Synthesis and pharmacological evaluation of prenylated and benzylated pterocarpans against snake venom
作者:Alcides J.M. da Silva、Antonio L. Coelho、Alessandro B.C. Simas、Raphael A.M. Moraes、Diogo A. Pinheiro、Fabrı́cio F.A. Fernandes、Emerson Z. Arruda、Paulo R.R. Costa、Paulo A. Melo
DOI:10.1016/j.bmcl.2003.10.044
日期:2004.1
Edunol (3), a pterocarpan isolated from Harpalyce brasiliana, a plant used in the northeast of Brazil against snakebites, was obtained by synthesis and showed antimyotoxic, antiproteolytic and PLA2 inhibitor properties. These proprieties could be improved through the synthesis of a bioisoster (5), where the prenyl group was replaced by the benzyl group. (C) 2003 Elsevier Ltd. All rights reserved.