N'-(diphenylmethylene)benzenesulfonohydrazide | 78119-51-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-(diphenylmethylene)benzenesulfonohydrazide
• 英文别名: N'-(diphenylmethylene)benzenesulfonohydrazide；benzenesulfonic acid benzhydrylidenehydrazide；Benzolsulfonsaeure-benzhydrylidenhydrazid；N-(benzhydrylideneamino)benzenesulfonamide
• CAS: 78119-51-4
• 化学式: C₁₉H₁₆N₂O₂S
• 分子量: 336.414
• InChiKey: IZNUJWMVEWFEKW-UHFFFAOYSA-N

物化性质

• 沸点：
  505.4±33.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

   N'-(diphenylmethylene)benzenesulfonohydrazide 在 copper(l) iodide 、 potassium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以80%的产率得到[苯磺酰基(苯基)甲基]苯
  参考文献：
  名称：

  铜催化的磺酰hydr氮损失：一种从羰基化合物合成砜的还原策略

  摘要：

  描述了一种通过磺酰基的氮损失合成砜的有效方法。该反应在简单的铜盐和碱的存在下通过利用磺酰基来进行，所述磺酰基易于从羰基化合物制备。以中等至良好的产率获得了各种各样的芳基和烷基砜。

  DOI：

  10.1021/ol101955x
• 作为产物：
  描述：

  二苯甲酮 、 苯磺酰肼 在 盐酸 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成  N'-(diphenylmethylene)benzenesulfonohydrazide
  参考文献：
  名称：

  铜催化的磺酰hydr氮损失：一种从羰基化合物合成砜的还原策略

  摘要：

  描述了一种通过磺酰基的氮损失合成砜的有效方法。该反应在简单的铜盐和碱的存在下通过利用磺酰基来进行，所述磺酰基易于从羰基化合物制备。以中等至良好的产率获得了各种各样的芳基和烷基砜。

  DOI：

  10.1021/ol101955x

文献信息

• Rubber composition and pneumatic tires
  申请人：Bridgestone Corporation

  公开号：US06380288B1

  公开（公告）日：2002-04-30

  A rubber composition prepared by compounding 0.05 to 20 parts by weight of at least one selected from substituted hydrazide compounds represented by the following Formulas (I) to (IV) per 100 parts by weight of a rubber component comprising at least one rubber selected from the group consisting of natural rubber and synthetic rubber, and a pneumatic tire using the same: wherein A represents one selected from the group consisting of an aromatic group which may have a substituent, a hydantoin ring which may have a substituent, and a saturated or unsaturated linear hydrocarbon having 1 to 18 carbon atoms; Y represents hydrogen, an amino group, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group, an aromatic group, a pyridyl group or hydrazino group; and R1 to R11 each represent hydrogen, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group or an aromatic group.

  一种橡胶组合物，其通过将以下式子（I）到（IV）中的至少一种取代肼化合物的0.05至20重量份与至少一种天然橡胶或合成橡胶组成的橡胶组分的100重量份混合制备而成，其中A表示选自芳香族基团，该基团可能带有取代基，咪唑环，该环可能带有取代基，以及具有1至18个碳原子的饱和或不饱和线性碳氢化合物中的一种；Y表示氢，氨基，具有1至18个碳原子的烷基，环烷基，烯基，芳香族基团，吡啶基或肼基；R1到R11分别表示氢，具有1至18个碳原子的烷基，环烷基或芳香族基团。并且使用该橡胶组合物制备的气动轮胎。
• RUBBER COMPOSITION AND PNEUMATIC TIRES
  申请人：Bridgestone Corporation

  公开号：EP0909788A1

  公开（公告）日：1999-04-21

  A rubber composition prepared by compounding 0.05 to 20 parts by weight of at least one selected from substituted hydrazide compounds represented by the following Formulas (I) to (IV) per 100 parts by weight of a rubber component comprising at least one rubber selected from the group consisting of natural rubber and synthetic rubber, and a pneumatic tire using the same: wherein A represents one selected from the group consisting of an aromatic group which may have a substituent, a hydantoin ring which may have a substituent, and a saturated or unsaturated linear hydrocarbon having 1 to 18 carbon atoms; Y represents hydrogen, an amino group, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group, an alkenyl group, an aromatic group, a pyridyl group or hydrazino group; and R1 to R11 each represent hydrogen, an alkyl group having 1 to 18 carbon atoms, a cycloalkyl group or an aromatic group.

