4-(硫代丙基)苯胺 1盐酸盐 | 22133-40-0

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 中文名称: 4-(硫代丙基)苯胺 1盐酸盐
• 中文别名: 4-(硫代丙基)苯胺1HCL；4-(硫代丙基)苯胺1盐酸盐
• 英文名称: 4-aminophenyl propyl sulphide
• 英文别名: 4-propylthiophenylamine；4-(propylthio)aniline；4-Propylthioanilin；4-propylsulfanyl-aniline；4-Amino-thiophenol-propylaether；Propyl-(4-amino-phenyl)-sulfid；4-Propylmercapto-anilin；4-propylsulfanylaniline
• CAS: 22133-40-0
• 化学式: C₉H₁₃NS
• 分子量: 167.275
• InChiKey: PZHFERQADHACDR-UHFFFAOYSA-N

物化性质

• 沸点：
  120-122 °C(Press: 0.09 Torr)
• 密度：
  1.06±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  51.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2930909090

反应信息

• 作为反应物：
  描述：

  4-(硫代丙基)苯胺 1盐酸盐 在 盐酸 、 氢氧化钾 、 ammonium hydroxide 、 氯化亚砜 、 copper(II) sulfate 、 sodium nitrite 作用下， 生成 4-propylsulfanyl-benzoic acid amide
  参考文献：
  名称：

  Buu-Hoi; Lecocq, Bulletin de la Societe Chimique de France, 1946, p. 475

  摘要：

  DOI：
• 作为产物：
  描述：

  1-propylthio-4-nitrobenzene 在 盐酸 、 tin 作用下， 反应 0.25h， 以85.6%的产率得到4-(硫代丙基)苯胺 1盐酸盐
  参考文献：
  名称：

  Sulfoxide-Containing Aromatic Nitrogen Mustards as Hypoxia-Directed Bioreductive Cytotoxins

  摘要：

  A series of diaryl and alkylaryl sulfoxide-containing nitrogen mustards were synthesized and evaluated for their hypoxia-selective cytotoxicity against V-79 cells in vitro as well as for their metabolism profiles with the rat S-9 fractions. In general, the diaryl sulfoxides (4, 5, and 7-9) showed much greater hypoxia selectivity (11-27-fold) than the alkylaryl sulfoxides (similar to3-fold) (1 and 3). The fused diphenyl sulfoxides (10 and 11), on the other hand, showed very low hypoxia selectivity (1.3-3-fold). Compound 10 was highly cytotoxic under both aerobic and anaerobic conditions, while 11 showed low cytotoxicity under both conditions. The bioreduction of 8 by the rat S-9 fraction under anaerobic conditions was inhibited by menadione and enhanced by benzaldehyde, acetaldehyde, or 2-hydroxypyrimidine suggesting the involvement of aldehyde oxidase in the reduction of the sulfoxides. Bioreductive metabolism studies of selected model sulfoxides suggested that diaryl sulfoxides are better substrates for aldehyde oxidase than alkylaryl sulfoxides.

  DOI：

  10.1021/jm9904957

文献信息

• Electrophilic Chlorine from Chlorosulfonium Salts: A Highly Chemoselective Reduction of Sulfoxides
  作者：Paola Acosta‐Guzmán、Camilo Mahecha‐Mahecha、Diego Gamba‐Sánchez

  DOI：10.1002/chem.202001815

  日期：2020.8.12

  deoxygenation of sulfoxides based on a novel application of chlorosulfonium salts and demonstrate a new process using these species generated in situ from sulfoxides as the source of electrophilic chlorine. The use of highly nucleophilic 1,3,5‐trimethoxybenzene (TMB) as the reducing agent is described for the first time and applied in the deoxygenation of simple and functionalized sulfoxides. The method

  本文中，我们基于氯ulf盐的新应用描述了亚砜的选择性后期脱氧，并展示了使用这些亚砜原位生成的物种作为亲电氯源的新工艺。首次描述了使用高度亲核的1,3,5-三甲氧基苯（TMB）作为还原剂，并将其用于简单和功能化亚砜的脱氧。该方法易于操作，经济，适用于克级操作，并且易于应用于多官能分子，如超过45个实例（包括商业药物和类似物）所示。我们还报告了定义更具反应性的亚砜的竞争实验的结果，并且我们根据底物和产品的观察结果提出了一种机械的方案。
• 1,3-dicarboxamide-oxindoles as antiinflammatory agents
  申请人：Pfizer Inc.

