5-[(4-Ethoxyphenyl)amino]-2-methylbenzothiazole-4,7-dione

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 5-[(4-Ethoxyphenyl)amino]-2-methylbenzothiazole-4,7-dione
• 英文别名: 5-(4-ethoxyanilino)-2-methyl-1,3-benzothiazole-4,7-dione
• 化学式: C₁₆H₁₄N₂O₃S
• 分子量: 314.365
• InChiKey: SHUIJWVREWGXKR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  96.5
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  对乙氧基苯胺 、 5-甲氧基-2-甲基-4,7-苯并噻唑二酮 以 乙醇 为溶剂， 以85%的产率得到5-[(4-Ethoxyphenyl)amino]-2-methylbenzothiazole-4,7-dione
  参考文献：
  名称：

  5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents

  摘要：

  5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines, (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(00)00014-7

文献信息

• Synthesis and antifungal activities of 5/6-arylamino-4,7-dioxobenzothiazoles
  作者：Chung-Kyu Ryu、Hye-Young Kang、Yu-Jin Yi、Keun-Hwa Shin、Byung-Hoon Lee

  DOI：10.1016/s0960-894x(00)00301-2

  日期：2000.7

  5/6-Arylamino-4,7 -dioxobenzothiazoles were synthesized and tested for in vitro antifungal activities against pathogenic fungi. Most of the tested 4,7-dioxobenzothiazoles exhibited potent antifungal activities against Candida species and Aspergillus niger (C) 2000 Elsevier Science Ltd. All rights reserved.
• 5-Arylamino-2-methyl-4,7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents
  作者：Chung-Kyu Ryu、Hye-Young Kang、Sang Kook Lee、Kyung Ae Nam、Chang Yong Hong、Won-Gil Ko、Byung-Hoon Lee

  DOI：10.1016/s0960-894x(00)00014-7

  日期：2000.3

  5-Arylamino-2-methyl-4,7-dioxobenzothiazoles were synthesized as inhibitors of cyclin-dependent kinase 4 (CDK4) and cytotoxic agents. Most of the 4,7-dioxobenzothiazoles exhibited selective inhibitory activities for the CDK4 and cytotoxic potential against human cancer cell lines, (C) 2000 Elsevier Science Ltd. All rights reserved.