benzophenone O-(chloroformyl)oxime | 18304-44-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzophenone O-(chloroformyl)oxime
• 英文别名: benzophenone O-chlorocarbonyloxime；Benzophenon-O-chloroformyloxim；Benzophenon-oxim-chloroformat；Chlorcarbonyl-benzophenonoxim；(benzhydrylideneamino) carbonochloridate
• CAS: 18304-44-4
• 化学式: C₁₄H₁₀ClNO₂
• 分子量: 259.692
• InChiKey: AQHXLTAYMNQGLT-UHFFFAOYSA-N

物化性质

• 熔点：
  34-36 °C
• 沸点：
  370.4±25.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  38.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  benzophenone O-(chloroformyl)oxime 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 生成 diphenylmethanone O-(1-phenylethyl) oxime
  参考文献：
  名称：

  Ruechardt,C.; Pantke,R., Chemische Berichte, 1971, vol. 104, p. 3456 - 3462

  摘要：

  DOI：
• 作为产物：
  描述：

  二苯甲酮肟 、 Carbonic acid ditrichloromethyl ester; compound with pyridine 以 吡啶 、 苯 为溶剂， 以57%的产率得到benzophenone O-(chloroformyl)oxime
  参考文献：
  名称：

  A Convenient Procedure for the Preparation of Oxime Chloroformates

  摘要：

  Triphosgene is a convenient reagent for the preparation of O-(chloroformyl)oximes from aliphatic and aromatic ketoximes.

  DOI：

  10.1081/scc-120023999

文献信息

• Preparation and Beckmann Rearrangement of<i>O</i>-(Chlorooxalyl)oximes
  作者：Johannes C. Jochims、Sabine Hehl、Siegfried Herzberger

  DOI：10.1055/s-1990-27112

  日期：——

  Oximes 1 react with phosgene or oxalyl chloride to give O-(chloroformyl)- 2, or O-(chlorooxalyl) oximes 8, which undergo Beckmann rearrangement with antimony pentachloride to afford nitrilium hexachloroantimonates 3 in high yields. With di- or triphosgene (4 or 6) oximes 1 form mixtures of O-(chloroformyl)- 2 and O-(trichloromethoxyformyl)oximes 5. The O-(chlorooxalyl)oximes 8 further characterized as esters 10 and amides 11. With N,N-dimethylformamide the nitrilium salts 3 react to give N-acyl formamidinium salts 12.

  Oxime 1 与氯甲酰或草酰氯反应，生成 O-(氯甲酰)-2 或 O-(氯草酰)oxime 8，这些产物在五氯化锑的作用下发生贝克曼重排，得到高产率的六氯锑阳离子盐 3。与二氯或三氯甲酸酯（4 或 6）反应，oxime 1 形成 O-(氯甲酰)-2 和 O-(三氯甲氧基甲酰)oxime 5 的混合物。O-(氯草酰)oxime 8 进一步被表征为酯 10 和酰胺 11。与 N,N-二甲基甲酰胺反应，阳离子盐 3 产生 N-酰基苯甲铵盐 12。
• Carbonic acid esters, and the preparation thereof and their use
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04010178A1

  公开（公告）日：1977-03-01

  Carbonic acid esters of the formula substituent(s) substituents(s) R'.sub.1 OCOOR'.sub.2 wherein R'.sub.1 is lower alkyl which may have substituent)s) selected from the group of halogen, lower alkoxy and aryloxy, or ar(lower)-alkyl which may have substituents)s) selected from the group of lower alkoxy, halogen, nitro and cyano, and R'.sub.2 is benzotriazolyl which may have halogen; or a group represented by the formula: ##STR1## wherein Y' and Z' are each cyano, nitro, carbamoyl, esterified carboxy, lower alkanoyl, aroyl or disubstituted carbamoyl; provided that when R'.sub.2 is a group represented by the formula: ##STR2## wherein Y' and Z' are each cyano, nitro, carbamoyl or esterified carboxy, R'.sub.1 is ar(lower) alkyl having substituent(s) selected from the group of lower alkoxy, halogen, nitro and cyano. A process for the protection of amino and/or imino groups in compounds containing them by reacting them with the aforementioned esters is also disclosed.

  化学式为R'.sub.1 OCOOR'.sub.2，其中R'.sub.1为低级烷基，可以具有取自卤素、低级烷氧基和芳基氧基的取代基，或为芳基(低级)-烷基，可以具有取自低级烷氧基、卤素、硝基和氰基的取代基；R'.sub.2为苯并三唑基，可以具有卤素；或为公式所示的基团：##STR1## 其中Y'和Z'均为氰基、硝基、氨基甲酰基、酯化羧基、低级烷酰基、芳酰基或二取代氨基甲酰基；但当R'.sub.2为公式所示的基团：##STR2## 其中Y'和Z'均为氰基、硝基、氨基甲酰基或酯化羧基时，R'.sub.1为芳基(低级)烷基，具有取自低级烷氧基、卤素、硝基和氰基的取代基。还公开了一种通过与上述酯反应来保护含有氨基和/或亚氨基基团的化合物的方法。
• Oxime carbonates
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04014915A1

  公开（公告）日：1977-03-29

  Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.

  本发明揭示了一种新型碳酸酯，其可用于在氨基和/或亚氨基含有化合物中引入酯化羧基型保护基的过程中，对所述氨基和/或亚氨基进行临时保护。此外，本发明还揭示了制备所述酯的过程。
• Compact floribunda rose plant named ‘Poulpal077’
  申请人：Olesen Mogens Nyegaard

  公开号：USPP030752P3

  公开（公告）日：2019-07-30

  A new garden rose plant of the Compact Floribunda class which has abundant, pink flowers and attractive foliage. This new and distinct variety has shown to be uniform and stable in the resulting generations from asexual propagation.

  一种新的紧凑型多花蔷薇植物，拥有丰富的粉色花朵和吸引人的叶子。这个新的独特品种已经证明在无性繁殖的后代中是均匀和稳定的。
• Process for protecting amino and/or imino groups
  申请人：Fujisawa Pharmaceutical Co., Ltd.

  公开号：US04083848A1

  公开（公告）日：1978-04-11

  Novel carbonic acid esters are disclosed which are useful in a process for introducing esterified carboxy-type protective groups on amino and/or imino groups in amino and/or imino group - containing compounds for the temporary protection of said amino and/or imino groups. Additionally, processes for preparing said esters are also disclosed.

  本发明揭示了一种新型的碳酸酯，可用于在含有氨基和/或亚氨基的化合物中引入酯化羧基型保护基的过程中，对所述氨基和/或亚氨基进行暂时保护。此外，本发明还揭示了制备所述酯的方法。