ethyl decahydro-6-oxo-2-methoxycarbonyl-3-isoquinolinecarboxylate | 128073-42-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl decahydro-6-oxo-2-methoxycarbonyl-3-isoquinolinecarboxylate
• 英文别名: ethyl 2-Methoxycarbonyl-6-oxodecahydroisoquinoline-3-carboxylate；(-) ethyl 2-methoxycarbonyl-6-oxodecahydroisoquinoline-3-carboxylate；(-)-ethyl 2-methoxycarbonyl-6-oxodecahydroisoquinoline-3-carboxylate；ethyl 6-oxo-2-(methoxycarbonyl)-decahydroisoquinoline-3-carboxylate；3-Ethyl 2-Methyl 6-oxooctahydroisoquinoline-2,3(1H)-dicarboxylate；3-O-ethyl 2-O-methyl 6-oxo-1,3,4,4a,5,7,8,8a-octahydroisoquinoline-2,3-dicarboxylate
• CAS: 128073-42-7
• 化学式: C₁₄H₂₁NO₅
• 分子量: 283.324
• InChiKey: HAEQCUWBOVQMOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  72.9
• 氢给体数：
  0
• 氢受体数：
  5

安全信息

• 海关编码：
  2933499090

反应信息

• 作为反应物：
  描述：

  ethyl decahydro-6-oxo-2-methoxycarbonyl-3-isoquinolinecarboxylate 生成 3-O-ethyl 2-O-methyl (6Z)-6-(cyanomethylidene)-1,3,4,4a,5,7,8,8a-octahydroisoquinoline-2,3-dicarboxylate
  参考文献：
  名称：

  ORNSTEIN, PAUL L.

  摘要：

  DOI：
• 作为产物：
  描述：

  ethyl decahydro-6-hydroxy-2-methoxycarbonyl-3-isoquinolinecarboxylate 生成 ethyl decahydro-6-oxo-2-methoxycarbonyl-3-isoquinolinecarboxylate
  参考文献：
  名称：

  ORNSTEIN, PAUL L.

  摘要：

  DOI：

文献信息

• Excitatory amino acid receptor antagonists
  申请人：Eli Lilly and Company

  公开号：US04902695A1

  公开（公告）日：1990-02-20

  The present invention provides novel bicyclic derivatives useful as excitatory amino acid receptor antagonists and in treating a variety of associated nervous system disorders.

  本发明提供了一种新颖的双环衍生物，可用作兴奋性氨基酸受体拮抗剂，并用于治疗各种相关的神经系统疾病。
• EXCITATORY AMINO ACID RECEPTOR ANTAGONISTS
  申请人：Martinez-Perez Jose Antonio

  公开号：US20100094014A1

  公开（公告）日：2010-04-15

  The present invention provides novel compounds of Formula (I) and Formula (I(a)), or the pharmaceutically acceptable salts thereof; methods for treating neurological disorders and neurodegenerative diseases, particularly pain and migraine, comprising administering a compound of Formula (I) or Formula (I(a)); and processes for preparing compounds of Formula (I) or Formula (I(a)).

  本发明提供了公式（I）和公式（I（a））的新化合物，或其药学上可接受的盐；治疗神经系统疾病和神经退行性疾病的方法，特别是治疗疼痛和偏头痛，包括给予公式（I）或公式（I（a））的化合物；以及制备公式（I）或公式（I（a））化合物的过程。
• Process and intermediates for the preparation of excitatory amino acide receptor antagonists
  申请人：ELI LILLY AND COMPANY

  公开号：EP0599518A1

  公开（公告）日：1994-06-01

  The present invention provides novel intermediates which are useful for the preparation of excitatory amino acid receptor antagonists. Further provided is a process to enatioselectively prepare hydroisoquinoline compounds with central nervous system activity.

  本发明提供了可用于制备兴奋性氨基酸受体拮抗剂的新型中间体。本发明还提供了一种烯属选择性制备具有中枢神经系统活性的氢异喹啉化合物的工艺。
• Contact lens treating method and composition
  申请人：——

  公开号：US20030078171A1

  公开（公告）日：2003-04-24

  A method and composition for disinfecting a contact lens is disclosed. The method includes treating a lens with an aqueous solution having reduced toxicity to the eye which contains an effective amount of a monoperphthalic acid compound in a concentration of less than about 0.5% by weight of the solution. The lens disinfecting solution is capable of disinfecting contact lenses without irritating the eye due to reduced toxicity of the composition.

  本发明公开了一种为隐形眼镜消毒的方法和组合物。该方法包括用一种对眼睛毒性降低的水溶液处理镜片，该水溶液含有有效量的单邻苯二甲酸化合物，浓度小于溶液重量的约 0.5%。由于组合物的毒性降低，镜片消毒液能够在不刺激眼睛的情况下对隐形眼镜进行消毒。
• Decahydro isoquinoline derivatives, process for their preparation and use as medicines
  申请人：ELI LILLY AND COMPANY

  公开号：EP0383504B1

  公开（公告）日：1995-07-19