methyl 2-chloro-4-(isobutylamino)pyrimidine-5-carboxylate | 1332708-02-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: methyl 2-chloro-4-(isobutylamino)pyrimidine-5-carboxylate
• CAS: 1332708-02-7
• 化学式: C₁₀H₁₄ClN₃O₂
• 分子量: 243.693
• InChiKey: MTRLHGLGMORNMM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.98
• 重原子数：
  16.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  64.11
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  methyl 2-chloro-4-(isobutylamino)pyrimidine-5-carboxylate 在 水 、 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 、 sodium hydroxide 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 8.0h， 生成 2-(4-benzylpiperazin-1-yl)-4-(2-methylpropylamino)-N-(pyridin-3-ylmethyl)pyrimidine-5-carboxamide
  参考文献：
  名称：

  Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

  摘要：

  TrpA1 is an ion channel involved in nociceptive and inflammatory pain. It is implicated in the detection of chemical irritants through covalent binding to a cysteine-rich intracellular region of the protein. While performing an HTS of the Pfizer chemical collection, a class of pyrimidines emerged as a non-reactive, non-covalently binding family of agonists of the rat and human TrpA1 channel. Given the issues identified with the reference agonist Mustard Oil (MO) in screening, a new, non-covalently binding agonist was optimized and proved to be a superior agent to MO for screening purposes. Compound 16a (PF-4840154) is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.035
• 作为产物：
  描述：

  2,4-二氯-5-嘧啶甲酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 生成 methyl 2-chloro-4-(isobutylamino)pyrimidine-5-carboxylate
  参考文献：
  名称：

  Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

  摘要：

  TrpA1 is an ion channel involved in nociceptive and inflammatory pain. It is implicated in the detection of chemical irritants through covalent binding to a cysteine-rich intracellular region of the protein. While performing an HTS of the Pfizer chemical collection, a class of pyrimidines emerged as a non-reactive, non-covalently binding family of agonists of the rat and human TrpA1 channel. Given the issues identified with the reference agonist Mustard Oil (MO) in screening, a new, non-covalently binding agonist was optimized and proved to be a superior agent to MO for screening purposes. Compound 16a (PF-4840154) is a potent, selective agonist of the rat and human TrpA1 channel and elicited TrpA1-mediated nocifensive behaviour in mouse. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.06.035