N-(4-aminomethylbenzyl)acetamide | 62592-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-aminomethylbenzyl)acetamide
• 英文别名: N-{[4-(Aminomethyl)phenyl]methyl}acetamide；N-[[4-(aminomethyl)phenyl]methyl]acetamide
• CAS: 62592-05-6
• 化学式: C₁₀H₁₄N₂O
• 分子量: 178.234
• InChiKey: LMWLRQKZZZGYDQ-UHFFFAOYSA-N

物化性质

• 沸点：
  404.5±33.0 °C(Predicted)
• 密度：
  1.082±0.06 g/cm3(Predicted)
• 保留指数：
  2434

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  苄氧羰基-L-丙氨酸 、 N-(4-aminomethylbenzyl)acetamide 在 N,N-二异丙基乙胺 、 N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate 作用下， 以 乙腈 为溶剂， 反应 4.17h， 以76%的产率得到benzyl (S)-(1-((4-(acetamidomethyl)benzyl)amino)-1-oxopropan-2-yl)carbamate
  参考文献：
  名称：

  在中性pH下酰胺基团的快速选择性裂解：从透明质酸到小分子的应用

  摘要：

  仅使用几当量的三氟乙酸羟铵或碘化物就可以使仲酰胺键在中性pH值下裂解，对普通胺保护基和其他羰基官能团具有显着的选择性。

  DOI：

  10.1002/ejoc.201800304

文献信息

• 12-EPI PLEUROMUTILINS
  申请人：NABRIVA THERAPEUTICS AG

  公开号：US20160332963A1

  公开（公告）日：2016-11-17

  A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula processes for the preparation of such compounds and their use as pharmaceuticals.

  从14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-硫基)-乙酰基]-12-epi-木替林，或14-O-[((烷基、环烷基、杂环烷基、杂环芳基或芳基)-氧基)-乙酰基]-12-epi-木替林中选择的一种化合物，其中12-epi-木替林的特征在于木替林环在位置12被两个取代基取代，木替林环在位置12的第一个取代基是一个甲基基团，该甲基基团的立体化学与天然存在的普鲁木替林环在位置12的甲基基团的立体化学相反，木替林环在位置12的第二个取代基是一个含有至少一个氮原子的碳氢基团，木替林环的所有其他取代基与天然存在的普鲁木替林环中相应位置的取代基的立体化学相同；可选地以盐和/或溶剂的形式存在，其中天然存在的普鲁木替林的化学式为 制备这类化合物的方法以及它们作为药物的用途。
• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• Heterocyclic aspartyl protease inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：EP2343069B1

  公开（公告）日：2016-03-02
• NOVEL RHODAMINE DYES AND CONJUGATES
  申请人：Bremberg Ulf

  公开号：US20130096309A1

  公开（公告）日：2013-04-18

  The present invention relates generally to novel rhodamine dyes which upon conjugation with another molecule form single isomeric conjugation products. These novel rhodamine dyes contain only one single functional group on the rhodomine molecule for conjugation so that their conjugation products are single isomeric conjugation products.
• ACTINIC RADIATION-CURING TYPE INK COMPOSITION, INKJET RECORDING METHOD, DECORATIVE SHEET, DECORATIVE SHEET MOLDED PRODUCT, PROCESS FOR PRODUCING IN-MOLD MOLDED ARTICLE, AND IN-MOLD MOLDED ARTICLE
  申请人：FUJIFILM CORPORATION

  公开号：US20130260092A1

  公开（公告）日：2013-10-03

  Disclosed is an actinic radiation-curing type ink composition comprising (Component A) a monofunctional radically polymerizable monomer and (Component B) a polyfunctional acrylate oligomer having a glass transition temperature of no greater than 20° C. and having an acrylate equivalent of at least 300 g/eq, Component A comprising (Component A-1) an N-vinyl compound and (Component A-2) an acrylamide derivative, Component A having a content of at least 70 mass % of the entire ink composition, and Component A-1 having a content of at least 18 mass % of the entire ink composition.