4-(4-ethenylbenzyloxy)butan-1-ol | 92035-97-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-ethenylbenzyloxy)butan-1-ol
• 英文别名: (4-Vinyl-benzyl)-(2-hydroxy-butyl)-ether；4-[(4-Ethenylphenyl)methoxy]butan-1-OL
• CAS: 92035-97-7
• 化学式: C₁₃H₁₈O₂
• 分子量: 206.285
• InChiKey: ZCVDFTDKYCFDBG-UHFFFAOYSA-N

物化性质

• 沸点：
  324.2±30.0 °C(Predicted)
• 密度：
  1.023±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-ethenylbenzyloxy)butan-1-ol 在 4-二甲氨基吡啶 、 氢氧化钾 、 草酰氯 、 sodium hydride 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 59.0h， 生成 2-[4-[(4-Ethenylphenyl)methoxy]butyl]-2-methylpropanedioyl dichloride
  参考文献：
  名称：

  Insoluble polystyrene-bound bis(oxazoline): batch and continuous-flow heterogeneous enantioselective glyoxylate–ene reaction

  摘要：

  The use of a new, insoluble polymer-bound bis(oxazoline) ligand (IPB-box) for the copper-catalyzed heterogeneous enantioselective glyoxylate-ene reaction is described. Good activity and ee values in the range 85-95% have been obtained during five to seven recycles, either in batch mode or under flow conditions, demonstrating also the recovery and reuse of the whole catalytically active copper complex. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2004.08.015
• 作为产物：
  描述：

  1-({4-[(tert-butyl)dimethylsilyloxy]butoxy}methyl)-4-ethenylbenzene 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以97%的产率得到4-(4-ethenylbenzyloxy)butan-1-ol
  参考文献：
  名称：

  树枝状嵌入 TADDOL 聚苯乙烯珠粒的制备及其在对映选择性路易斯酸催化中的应用

  摘要：

  对 TADDOLates 的制备和使用进行了完整的说明，TADDOLates 以树枝状掺入聚苯乙烯珠粒中（方案 1）。已经制备了一系列苯乙烯基取代的 TADDOL，在 TADDOL 核心和苯乙烯基（数量为 2-16）之间具有柔性、刚性或树枝状支化间隔物（方案 2-4 中的 5-7、20、21、26 和图 1-3)。这些被用作苯乙烯悬浮聚合中的交联剂，导致约珠。400-μm 直径（方案 5 和 6，b）。这些依次负载钛酸盐并用于路易斯酸催化将 Et2Zn 添加到 PhCHO 作为测试反应（方案 6）。在标准条件下获得的对映选择性和转化度（均高达 99%）的比较，表明这些掺入聚合物的 Ti-TADDOLates 是该过程的高效催化剂（表 1）。鉴于制备新型固定化催化剂所需的努力，重点放在了它们的多种用途上。从 TADDOL 获得的聚合物在 20 次测试反应循环中的性能最好，该聚合物带有四个第一代

  DOI：

  10.1002/1522-2675(200201)85:1<352::aid-hlca352>3.0.co;2-d

文献信息

• Efficient Biocatalytic Cleavage and Recovery of Organic Substrates Supported on Soluble Polymers
  作者：Dario Pasini、Marco Filippini、Ilaria Pianetti、Massimo Pregnolato

  DOI：10.1002/adsc.200600376

  日期：2007.4.2

  solution-phase supports in combination with enzymes for biocatalytic transformations is reported. Ex novo designed styrene-based copolymers, bearing a phenylacetic residue in variable loadings and linked as a pendant group to the macromolecular backbone, through a spacer of variable length, have been synthesized and characterized. These derivatives are compatible and can be used as soluble supports in combination

  报道了新型溶液相载体与酶结合用于生物催化转化的适用性。从头设计的苯乙烯基共聚物已经合成并表征，该共聚物带有可变负载的苯乙酸残基，并通过侧链可变长度的间隔基作为侧基连接到大分子骨架上。这些衍生物具有相容性，可以与固定的青霉素G酰基转移酶（PGA – EC 3.5.1.11）结合用作可溶性载体，以定量产率在水或水/二甲基甲酰胺溶剂混合物中对共价锚定的有机底物进行生物催化裂解。回收固定化酶，活性损失可忽略不计。
• Polymer treatments
  申请人：Biocompatibles Limited

  公开号：US05453467A1

  公开（公告）日：1995-09-26

  A graft polymer obtainable by grafting a polymer substrate with a compound of formula (I), in which the groups R are the same or different and each is a straight or branched C.sub.1 -C.sub.4 alkyl group; X is an aryl group or a straight or branched C.sub.1 -C.sub.20 alkylene group, optionally containing one or more carbon-carbon double or triple bonds, ether linkages or aryl groups; the aryl groups being unsubstituted or substituted by one or more C.sub.1-4 alkyl groups; n is from 2 to 4; and A is a reactive group, is useful as a biocompatible material in contact lenses, biomedical devices and blood-containing devices. In a preferred embodiment A is a polymerizable group and the graft polymer is produced by radical initiated polymerization of the compound of formula (I) on the substrate which is initiated by a radical-forming group on the substrate.

