N-<3-(diethylamino)propyl>-4-nitrobenzene | 34334-29-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<3-(diethylamino)propyl>-4-nitrobenzene
• 英文别名: 3-Diethylamino-1-(4-nitro-phenyl)-propan；N,N-diethyl-3-(p-nitrophenyl)-propylamine；N,N-diethyl-3-(4-nitrophenyl)propan-1-amine
• CAS: 34334-29-7
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.314
• InChiKey: SYFRZEXYXXUWMG-UHFFFAOYSA-N

物化性质

• 沸点：
  133-135 °C(Press: 0.25 Torr)
• 密度：
  1.055±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  49.1
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-<3-(diethylamino)propyl>-4-nitrobenzene 在 platinum on activated charcoal 盐酸 、 氢气 作用下， 以 甲醇 为溶剂， 反应 0.5h， 生成 9-({4-[(N,N-diethylamino)propyl]phenyl}amino)acridine
  参考文献：
  名称：

  Structure−Activity Relationships for the Antileishmanial and Antitrypanosomal Activities of 1‘-Substituted 9-Anilinoacridines

  摘要：

  Members of the class of 9-anilinoacridine topoisomerase II inhibitors bearing lipophilic electron-donating 1'-anilino substituents are active against both the promastigote and amastigote forms of the parasite Leishmania major. A series of analogues of the known 1'-NHhexyl lead compound were prepared and evaluated against L. major in macrophage culture to further develop structure-activity relationships (SAR). Toxicity toward mammalian cells was measured in a human leukemia cell line, and the ratio of the two IC50 values (IC50(J)/IC50(L)) was used as a measure of the in vitro therapeutic index (IVTI). A 3,6-diNMe(2) substitution pattern on the acridine greatly increased toxicity to L. major without altering mammalian toxicity, increasing IVTIs over that of the lead compound. The 2-OMe, 6-Cl acridine substitution pattern used in the antimalarial drug mepacrine also resulted in potent antileishmanial activity and high IVTIs. Earlier suggestions of the utility of 2'-OR groups in lowering mammalian cytotoxicity were not borne out in this wider study. A series of very lipophilic 1'-NRR (symmetric dialkylamino)-substituted analogues showed relatively high antileishmanial potency, but no clear trend was apparent across the series, and none were superior to the 1'-NH(CH2)(5)Me subclass. Subsets of the most active 1'-N(R)(CH2)(5)Me- and 1'-N(alkyl)(2)-substituted compounds against L. major were also evaluated against Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei, but no consistent SAR could be discerned in these physiologically diverse test systems. The present study has confirmed earlier conclusions that lipophilic electron-donating groups at the 1'-position of 9-anilinoacridines provide high activity against L. major, but the SAR patterns observed do not carry over to the other parasites studied.

  DOI：

  10.1021/jm970232h
• 作为产物：
  描述：

  1-氯-3-苯基丙烷 以 乙醇 为溶剂， 生成 N-<3-(diethylamino)propyl>-4-nitrobenzene
  参考文献：
  名称：

  一些芳氧基烷基胺，N-芳基乙二胺和相关化合物作为厌食剂。

  摘要：

  DOI：

  10.1021/jm00291a015

文献信息

• Amide inhibitors of microsomal triglyceride transfer protein
  申请人：——

  公开号：US20020156281A1

  公开（公告）日：2002-10-24

  The present invention provides compounds having the Formula I 1 The present invention also provides pharmaceutical compositions comprising a compound of Formula I and methods of treatment of atherosclerosis, obesity, restenosis, coronary heart disease, hyperlipoproteinemia, hypercholesterolemia, and hypertriglyceridemia.

  本发明提供具有化学式I的化合物。本发明还提供包含化合物I的药物组合物，以及治疗动脉粥样硬化、肥胖症、再狭窄、冠心病、高脂蛋白血症、高胆固醇血症和高甘油三酯血症的方法。
• Shape-preserving polymeric replication of biological matter
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US10947349B2

  公开（公告）日：2021-03-16

  The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).

  本发明涉及一种在生物样品上或生物样品内形成二氧化硅纳米层的方法，从而捕捉样品中存在的结构细节。由此产生的二氧化硅复合材料或二氧化硅复制品反过来可用作模板，用于在聚合物中捕获这些结构细节的复制品。本文还提供了包括聚合物复制品在内的合成构造物，它可以具有任何有用的特征（如氧结合能力）。
• SHAPE-PRESERVING POLYMERIC REPLICATION OF BIOLOGICAL MATTER
  申请人：National Technology & Engineering Solutions of Sandia, LLC

  公开号：US20200115507A1

  公开（公告）日：2020-04-16

  The present invention relates to a method of forming silica nanolayers on or within a biological sample, thereby capturing structural details that are present in the sample. The resultant silica composite or silica replica, in turn, can be employed as a template for a replica having those structural details captured in a polymer. Also provided herein are synthetic constructs including a polymeric replica, which can have any useful feature (e.g., oxygen-binding capacity).
• US6780883B2
  申请人：——

  公开号：US6780883B2

  公开（公告）日：2004-08-24
• US9989447B1
  申请人：——

  公开号：US9989447B1

  公开（公告）日：2018-06-05