3,5-Dibrom-2,6-dimethoxybenzoesaeurechlorid | 89653-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5-Dibrom-2,6-dimethoxybenzoesaeurechlorid
• 英文别名: 2,6-dimethoxy-3,5-dibromobenzoyl chloride；3,5-Dibromo-2,6-dimethoxybenzoyl chloride
• CAS: 89653-84-9
• 化学式: C₉H₇Br₂ClO₃
• 分子量: 358.414
• InChiKey: IQZUBJDPGNLIKR-UHFFFAOYSA-N

物化性质

• 沸点：
  411.0±45.0 °C(Predicted)
• 密度：
  1.826±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5-Dibrom-2,6-dimethoxybenzoesaeurechlorid 在 盐酸 、 magnesium 作用下， 以 溶剂黄146 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Pudleiner, Heinz; Laatsch, Hartmut, Liebigs Annalen der Chemie, 1990, # 5, p. 423 - 432

  摘要：

  DOI：
• 作为产物：
  描述：

  2,6-二甲氧基苯甲酸 在 氯化亚砜 、 溴 、 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 0.5h， 生成 3,5-Dibrom-2,6-dimethoxybenzoesaeurechlorid
  参考文献：
  名称：

  Potential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities

  摘要：

  A series of some novel N-(l-ethyl-2-pyrrolidinylmethyl)benzamides was synthesized and tested for dopamine receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. The structure-activity relationships are discussed.

  DOI：

  10.1021/jm00353a003

文献信息

• Ferranti; Roberti; Garuti, Pharmazie, 1988, vol. 43, # 5, p. 359 - 360
  作者：Ferranti、Roberti、Garuti、Giovanninetti、Mannini Palenzona

  DOI：——

  日期：——
• FLORVALL, L.;PERSSON, M. -L.;OERGEN, S. -O., ACTA PHARM. SUEC., 1983, 20, N 5, 365-370
  作者：FLORVALL, L.、PERSSON, M. -L.、OERGEN, S. -O.

  DOI：——

  日期：——
• US5310739A
  申请人：——

  公开号：US5310739A

  公开（公告）日：1994-05-10
• US5432173A
  申请人：——

  公开号：US5432173A

  公开（公告）日：1995-07-11
• Potential neuroleptic agents. 2,6-Dialkoxybenzamide derivatives with potent dopamine receptor blocking activities
  作者：Lennart Florvall、Sven Ove Oegren

  DOI：10.1021/jm00353a003

  日期：1982.11

  A series of some novel N-(l-ethyl-2-pyrrolidinylmethyl)benzamides was synthesized and tested for dopamine receptor blockade in vivo by the ability to block the apomorphine syndrome in the rat. Several compounds were considerably more potent than sulpiride as dopamine receptor blockers and displayed low liability to induce extrapyramidal side effects (catalepsy) in the rat. The blockade of dopamine receptor activity in vivo was mainly confined to the levorotatory isomers having the S absolute configuration. The structure-activity relationships are discussed.