  一种橡胶组合物，其制备方法是每 100 重量份由至少一种选自天然橡胶和合成橡胶组的橡胶组成的橡胶组分中混入 0.05 至 20 重量份的至少一种选自下式(I)至(IV)所代表的取代酰肼化合物，以及使用该组合物的充气轮胎： 其中 A 代表选自芳香基团（可具有取代基）、海因环（可具有取代基）和具有 1 至 18 个碳原子的饱和或不饱和线性烃；Y 代表氢、氨基、具有 1 至 18 个碳原子的烷基、环烷基、烯基、芳香基、吡啶基或肼基；R1 至 R11 分别代表氢、具有 1 至 18 个碳原子的烷基、环烷基或芳香基。
• Rubber composition and pneumatic tire
  申请人：Bridgestone Corporation

  公开号：EP1420044A2

  公开（公告）日：2004-05-19

  A hydrazone derivative represented by Formula (V):         ZC(=O)NHN=C(CH3) (CH2CH(CH3)2)     (V) wherein Z represents 3-hydroxy-2-naphthyl, 1-hydroxy-2-naphthyl, 2-hydroxyphenyl or 2,6-dihydroxyphenyl group.

  式 (V) 所代表的腙衍生物： ZC(=O)NHN=C(CH3) (CH2CH(CH3)2) (V) 其中 Z 代表 3-羟基-2-萘基、1-羟基-2-萘基、2-羟基苯基或 2,6-二羟基苯基。
• Synthesis and urease inhibitory potential of benzophenone sulfonamide hybrid in vitro and in silico
  作者：Arshia、Farida Begum、Noor Barak Almandil、Muhammad Arif Lodhi、Khalid Mohammed Khan、Abdul Hameed、Shahnaz Perveen

  DOI：10.1016/j.bmc.2019.01.043

  日期：2019.3

  This study deals with the synthesis of benzophenone sulfonamides hybrids (1-31) and screening against urease enzyme in vitro. Studies showed that several synthetic compounds were found to have good urease enzyme inhibitory activity. Compounds 1 (N'-((4'-hydroxyphenyl)(phenyl)methylene)-4 ''-nitrobenzenesulfonohy-drazide), 2 (N'-((4'-hydroxyphenyl)(phenyl)methylene)-3 ''-nitrobenzenesulfonohydrazide), 3 (N'-((4'-hydroxyphenyl)(phenyl)methylene)-4 ''-methoxybenzenesulfonohydrazide), 4 (3 '',5 ''-dichloro-2 ''-hydroxy-N'-((4'-hydroxyphenyl)(phenyl)methylene)benzenesulfonohydrazide), 6 (2 '',4 ''-dichloro-N'-((4'-hydroxyphenyl)(phenyl)methylene)benzenesulfonohydrazide), 8 (5-(dimethylamino)-N'-((4-hydroxyphenyl)(phenyel)methylene)naphthalene-1-sulfono hydrazide), 10 (2 ''-chloro-N'-((4'-hydroxyphenyl)(phenyl)methylene)benzenesulfonohydrazide), 12 (N'-((4'-hydroxyphenyl)(phenyl)methylene)benzenesulfonohydrazide) have found to be potently active having an IC50, value in the range of 3.90-17.99 mu M. These compounds showed superior activity than standard acetohydroxamic acid (IC50 = 29.20 +/- 1.01 mu M). Moreover, in silico studies on most active compounds were also performed to understand the binding interaction of most active compounds with active sites of urease enzyme. Structures of all the synthetic compounds were elucidated by H-1 NMR, C-13 NMR, EI-MS and FAB-MS spectroscopic techniques.
• Dornow; Bartsch, Justus Liebigs Annalen der Chemie, 1957, vol. 602, p. 23,32
  作者：Dornow、Bartsch

  DOI：——

  日期：——