5H-[1,4]dithiepino[6,5-b]pyridine-8-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5H-[1,4]dithiepino[6,5-b]pyridine-8-carboxylic acid
• 化学式: C₉H₇NO₂S₂
• 分子量: 225.292
• InChiKey: WETGDDZUTXTONR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-hydroxymethyl-1,1,4,4-tetraoxide-1,4-Dithiepan-6-one 、 β-氨基巴豆酸甲酯 、 2-氟-3-(三氟甲基)苯甲醛 生成 5H-[1,4]dithiepino[6,5-b]pyridine-8-carboxylic acid
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Dithiepino [6,5-b]pyridines, and related compositions and methods
  申请人：——

  公开号：US20020026051A1

  公开（公告）日：2002-02-28

  This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. 1 These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

  本发明提供了以下公式的新型二噻吩[6,5-b]吡啶化合物。1这些化合物可用作具有心血管、抗哮喘和抗支气管痉挛活性的钙通道拮抗剂。因此，本发明还提供了用于预防和治疗过敏、过敏、哮喘、支气管痉挛、痛经、食管痉挛、青光眼、早产、泌尿道疾病、胃肠动力障碍和心血管疾病等疾病的药物组合物以及方法。
• Dithiepino[6,5-b]pyridines, and related compositions and methods
  申请人：——

  公开号：US20020032332A1

  公开（公告）日：2002-03-14

  This invention provides novel dithiepino[6,5-b]pyridines of the following formulae. 1 These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibronchoconstriction activity. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders.

  这项发明提供了以下式子的新型二硫杂二环[6,5-b]吡啶化合物。1这些化合物可作为钙通道拮抗剂，具有心血管、抗哮喘和抗支气管收缩活性。因此，这项发明还提供了预防和治疗过敏、过敏、哮喘、支气管痉挛、痛经、食管痉挛、青光眼、早产、泌尿道疾病、胃肠动力障碍和心血管疾病等疾病的药物组合物和方法。
• Dihydropyridine soft drugs, and related compositions and methods
  申请人：——

  公开号：US20030225120A1

  公开（公告）日：2003-12-04

  This invention relates to novel dihydropyridine soft drugs of the formula &PHgr;OOR 1 , where &PHgr; is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.

  本发明涉及一种新型二氢吡啶软药物，其化学式为&PHgr;OOR1，其中&PHgr;是二氢吡啶基团。这些化合物可用作钙通道拮抗剂，具有心血管、抗哮喘和抗支气管收缩活性。使用这样的软药物类似物允许以更大的剂量给予所述二氢吡啶化合物，而不会出现不可耐受的全身性影响。因此，本发明还提供了用于预防和治疗过敏、哮喘、支气管痉挛、痛经、食管痉挛、青光眼、早产、泌尿道疾病、胃肠运动障碍和心血管疾病等疾病的药物组合物，以及避免不必要的全身性影响的方法。
• DITHIEPINO 6,5-b]PYRIDINES, AND RELATED COMPOSITIONS AND METHODS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1192163A1

  公开（公告）日：2002-04-03
• DIHYDROPYRIDINE COMPOUNDS FOR THE INHIBITION OF CALCIUM-INFLUX
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1296990A2

  公开（公告）日：2003-04-02