(1R,10S)-Tricyclo[8.2.1.0^3,8]trideca-3,5,7-trien-13-amine | 77954-86-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: (1R,10S)-Tricyclo[8.2.1.0^3,8]trideca-3,5,7-trien-13-amine
• 英文别名: 11-endo-amino-5,6,7,8,9,10-hexahydro-6,9-methanobenzocycloocten
• CAS: 77954-86-0
• 化学式: C₁₃H₁₇N
• 分子量: 187.285
• InChiKey: YCLLIDPFIZIHBB-ITGUQSILSA-N

物化性质

• 沸点：
  307.6±31.0 °C(Predicted)
• 密度：
  1.051±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.14
• 重原子数：
  14.0
• 可旋转键数：
  0.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  26.02
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (1R,10S)-Tricyclo[8.2.1.0^3,8]trideca-3,5,7-trien-13-amine 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 生成
  参考文献：
  名称：

  Cyclic sulfamide γ-secretase inhibitors

  摘要：

  A novel series of N-alkyl-substituted cyclic sulfamides were developed from a screening hit. Chemistries were developed which allowed surveys of N-alkyl groups and amines resulting in the identification of N-trifluoroethyl-substituted cyclic sulfamides with good in vitro and in vivo gamma-secretase activity. One compound with subnanomolar activity elicited a reduction in brain A beta 40 after oral dosing in APP-YAC mice. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.06.084
• 作为产物：
  描述：

  三环[8.2.1.03,8]十三-3,5,7-三烯-13-酮 在 platinum(IV) oxide 吡啶 、 盐酸羟胺 、 氢气 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 反应 2.75h， 生成 (1R,10S)-Tricyclo[8.2.1.0^3,8]trideca-3,5,7-trien-13-amine
  参考文献：
  名称：

  Synthesis and stereochemistry of 11-substituted 5,6,7,8,9,10-hexahydro-6,9-methanobenzocyclooctenes

  摘要：

  DOI：

  10.1021/jo00143a032

文献信息

• METHODS FOR TREATING OR PREVENTING CANCER AND NEURODEGENERATIVE DISEASES
  申请人：Zhu Lei

  公开号：US20130158017A1

  公开（公告）日：2013-06-20

  Provided are methods of treating or preventing a neurodegenerative disease comprising administering to a subject having a neurodegenerative disease an effective amount of a compound of Formula I: where X, R 1 , R 2 , subscript m, subscript n and subscript v are as defined herein.

  提供了一种治疗或预防神经退行性疾病的方法，包括向患有神经退行性疾病的受试者施用公式I的化合物的有效量，其中X，R1，R2，下标m，下标n和下标v如此处所定义。
• A novel series of potent γ-secretase inhibitors based on a benzobicyclo[4.2.1]nonane core
  作者：Stephen J. Lewis、Adrian L. Smith、Joseph G. Neduvelil、Graeme I. Stevenson、Matthew J. Lindon、A. Brian Jones、Mark S. Shearman、Dirk Beher、Earl Clarke、Jonathan D. Best、James E. Peachey、Timothy Harrison、J. Luis Castro

  DOI：10.1016/j.bmcl.2004.10.062

  日期：2005.1

  A new series of gamma-secretase inhibitors was developed from an in-house screening hit based on a benzobicyclo[4.2.1]nonane core. Lead optimisation studies led to the development of a series of potent inhibitors and in vivo efficacy was demonstrated. (C) 2004 Elsevier Ltd. All rights reserved.
• BELANGER, P. C.;YOUNG, R. N.;SCHEIGETZ, J.;DUFRESNE, C.;SPRINGER, J. P., J. ORG. CHEM., 1982, 47, N 22, 4329-4334
  作者：BELANGER, P. C.、YOUNG, R. N.、SCHEIGETZ, J.、DUFRESNE, C.、SPRINGER, J. P.

  DOI：——

  日期：——
• US9056857B2
  申请人：——

  公开号：US9056857B2

  公开（公告）日：2015-06-16