8,8-dimethylnonanoic acid | 93843-15-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8,8-dimethylnonanoic acid
• 英文别名: 8,8-dimethyl-nonanoic acid；8,8-Dimethyl-nonansaeure；8,8-Dimethyl-pelargonsaeure；Neoundecanoic acid
• CAS: 93843-15-3
• 化学式: C₁₁H₂₂O₂
• 分子量: 186.294
• InChiKey: PCVAKFVNCSPYNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.91
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  8,8-dimethyl-4,7-dioxo-nonanoic acid 在 硫酸 作用下， 生成 8,8-dimethylnonanoic acid
  参考文献：
  名称：

  Lukes; Srogl, Collection of Czechoslovak Chemical Communications, 1959, vol. 24, p. 220,221,223

  摘要：

  DOI：

文献信息

• [EN] METHODS OF TREATING ALZHEIMER'S DISEASE USING AROMATICALLY SUBSTITUTED omega-AMINO-ALKANOIC ACID AMIDES AND ALKANOIC ACID DIAMIDES<br/>[FR] METHODES DE TRAITEMENT DE LA MALADIE D'ALZHEIMER AU MOYEN D'AMIDES D'ACIDE O-AMINO-ALCANOIQUE A SUBSTITUTIONS AROMATIQUES ET DE DIAMIDES D'ACIDE ALCANOIQUE
  申请人：ELAN PHARM INC

  公开号：WO2003103652A1

  公开（公告）日：2003-12-18

  Disclosed.are methods for treating Alzheimer's disease, and other diseases, and/or inhibiting beta-secretase enzyme, and/or inhibiting deposition of A beta peptide in a mammal, by use of compounds of formula (I) wherein the variables R1, R2, R3, R4, R5, X1, and X2 are defined herein.

  披露了治疗阿尔茨海默病和其他疾病，和/或抑制β-分泌酶酶，和/或通过使用式(I)化合物在哺乳动物体内抑制Aβ肽沉积的方法，其中变量R1、R2、R3、R4、R5、X1和X2在此处定义。
• NickelButadiene Catalytic System for the Cross-Coupling of Bromoalkanoic Acids with Alkyl Grignard Reagents: A Practical and Versatile Method for Preparing Fatty Acids
  作者：Takanori Iwasaki、Kiyokazu Higashikawa、Vutukuri P. Reddy、Willbe W. S. Ho、Yukari Fujimoto、Koichi Fukase、Jun Terao、Hitoshi Kuniyasu、Nobuaki Kambe

  DOI：10.1002/chem.201204222

  日期：2013.2.25

  The knights who say Ni: A practical and convenient synthetic route to fatty acids involves the Ni‐catalyzed alkylalkyl cross‐coupling of bromoalkanoic acids and alkyl Grignard reagents in the presence of 1,3‐butadiene as an additive (see scheme).

  说Ni的骑士们：一种实用且方便的合成脂肪酸途径涉及在1,3-丁二烯作为添加剂的情况下，Ni催化的溴链烷酸与烷基Grignard试剂的烷基烷基交叉偶联（参见方案）。
• Pyrimidine nucleoside derivatives having anti-tumor activity, their preparation and use
  申请人：Sankyo Company Limited

  公开号：EP0536936A1

  公开（公告）日：1993-04-14

  Compounds of formula (I): [in which: R¹, R² and R³ are the same or different and each represents a hydrogen atom, an optionally substituted alkanoyl group or an alkenylcarbonyl group, provided that at least one of R¹, R² and R³ represents an unsubstituted alkanoyl group having from 5 to 24 carbon atoms, said substituted alkanoyl group or said alkenylcarbonyl group; and one of R⁴ and R⁵ represents a hydrogen atom and the other represents a cyano group]; have valuable anti-tumour activity.

  式子（I）的化合物：[其中：R¹、R²和R³相同或不同，每个代表氢原子、可选取代的脂肪酰基团或烯基羰基团，前提是至少有一个R¹、R²和R³代表有5到24个碳原子的未取代脂肪酰基团，或者是所述取代的脂肪酰基团或所述烯基羰基团；R⁴和R⁵中的一个代表氢原子，另一个代表氰基]，具有有价值的抗肿瘤活性。
• Amino acids with affinity for the alpha2delta-protein
  申请人：Barta Nancy Sue

  公开号：US20050272783A1

  公开（公告）日：2005-12-08

  This invention relates to certain β-amino acids that bind to the alpha-2-delta (α2δ) subunit of a calcium channel. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric pain and other disorders.

  本发明涉及一些能够与钙通道的α2δ亚单位结合的β-氨基酸。这些化合物及其药学上可接受的盐在治疗各种精神疼痛和其他疾病方面非常有用。
• Personal care products incorporating cellulosic fatty acid esters
  申请人：Shelton Charles Michael

  公开号：US20070053855A1

  公开（公告）日：2007-03-08

  Cellulose ester compounds and compositions that include such cellulose ester compounds dissolved in lipophilic solvents.

  纤维素酯化合物及包括这种纤维素酯化合物在亲脂溶剂中溶解的组合物。