N-methyl-4-N-[6-(N-phthalimido)hexyl]aminophthalimide | 73819-86-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-methyl-4-N-[6-(N-phthalimido)hexyl]aminophthalimide
• 英文别名: 5-{[6-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)hexyl]amino}-2-methyl-1H-isoindole-1,3(2H)-dione；5-[6-(1,3-dioxoisoindol-2-yl)hexylamino]-2-methylisoindole-1,3-dione
• CAS: 73819-86-0
• 化学式: C₂₃H₂₃N₃O₄
• 分子量: 405.453
• InChiKey: ZCQFCHBIOXJVRI-UHFFFAOYSA-N

物化性质

• 熔点：
  169-170 °C(Solv: acetic acid (64-19-7))
• 沸点：
  620.4±40.0 °C(Predicted)
• 密度：
  1.337±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  30
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  86.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  硫酸二乙酯 、 N-methyl-4-N-[6-(N-phthalimido)hexyl]aminophthalimide 反应 2.33h， 以58%的产率得到4-[N-ethyl-N-(6-N-phthalimido)hexyl]amino-N-methylphthalimide
  参考文献：
  名称：

  Synthesis of novel isoluminol probes and their use in rapid bacterial assays

  摘要：

  Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol (14) and GluGlu-isoluminol (16) probes that have been derived from peptides which potentially mimic bacteriophage attachment protein binding regions. Compared to two conventional methods that are widely used, namely nucleic acid probes and polymerase chain reaction (PCR) assays, these types of probes may eventually have certain advantages, such as high sensitivity, and short preparation and assay time. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.004
• 作为产物：
  描述：

  N-甲基-4-氨基邻苯二甲酰亚胺 、 N-(6-溴己基)邻苯二甲酰亚胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 30.0h， 以49%的产率得到N-methyl-4-N-[6-(N-phthalimido)hexyl]aminophthalimide
  参考文献：
  名称：

  Synthesis of novel isoluminol probes and their use in rapid bacterial assays

  摘要：

  Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol (14) and GluGlu-isoluminol (16) probes that have been derived from peptides which potentially mimic bacteriophage attachment protein binding regions. Compared to two conventional methods that are widely used, namely nucleic acid probes and polymerase chain reaction (PCR) assays, these types of probes may eventually have certain advantages, such as high sensitivity, and short preparation and assay time. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.004

文献信息

• Synthesis of novel isoluminol probes and their use in rapid bacterial assays
  作者：Sundar Neelakantan、Iwan Surjawan、Huseyin Karacelik、Clair L. Hicks、Peter A. Crooks

  DOI：10.1016/j.bmcl.2009.08.004

  日期：2009.10

  Rapid assays for bacteria have been developed utilizing novel LysLysLys-isoluminol (14) and GluGlu-isoluminol (16) probes that have been derived from peptides which potentially mimic bacteriophage attachment protein binding regions. Compared to two conventional methods that are widely used, namely nucleic acid probes and polymerase chain reaction (PCR) assays, these types of probes may eventually have certain advantages, such as high sensitivity, and short preparation and assay time. (C) 2009 Elsevier Ltd. All rights reserved.