(3-methyl-4-nitrophenoxy)-acetic acid t-butyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3-methyl-4-nitrophenoxy)-acetic acid t-butyl ester
• 英文别名: t-butyl 3-methyl-4-nitrophenoxyacetate；tert-butyl 2-(3-methyl-4-nitrophenoxy)acetate
• 化学式: C₁₃H₁₇NO₅
• 分子量: 267.282
• InChiKey: JFYGUFVMKZRBCB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  81.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3-methyl-4-nitrophenoxy)-acetic acid t-butyl ester 在 钯 作用下， 以 乙醇 为溶剂， 反应 18.0h， 以to give (4-amino-3-methylphenoxy)-acetic acid t-butyl ester as an oil的产率得到(4-amino-3-methylphenoxy)-acetic acid t-butyl ester
  参考文献：
  名称：

  Cyclic sulfamide derivatives and methods of use

  摘要：

  公式1的化合物可提供药理学制剂，这些制剂是PTP酶的抑制剂，特别是公式I的化合物抑制PTP-1B和TC PTP，因此可用于治疗与PTP酶活性相关的疾病。本发明的化合物也可用于抑制其他具有磷酸酪氨酸结合区域（如SH2结构域）的酶。因此，公式I的化合物可用于预防或治疗与肥胖、葡萄糖不耐受、糖尿病、高血压和大、小血管缺血性疾病相关的胰岛素抵抗。本发明的化合物还可用于治疗、预防或控制伴随2型糖尿病的许多疾病，包括高脂血症、高三酰甘油血症、动脉粥样硬化、血管再狭窄、肠易激综合征、胰腺炎、脂肪细胞肿瘤和脂肪肉瘤、脂质代谢异常以及其他表现为胰岛素抵抗的疾病。此外，本发明的化合物还可用于治疗或预防癌症、骨质疏松症、神经退行性和传染性疾病以及涉及炎症和免疫系统的疾病。

  公开号：

  US20040023974A1
• 作为产物：
  描述：

  溴乙酸叔丁酯 、 4-硝基间甲苯酚 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 生成 (3-methyl-4-nitrophenoxy)-acetic acid t-butyl ester
  参考文献：
  名称：

  Acylurea derivatives

  摘要：

  本发明涉及化学式I的化合物，其中R.sup.1 -CON（R.sup.2）-CON（R.sup.3）-X.sup.1-Q-X.sup.2-GI及其药学上可接受的代谢不稳定酯或酰胺，以及其药学上可接受的盐，其中R.sup.1，R.sup.2，R.sup.3，X.sup.1，Q，X.sup.2和G具有规范中给定的含义。本发明涉及制备化学式I的化合物的方法，含有它们的制药组合物以及它们作为纤维蛋白原与糖蛋白IIb / IIIa结合抑制剂的用途。

  公开号：

  US05576334A1

文献信息

• Acylurea derivatives
  申请人：Zeneca Limited

  公开号：US05576334A1

  公开（公告）日：1996-11-19

  The invention concerns chemical compounds of formula I R.sup.1 --CON(R.sup.2)--CON(R.sup.3)--X.sup.1 --Q--X.sup.2 --GI and pharmaceutically acceptable metabolically labile esters or amides thereof, and pharmaceutically acceptable salts thereof, in which R.sup.1, R.sup.2, R.sup.3, X.sup.1, Q, X.sup.2 and G have the meanings given in the specification. The invention concerns processes for the preparation of the chemical compounds of formula I, pharmaceutical compositions containing them and their use as inhibitors of the binding of fibrinogen to glycoprotein IIb/IIIa.

  本发明涉及化学式I的化合物，其中R.sup.1 -CON（R.sup.2）-CON（R.sup.3）-X.sup.1-Q-X.sup.2-GI及其药学上可接受的代谢不稳定酯或酰胺，以及其药学上可接受的盐，其中R.sup.1，R.sup.2，R.sup.3，X.sup.1，Q，X.sup.2和G具有规范中给定的含义。本发明涉及制备化学式I的化合物的方法，含有它们的制药组合物以及它们作为纤维蛋白原与糖蛋白IIb / IIIa结合抑制剂的用途。
• 5-Substituted 1,1-dioxo-'1,2,5!thiazolidine-3-one derivatives as ptpase 1b inhibitors
  申请人：Coppola Mark Gary

  公开号：US20050090502A1

  公开（公告）日：2005-04-28

  Compounds of the formula provide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditions associated with PTPase activity. The compounds of the present invention may also be employed for inhibition of other enzymes with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula I may be employed for prevention or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels. The compounds of the present invention may also be employed in the treatment, prevention or control of a number of conditions that accompany Type 2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat or prevent cancer, osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

  公式I的化合物提供了药理剂，这些药理剂是PTP酶的抑制剂，特别是公式I的化合物可以抑制PTP-1B和TC PTP，因此可用于治疗与PTP酶活性相关的疾病。本发明的化合物还可用于抑制具有磷酸酪氨酸结合区域的其他酶，例如SH2结构域。因此，公式I的化合物可用于预防或治疗与肥胖、葡萄糖不耐受、糖尿病、高血压以及大、小血管缺血性疾病相关的胰岛素抵抗症状。本发明的化合物还可用于治疗、预防或控制伴随2型糖尿病的多种疾病，包括高脂血症、高三酰甘油血症、动脉粥样硬化、血管再狭窄、肠易激综合征、胰腺炎、脂肪细胞肿瘤和脂肪肉瘤、脂质代谢紊乱以及其他表现为胰岛素抵抗的疾病。此外，本发明的化合物还可用于治疗或预防癌症、骨质疏松症、神经退行性和传染性疾病以及涉及炎症和免疫系统的疾病。
• Cyclic sulfamide derivatives and methods of use
  申请人：——

