPTOSIS
  申请人：Ensemble Therapeutics Corp.

  公开号：US20140135270A1

  公开（公告）日：2014-05-15

  There are disclosed compounds that modulate the activity of inhibitors of apoptosis (IAPs), pharmaceutical compositions containing said compounds and methods of treating proliferative disorders and disorders of dysregulated apoptosis, such as cancer, utilizing the compounds of the invention.

  这里公开了调节凋亡抑制剂（IAPs）活性的化合物，包含所述化合物的药物组合物以及使用本发明的化合物治疗增殖性疾病和凋亡失调疾病的方法，例如癌症。
• Insertion of unnatural metal ligand in the heme pocket of nitrophorin through protein semi-synthesis: toward biomimicking binuclear active sites
  作者：Yonglu Chen、Yi Zhou、Chunmao He

  DOI：10.1016/j.cclet.2023.108251

  日期：2023.2

  protein segment via native chemical ligation. The semi-synthetic NP2 was able to accept the natural heme b cofactor and the Dpa ligand was able to bind Cu(II)/Fe(III) ions, leading to heteronuclear active site.

  在此，我们报告了一种半合成策略，提供硝基蛋白 2 (NP2) 变体，其中N,N'-双(2-吡啶甲基)胺 (Dpa) 配体作为选择性安装在位置 27 的侧链，由合成肽组装而成带有 Dpa 配体和通过天然化学连接表达的蛋白质片段的硫酯。半合成的 NP2 能够接受天然血红素b辅因子，Dpa 配体能够结合 Cu(II)/Fe(III) 离子，形成异核活性位点。
• THIADIAZOLE MODULATORS OF BETA ADRENERGIC RECEPTOR
  申请人：Rao Tadimeti

  公开号：US20110086847A1

  公开（公告）日：2011-04-14

  The present invention relates to new thiadiazole modulators of beta adrenergic receptor activity, pharmaceutical compositions thereof, and methods of use thereof.
• BETA-HAIRPIN PEPTIDOMIMETICS
  申请人：Barthélémy Sophie

  公开号：US20120283196A1

  公开（公告）日：2012-11-08

  β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa 1 -Xaa 2 -Xaa 3 -Xaa 4 -Xaa 5 -Xaa 6 -Xaa 7 -Xaa 8 -Xaa 9 -Xaa 10 -Xaa 11 -Xaa 12 -Xaa 13 -Xaa 14 -Xaa 15 -Xaa 16 -), and pharmaceutically acceptable salts thereof, with Xaa 1-Xaa 16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and prolonged half-lives in vivo and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections eases of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy.
• US6423689B1
  申请人：——

  公开号：US6423689B1

  公开（公告）日：2002-07-23