  一种嫁接聚合物可通过将式(I)化合物与聚合物基质嫁接而得到，其中R基团相同或不同，每个基团均为直链或支链的C.sub.1-C.sub.4烷基；X为芳基或直链或支链的C.sub.1-C.sub.20亚烷基，可选含有一个或多个碳-碳双键或三键，醚键或芳基；芳基为未取代或被一个或多个C.sub.1-4烷基取代；n为2至4；A为反应性基团，可用作与隐形眼镜、生物医疗器械和含血液装置的生物相容材料。在首选实施例中，A为可聚合基团，通过基质上的自由基形成基引发的式(I)化合物的自由基引发聚合制备嫁接聚合物。
• Polymeric surface coatings
  申请人：Biocompatibles Limited

  公开号：US05648442A1

  公开（公告）日：1997-07-15

  Polymers of one or more radical polymerizable monomers which polymer has pendant groups bearing a center of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment of surfaces to render them biocompatible. The polymers may contain pendant groups which bind the polymer to a surface by physisorption, covalent bonding or ionic interactions. Additionally reactive groups in the polymer may serve as points for attachment of ligands to the polymer when coated on a surface.

  具有永久正电荷中心的挂基团和能够稳定地将聚合物结合在表面上的其他挂基团的单体的聚合物是表面处理中用于使其生物相容的有用材料。聚合物可以包含通过物理吸附、共价键合或离子相互作用将聚合物结合到表面的挂基团。此外，聚合物中的反应基团可以作为涂覆在表面上时配体附着的点。
• Polymeric blends with zwitterionic groups
  申请人：Biocompatibles Limited

  公开号：US05712326A1

  公开（公告）日：1998-01-27

  The biocompatibility of various polymers is improved by blending with them a polymer including a zwitterionic group. The zwitterionic group is usually an ammonium phosphate ester zwitterionic group and the polymer containing it may be produced by the free radical polymerisation of ethylenically unsaturated monomers including a monomer bearing the zwitterionic group. Blending of the two polymers may be achieved by dry blending particulate polymers or by mixing the polymers in liquid dispersion or solution followed by removal of the liquid medium. The fibrinogen absorption and/or platelet activation of polymers may be reduced to a value of less than 80% or even less than 60% of the base polymer by introducing amounts of more than 10% or mare than 30% of the zwitterionic group containing polymer. Preferred blends are of copolymers of 2-(methacryloyloxyethyl)-2'-(trimethylammonium)ethyl phosphate inner salt with higher alkyl (meth) acrylate, blended with olefin polymers and/or with rubber latices. The products may be used in medical devices in which they come into contact with bodily fluids, especially blood, plasma, serum and/or tear film.

  通过与含有一个双离子基团的聚合物混合，可以提高各种聚合物的生物相容性。双离子基团通常是一种酸酐磷酸酯双离子基团，含有该基团的聚合物可以通过自由基聚合乙烯基不饱和单体（包括含有该双离子基团的单体）制得。两种聚合物的混合可以通过干混颗粒聚合物或在液体分散或溶液中混合聚合物，然后去除液体介质来实现。通过引入超过10％或超过30％双离子基团含量的聚合物，可以将聚合物的纤维蛋白原吸收和/或血小板活化降低到低于基础聚合物的80％甚至低于60％的值。首选混合物是2-（甲基丙烯酰氧乙基）-2'-(三甲基铵）乙基磷酸内盐与较高烷基（甲基）丙烯酸酯的共聚物，与烯烃聚合物和/或橡胶乳液混合。产品可用于与体液（尤其是血液、血浆、血清和/或泪液）接触的医疗器械中。
• Biocompatible zwitterion polymers
  申请人：Biocompatibles Limited

  公开号：US05739236A1

  公开（公告）日：1998-04-14

  Polymers of one or more radical polymerisable monomers which polymer has pendant groups bearing a center of permanent positive charge and other pendant groups capable of stably binding the polymer to a surface are useful in the treatment of surfaces to render them biocompatible. The polymers may contain pendant groups which bind the polymer to a surface by physisorption, covalent bonding or ionic interactions. Additionally reactive groups in the polymer may serve as points for attachment of ligands to the polymer when coated on a surface.

  一种或多种自由基聚合单体聚合物的聚合物，其具有带有永久正电荷的侧基和能够稳定结合聚合物于表面的其他侧基，可用于处理表面以使其生物相容性。这些聚合物可以包含通过物理吸附、共价键合或离子相互作用将聚合物结合到表面的侧基。此外，聚合物中的反应性基团可以作为涂覆在表面上时配体附着的点。