6-((diisopropylamino)methyl)picolinaldehyde | 1426427-83-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-((diisopropylamino)methyl)picolinaldehyde
• 英文别名: 6-[[Di(propan-2-yl)amino]methyl]pyridine-2-carbaldehyde
• CAS: 1426427-83-9
• 化学式: C₁₃H₂₀N₂O
• 分子量: 220.315
• InChiKey: UKESTJPBDWRDHF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  33.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-((diisopropylamino)methyl)picolinaldehyde 、 叔丁胺 以 乙醇 为溶剂， 以99%的产率得到(E)-2-(tert-butyliminomethyl)-6-diisopropylaminomethylpyridine
  参考文献：
  名称：

  Bifunctional iridium-(2-aminoterephthalate)–Zr-MOF chemoselective catalyst for the synthesis of secondary amines by one-pot three-step cascade reaction

  摘要：

  A simple and efficient method for the synthesis of N-alkyl amines via a cascade reaction (hydrogenation + reductive amination) using a new recyclable hybrid catalyst that combines the catalytic power of transition metal complexes with the architecture of metal organic frameworks (MOFs). (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jcat.2012.12.004
• 作为产物：
  描述：

  在 草酰氯 、 二甲基亚砜 作用下， 生成 6-((diisopropylamino)methyl)picolinaldehyde
  参考文献：
  名称：

  Bifunctional iridium-(2-aminoterephthalate)–Zr-MOF chemoselective catalyst for the synthesis of secondary amines by one-pot three-step cascade reaction

  摘要：

  A simple and efficient method for the synthesis of N-alkyl amines via a cascade reaction (hydrogenation + reductive amination) using a new recyclable hybrid catalyst that combines the catalytic power of transition metal complexes with the architecture of metal organic frameworks (MOFs). (C) 2012 Elsevier Inc. All rights reserved.

  DOI：

  10.1016/j.jcat.2012.12.004

文献信息

• Design of a Bifunctional Ir-Zr Based Metal-Organic Framework Heterogeneous Catalyst for the N-Alkylation of Amines with Alcohols
  作者：A. M. Rasero-Almansa、A. Corma、M. Iglesias、F. Sánchez

  DOI：10.1002/cctc.201402101

  日期：2014.6

  The direct N‐alkylation of amines with alcohols was performed with an Ir‐Zr‐based metal–organic framework multifunctional heterogeneous catalyst. This system is efficient and environmentally benign for the synthesis of various organic amines in air in the absence of a base. The catalyst was recovered and reused without significant loss of activity, and only water was produced as a byproduct.

  胺与醇的直接N-烷基化反应是基于Ir-Zr基金属-有机骨架多功能非均相催化剂进行的。该系统对于在不存在碱的情况下在空气中合成各种有机胺是有效且对环境无害的。回收催化剂并重新使用，而活性没有明显损失，仅产生水作为副产物。