tert-butyl N-[2-[(7-methyl-1,8-naphthyridin-2-yl)amino]-2-oxoethyl]carbamate | 244298-11-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tert-butyl N-[2-[(7-methyl-1,8-naphthyridin-2-yl)amino]-2-oxoethyl]carbamate
• CAS: 244298-11-1
• 化学式: C₁₆H₂₀N₄O₃
• 分子量: 316.36
• InChiKey: HFKFAWLKFLGKCO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl N-[2-[(7-methyl-1,8-naphthyridin-2-yl)amino]-2-oxoethyl]carbamate 在 盐酸 作用下， 以 氯仿 、 乙酸乙酯 为溶剂， 以100%的产率得到2-(2-aminoacetyl)amino-7-methyl-1,8-naphthyridine
  参考文献：
  名称：

  Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA

  摘要：

  DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one-electron oxidation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01189-2
• 作为产物：
  描述：

  2,6-二氨基吡啶 以 氯仿 为溶剂， 生成 tert-butyl N-[2-[(7-methyl-1,8-naphthyridin-2-yl)amino]-2-oxoethyl]carbamate
  参考文献：
  名称：

  Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA

  摘要：

  DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one-electron oxidation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01189-2

文献信息

• Water-soluble 2-amino-1,8-naphthyridine as a novel DNA binding photosensitizer for one-electron oxidation of DNA
  作者：Kazuhiko Nakatani、Shinsuke Sando、Kohzo Yoshida、Isao Saito

  DOI：10.1016/s0040-4039(99)01189-2

  日期：1999.8

  DNA binding and photoinduced DNA cleaving properties of water-soluble naphthyridine derivative 1 were investigated. The photoinduced cleavage of DNA was studied by both PAGE and product analysis, indicating that the DNA cleavage proceeds via one-electron oxidation pathway. (C) 1999 Elsevier Science Ltd. All rights reserved.