tris(3,4-dimethylphenyl)phosphite | 63351-00-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris(3,4-dimethylphenyl)phosphite
• 英文别名: Phenol, 3,4-dimethyl-, phosphite (3:1)；tris(3,4-dimethylphenyl) phosphite
• CAS: 63351-00-8
• 化学式: C₂₄H₂₇O₃P
• 分子量: 394.45
• InChiKey: TZDXHGSMUMMGNF-UHFFFAOYSA-N

物化性质

• 沸点：
  473.6±45.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  tris(3,4-dimethylphenyl)phosphite 在 氢溴酸 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 溶剂黄146 、 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Human Neutrophil Elastase Phosphonic Inhibitors with Improved Potency of Action

  摘要：

  Herein, we present the synthesis and the measurement of the inhibitory activity of novel peptidyl derivatives of alpha-aminoalkylphosphonate diaryl esters as human neutrophil elastase inhibitors. Their selectivity against other serine proteases, including porcine pancreatic elastase, chymotrypsin, and trypsin, was also demonstrated. We also describe the preparation of single peptide diastereomers. The most active and selective compound developed possessed a k(inact)/K-1 of 2353000 M-1 s(-1), which is the most potent irreversible peptidyl inhibitor of human neutrophil elastase reported to date. The peptidyl inhibitors were demonstrated to be stable in PBS buffer and human plasma, as were their complexes with HNE.

  DOI：

  10.1021/jm300599x
• 作为产物：
  描述：

  3,4-二甲基苯酚 在 三氯化磷 作用下， 以 乙腈 为溶剂， 反应 4.0h， 生成 tris(3,4-dimethylphenyl)phosphite
  参考文献：
  名称：

  α-氨基芳烷基膦酸的新型芳香单酯作为氨基肽酶N / CD13的抑制剂

  摘要：

  通过选择性水解相应的α-氨基芳烷基膦酸芳族二酯，合成了一系列新的α-氨基芳烷基膦酸芳族单酯。开发了新的潜在的氨基肽酶N / CD13抑制剂，这是一种在肿瘤血管生成中很重要的酶。高苯丙氨酸和正亮氨酸相关的单芳基膦酸酯的一些衍生物显示出比相应的α-氨基芳烷基膦酸对氨基肽酶N / CD13更高的抑制能力。单独或与TNF-α一起检测了一种新抑制剂对人PANC-1和HT-1080细胞系生长的影响。

  DOI：

  10.1016/j.bmc.2010.02.056

文献信息

• Simple phosphonic inhibitors of human neutrophil elastase
  作者：Marcin Sieńczyk、Łukasz Winiarski、Paulina Kasperkiewicz、Mateusz Psurski、Joanna Wietrzyk、Józef Oleksyszyn

  DOI：10.1016/j.bmcl.2011.01.083

  日期：2011.3

  Herein, we describe the synthesis and resulting activity of a complex series of alpha-aminophosphonate diaryl esters as irreversible human neutrophil elastase inhibitors and their selectivity preference for human neutrophil elastase over several other serine proteases such as porcine pancreatic elastase, trypsin, and chymotrypsin. We synthesized and examined the inhibitory potency of several new simple Cbz-protected alpha-aminoalkylphosphonate diaryl esters that yielded several new HNE inhibitors, where one of the obtained compounds Cbz-Val(P)(OC6H4-4-COOMe)(2) displayed an apparent second-order inhibition value at 33,015 M (1) s (1). (C) 2011 Elsevier Ltd. All rights reserved.
• US4067903A
  申请人：——

  公开号：US4067903A

  公开（公告）日：1978-01-10