N-Benzyl-N-methanesulfonyl-2-methylpropanamide | 197958-50-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-Benzyl-N-methanesulfonyl-2-methylpropanamide
• 英文别名: N-benzyl-2-methyl-N-methylsulfonylpropanamide
• CAS: 197958-50-2
• 化学式: C₁₂H₁₇NO₃S
• mdl: MFCD11500219
• 分子量: 255.338
• InChiKey: UAQRFOLLAQWXET-UHFFFAOYSA-N

物化性质

• 沸点：
  381.3±35.0 °C(Predicted)
• 密度：
  1.192±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.416
• 拓扑面积：
  62.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-Benzyl-N-methanesulfonyl-2-methylpropanamide 在 萘 、 水 、 lithium 作用下， 生成 N-苄基-2-甲基丙酰胺
  参考文献：
  名称：

  Reductive deprotection of allyl, benzyl and sulfonyl substituted alcohols, amines and amides using a naphthalene-catalysed lithiation

  摘要：

  The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00920-4
• 作为产物：
  描述：

  N-benzyl-N-(methylsulfonyl)acetamide 在 正丁基锂 、 萘 、 水 、 lithium 作用下， 反应 0.5h， 生成 N-Benzyl-N-methanesulfonyl-2-methylpropanamide
  参考文献：
  名称：

  Reductive deprotection of allyl, benzyl and sulfonyl substituted alcohols, amines and amides using a naphthalene-catalysed lithiation

  摘要：

  The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4020(97)00920-4

文献信息

• Reductive deprotection of allyl, benzyl and sulfonyl substituted alcohols, amines and amides using a naphthalene-catalysed lithiation
  作者：Emma Alonso、Diego J. Ramón、Miguel Yus

  DOI：10.1016/s0040-4020(97)00920-4

  日期：1997.10

  The reaction of different protected alcohols, amines and amides with lithium and a catalytic amount of naphthalene (4 mol %) in THF at low temperature leads to their deprotection under very mild reaction conditions, the process being in many cases chemoselective. (C) 1997 Elsevier Science Ltd.