2-hydroxyheptadecanoic acid | 25022-78-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxyheptadecanoic acid
• 英文别名: 2-hydroxy-heptadecanoic acid；1-Hydroxy-hexadecan-carbonsaeure-(1)；2-Hydroxy-heptadecansaeure；2-Hydroxy-margarinsaeure；α-Oxy-hexadecan-α-carbonsaeure；α-Oxy-margarinsaeure
• CAS: 25022-78-0
• 化学式: C₁₇H₃₄O₃
• 分子量: 286.455
• InChiKey: KUZABABLVHWUGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  20
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-hydroxyheptadecanoic acid 生成 十六醛
  参考文献：
  名称：

  Le Sueur, Journal of the Chemical Society, 1905, vol. 87, p. 1901

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氢氧化钾 作用下， 生成 2-hydroxyheptadecanoic acid
  参考文献：
  名称：

  Le Sueur, Journal of the Chemical Society, 1904, vol. 85, p. 833

  摘要：

  DOI：

文献信息

• Lipids That Increase Insulin Sensitivity And Methods Of Using The Same
  申请人：BETH ISRAEL DEACONESS MEDICAL CENTER, INC.

  公开号：US20160221925A1

  公开（公告）日：2016-08-04

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders—including diabetes-related disorders, Metabolic Syndrome, polycystic ovarian syndrome, cancer, and inflammatory disorders—using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  该发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于诊断和治疗各种疾病的方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病等；以及筛选可用于治疗这些疾病和/或调节FAHFA水平、FAHFA介导信号传导和FAHFA介导生物效应的其他化合物的方法。
• [EN] LIPIDS THAT INCREASE INSULIN SENSITIVITY AND METHODS OF USING THE SAME<br/>[FR] LIPIDES AUGMENTANT LA SENSIBILITÉ À L'INSULINE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BETH ISREAL DEACONESS MEDICAL CT INC

  公开号：WO2013166431A1

  公开（公告）日：2013-11-07

  The invention provides, inter alia, fatty acyl hydroxy fatty acid (FAHFA; a novel class of estolide-related molecules) and diagnostic and treatment methods for a variety of disorders- including diabetes-related disorders, Metabolic Syndrome, polycyctic ovarian syndrome, cancer, and inflammatory disorders— using them; as well as methods of screening for additional compounds that are useful in treating these disorders and/or that modulate FAHFA levels, FAHFA-mediated signaling, and FAHFA-mediated biological effects.

  这项发明提供了脂肪酰羟基脂肪酸（FAHFA；一类新型的酯脂类分子）以及用于治疗各种疾病的诊断和治疗方法，包括与糖尿病相关的疾病、代谢综合征、多囊卵巢综合征、癌症和炎症性疾病，以及使用它们的方法；以及筛选对这些疾病有用或调节FAHFA水平、FAHFA介导的信号传导和FAHFA介导的生物效应的其他化合物的方法。
• COMPOSITIONS COMPRISING POLYMERS PREPARED FROM 2-HYDROXYALKYL ACIDS
  申请人：Moeller Michael

  公开号：US20130131190A1

  公开（公告）日：2013-05-23

  Described herein are compositions comprising polymers prepared by melt polycondensation of 2-hydroxyalkyl acids. Methods of making and using the compositions are also disclosed.

  本文描述了由2-羟基烷基酸熔融缩聚制备的聚合物组成物。还公开了制备和使用该组成物的方法。
• METHODS FOR PRODUCING DICARBOXYLIC ACIDS
  申请人：Synthetic Genomics, Inc.

  公开号：US20150176041A1

  公开（公告）日：2015-06-25

  The present invention provides methods of producing dicarboxylic acids. The methods involve incubating a fatty acid or hydrocarbon substrate with an enzyme to produce a dicarboxylic acid product. The enzyme acts on the substrate to produce a product that has been both over-oxidized and has undergone cleavage of a C—C bond. In some embodiments the enzymes having these useful characteristics are mutants of a cytochrome P450 enzyme, for example an enzyme of the class CYP102 or a mutant thereof. The invention provides enzymes where these desirable characteristics can be found in a single enzyme, and thus in some embodiments the methods can be performed through the action of a single enzyme.

  本发明提供了生产二羧酸的方法。该方法涉及将脂肪酸或烃基底物与酶孵育以生产二羧酸产物。酶作用于底物以产生经过过氧化和C-C键断裂的产物。在某些实施例中，具有这些有用特性的酶是细胞色素P450酶的突变体，例如CYP102类酶或其突变体。本发明提供了这些理想特性可以在单个酶中找到的酶，因此在某些实施例中，可以通过单个酶的作用来执行该方法。
• Cosmetic composition comprising at least one semi-crystalline polymer, and at least one ester of dimer diol and of acid
  申请人：Lebre Caroline

  公开号：US20050287101A1

  公开（公告）日：2005-12-29

  The present disclosure relates to a cosmetic composition comprising at least one ester of dimer diol and of at least one acid chosen from dicarboxylic and C 4 to C 34 monocarboxylic acids, and at least one semi-crystalline polymer with an organic structure, wherein the at least one semi-crystalline polymer has a melting point greater than or equal to 30° C.

  本公开涉及一种化妆品组合物，包括至少一种双聚二醇酯和至少一种二羧酸和C4到C34单羧酸中选择的酸的酯类，以及至少一种具有有机结构的半晶态聚合物，其中该至少一种半晶态聚合物的熔点大于或等于30℃。