N-benzoyl-N'-(cyclohexylmethyl)thiourea | 145012-90-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzoyl-N'-(cyclohexylmethyl)thiourea
• 英文别名: N-(cyclohexylmethylcarbamothioyl)benzamide
• CAS: 145012-90-4
• 化学式: C₁₅H₂₀N₂OS
• 分子量: 276.403
• InChiKey: IGCNOPZPKGOEPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  73.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-benzoyl-N'-(cyclohexylmethyl)thiourea 在 盐酸 、 水 、 sodium hydride 、 potassium carbonate 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 生成 N-Butyl-3-(N'-cyclohexylmethyl-guanidino)-2-methyl-propionamide; hydrochloride
  参考文献：
  名称：

  一种温和有效的胍类制备方法

  摘要：

  报道了一种温和有效的制备胍的方法，该方法是通过使酰化的硫脲与胺反应，然后从中间体酰基胍中除去酰基。

  DOI：

  10.1016/s0040-4039(00)61092-4
• 作为产物：
  描述：

  苯甲酰基异硫氰酸酯 、 环己甲胺 以 氯仿 为溶剂， 生成 N-benzoyl-N'-(cyclohexylmethyl)thiourea
  参考文献：
  名称：

  一种温和有效的胍类制备方法

  摘要：

  报道了一种温和有效的制备胍的方法，该方法是通过使酰化的硫脲与胺反应，然后从中间体酰基胍中除去酰基。

  DOI：

  10.1016/s0040-4039(00)61092-4

文献信息

• Isothiourea analogues of histamine as potent agonists or antagonists of the histamine H3-receptor
  作者：H van der Goot、MJP Schepers、GJ Sterk、H Timmerman

  DOI：10.1016/0223-5234(92)90185-4

  日期：1992.8

  The synthesis and H-3-activity of a series of isothiourea analogues of histamine have been described. It has been shown that S-[2-(4(5)-imidazolyl)ethylisothiourea (VUF 8325) is a potent H-3-agonist measured as the electrically evoked contraction of the guinea-pig ileum. Upon methylation of the imidazole system or the isothiourea moiety a decrease in affinity was observed leading to either weak agonists or weak antagonists. Introduction of N-(phenylalkyl) substituents at the isothiourea part gives rise to highly potent H-3-antagonists. Particularly the 4-chlorobenzyl group appeared to be favourable in the series described resulting in a histamine H-3-antagonist with a pA2-value of 9.9.
• SELECTIVE NPY (Y5) ANTAGONISTS
  申请人：SYNAPTIC PHARMACEUTICAL CORPORATION

  公开号：EP1194421A1

  公开（公告）日：2002-04-10
• EP1194421A4
  申请人：——

  公开号：EP1194421A4

  公开（公告）日：2002-09-11
• [EN] SELECTIVE NPY (Y5) ANTAGONISTS<br/>[FR] ANTAGONISTES SELECTIFS DU NPY (Y5)
  申请人：SYNAPTIC PHARMA CORP

  公开号：WO2001002379A1

  公开（公告）日：2001-01-11

  This invention is directed to bicyclic and tricyclic compounds which are selective antagonists for NPY (Y5) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of a compound of this invention and a pharmaceutically acceptable carrier. The invention provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides the use of a compound of the invention for the preparation of a pharmaceutical composition for treating an abnormality, wherein the abnormality is alleviated by decreasing the activity of a human Y5 receptor.