  公开号：US04725616A1

  公开（公告）日：1988-02-16

  1,3-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.

  1,3-二羧酰胺氧吲哚是一种抗炎药物，通过1-氨甲酰氧吲哚与异氰酸酯反应或相应的烷基1-氨甲酰氧吲哚-3-羧酸酯的氨解反应制备。
• 1,3-dicarboxamidooxindoles as analgesic and antiinflammatory agents
  申请人：Pfizer Inc.

  公开号：US04791129A1

  公开（公告）日：1988-12-13

  1,3,-Dicarboxamidooxindoles as antiinflammatory agents prepared by reaction of the 1-carbamoyloxindole with an isocyanate or by aminolysis of the corresponding alkyl 1-carbamoyloxindole-3-carboxylate.

  1,3-二羧酰胺氧吲哚作为抗炎药物，通过1-氨甲酰氧吲哚与异氰酸酯反应或相应的烷基1-氨甲酰氧吲哚-3-羧酸酯的氨解反应制备。
• 1-Substituted oxindole-3-carboxamines as antiinflammatory and analgesic agents
  申请人：PFIZER INC.

  公开号：EP0208510A2

  公开（公告）日：1987-01-14

  A series of 1-substituted oxindole-3-carboxamide compounds are useful as antiinflammatory and analgesic agents in mammalian subjects. The compounds of the invention can be prepared by (1) reaction of the appropriate 1-substituted oxindole with an isocyanate or (2) aminolysis of the alkyl ester of the appropriate 1-substituted oxindole-3-carboxylate.

  一系列 1-取代吲哚-3-甲酰胺化合物可用作哺乳动物的抗炎和镇痛剂。本发明的化合物可通过以下方法制备：(1) 适当的 1-取代吲哚与异氰酸酯反应，或 (2) 适当的 1-取代吲哚-3-甲酸烷基酯的氨基化反应。
• THERMALLY CONDUCTIVE MATERIAL, DEVICE PROVIDED WITH THERMALLY CONDUCTIVE LAYER, THERMALLY CONDUCTIVE MATERIAL FORMATION COMPOSITION, DISC-SHAPED LIQUID CRYSTAL COMPOUND
  申请人：FUJIFILM Corporation

  公开号：EP3653660A1

  公开（公告）日：2020-05-20

  The present invention provides a thermally conductive material having excellent thermal conductivity. Furthermore, the present invention provides a device with a thermally conductive layer that has a thermally conductive layer containing the thermally conductive material and a composition for forming a thermally conductive material that is used for forming the thermally conductive material. The thermally conductive material according to an embodiment of the present invention contains a cured substance of a disk-like compound, which has one or more reactive functional groups selected from the group consisting of a hydroxyl group, a carboxylic acid group, a carboxylic acid anhydride group, an amino group, a cyanate ester group, and a thiol group, and a crosslinking compound which has a group reacting with the reactive functional groups.

  本发明提供了一种具有优异导热性能的导热材料。此外，本发明还提供了一种具有导热层的设备，该设备具有包含该导热材料的导热层和用于形成导热材料的导热材料组合物。根据本发明一个实施例的导热材料含有盘状化合物的固化物，该固化物具有一个或多个反应性官能团，这些反应性官能团选自由羟基、羧酸基、羧酸酐基、氨基、氰酸酯基和硫醇基组成的组，以及具有与反应性官能团反应的基团的交联化合物。