  公开号：US20040023974A1

  公开（公告）日：2004-02-05

  Compounds of the formula 1 provide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditions associated with PTPase activity. The compounds of the present invention may also be employed for inhibition of other enzymes with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula I may be employed for prevention or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels. The compounds of the present invention may also be employed in the treatment, prevention or control of a number of conditions that accompany Type 2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat or prevent cancer, osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

  公式1的化合物可提供药理学制剂，这些制剂是PTP酶的抑制剂，特别是公式I的化合物抑制PTP-1B和TC PTP，因此可用于治疗与PTP酶活性相关的疾病。本发明的化合物也可用于抑制其他具有磷酸酪氨酸结合区域（如SH2结构域）的酶。因此，公式I的化合物可用于预防或治疗与肥胖、葡萄糖不耐受、糖尿病、高血压和大、小血管缺血性疾病相关的胰岛素抵抗。本发明的化合物还可用于治疗、预防或控制伴随2型糖尿病的许多疾病，包括高脂血症、高三酰甘油血症、动脉粥样硬化、血管再狭窄、肠易激综合征、胰腺炎、脂肪细胞肿瘤和脂肪肉瘤、脂质代谢异常以及其他表现为胰岛素抵抗的疾病。此外，本发明的化合物还可用于治疗或预防癌症、骨质疏松症、神经退行性和传染性疾病以及涉及炎症和免疫系统的疾病。
• 5-substituted 1,1-dioxo-1,2,5,-thiadiazolidin-3-one derivatives
  申请人：Novartis AG

  公开号：US07291635B2

  公开（公告）日：2007-11-06

  Compounds of the formula provide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditions associated with PTPase activity. The compounds of the present invention may also be employed for inhibition of other enzymes with a phosphotyrosine binding region such as the SH2 domain. Accordingly, the compounds of formula I may be employed for prevention or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels. The compounds of the present invention may also be employed in the treatment, prevention or control of a number of conditions that accompany Type 2 diabetes, including hyperlipidemia, hypertriglyceridemia, atherosclerosis, vascular restenosis, irritable bowel syndrome, pancreatitis, adipose cell tumors and carcinomas such as liposarcoma, dyslipidemia, and other disorders where insulin resistance is indicated. In addition, the compounds of the present invention may be employed to treat or prevent cancer, osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

  公式I的化合物提供了一种PTP酶抑制剂的药理药物，特别是公式I的化合物抑制PTP-1B和TC PTP，因此可以用于治疗与PTP酶活性相关的疾病。本发明的化合物也可以用于抑制其他具有磷酸酪氨酸结合区域的酶，如SH2结构域。因此，公式I的化合物可以用于预防或治疗与肥胖、葡萄糖不耐受、糖尿病、高血压和大、小血管缺血性疾病相关的胰岛素抵抗症状。本发明的化合物还可用于治疗、预防或控制伴随2型糖尿病的多种疾病，包括高血脂症、高三酰甘油血症、动脉粥样硬化、血管再狭窄、肠易激综合征、胰腺炎、脂肪细胞肿瘤和脂肪肉瘤、脂质代谢紊乱以及其他胰岛素抵抗症状的疾病。此外，本发明的化合物还可用于治疗或预防癌症、骨质疏松症、神经退行性和传染性疾病，以及涉及炎症和免疫系统的疾病。
• 5-substituted 1,1-dioxo-[1,2,5]thiazolidine-3-one derivatives as PTPASE 1B inhibitors
  申请人：Novartis AG

  公开号：EP2341049A1

  公开（公告）日：2011-07-06

  Compounds of the formula wherein L1, L2, L3, Q1, Q2, R1, R2, X, Y and Z are as decribed in the description fo the invention, provide pharmacological agents which are inhibitors of PTPases, in particular, the compounds of formula I inhibit PTP-1B and TC PTP, and thus may be employed for the treatment of conditions associated with PTPase activity. Accordingly, the compounds of formula I may be employed for prevention or treatment of insulin resistance associated with obesity, glucose intolerance, diabetes mellitus, hypertension and ischemic diseases of the large and small blood vessels. In addition, the compounds of the present invention may be employed to treat or prevent cancer, osteoporosis, neurodegenerative and infectious diseases, and diseases involving inflammation and the immune system.

  式中的化合物 其中 L1、L2、L3、Q1、Q2、R1、R2、X、Y 和 Z 如本发明所述，提供了作为 PTP 酶抑制剂的药剂，特别是式 I 化合物抑制 PTP-1B 和 TC PTP，因此可用于治疗与 PTP 酶活性相关的疾病。因此，式 I 化合物可用于预防或治疗与肥胖、葡萄糖不耐受、糖尿病、高血压和大血管及小血管缺血性疾病相关的胰岛素抵抗。此外，本发明的化合物还可用于治疗或预防癌症、骨质疏松症、神经退行性疾病和传染性疾病，以及涉及炎症和免疫系统的疾病。