2-[2'-benzyloxy-5'-(2"-benzyloxybenzyl)benzyl]-5-methoxyresorcinol | 1254569-81-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 2-[2'-benzyloxy-5'-(2"-benzyloxybenzyl)benzyl]-5-methoxyresorcinol
• 英文别名: 5-Methoxy-2-[[2-phenylmethoxy-5-[(2-phenylmethoxyphenyl)methyl]phenyl]methyl]benzene-1,3-diol
• CAS: 1254569-81-7
• 化学式: C₃₅H₃₂O₅
• 分子量: 532.636
• InChiKey: VSZAGTGOVAMYKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  68.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2'-benzyloxy-5'-(2"-benzyloxybenzyl)benzyl]-5-methoxyresorcinol 、 3-苯丙酰氯 以 氯仿 为溶剂， 反应 72.0h， 生成 1-[2,4-Dihydroxy-6-methoxy-3-[[2-phenylmethoxy-5-[(2-phenylmethoxyphenyl)methyl]phenyl]methyl]phenyl]-3-phenylpropan-1-one
  参考文献：
  名称：

  The first total synthesis of the natural product angoluvarin

  摘要：

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.037
• 作为产物：
  描述：

  夫拉美诺 、 2-benzyloxy-5-(2'-benzyloxybenzyl)benzyl alcohol 在 zinc(II) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 20.0h， 以34%的产率得到2-[2'-benzyloxy-5'-(2"-benzyloxybenzyl)benzyl]-5-methoxyresorcinol
  参考文献：
  名称：

  The first total synthesis of the natural product angoluvarin

  摘要：

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.08.037

文献信息

• The first total synthesis of the natural product angoluvarin
  作者：Charles F. Nutaitis

  DOI：10.1016/j.tetlet.2010.08.037

  日期：2010.10

  The total synthesis of angoluvarin, a member of the dihydrochalcone family of natural products, is reported. Starting with 2-bromophenol, the synthesis was accomplished in eight steps with an overall yield of 2%. This represents the first reported synthesis of angoluvarin. (C) 2010 Elsevier Ltd. All rights reserved.