1-Phenylpyrido<3,4-d>pyridazin-4(3H)-one | 154865-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 1-Phenylpyrido<3,4-d>pyridazin-4(3H)-one
• 英文别名: 1-Phenyl-3H-pyrido[3,4-d]pyridazin-4-one
• CAS: 154865-52-8
• 化学式: C₁₃H₉N₃O
• 分子量: 223.234
• InChiKey: TWXDDLXHTYHDHZ-UHFFFAOYSA-N

物化性质

• 密度：
  1.33±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  碘乙烷 、 1-Phenylpyrido<3,4-d>pyridazin-4(3H)-one 在 氢氧化钾 作用下， 生成 3-ethyl-1-phenylpyrido[3,4-d]pyridazin-4-one
  参考文献：
  名称：

  Application of organolithium and related reagents in synthesis, Part XII. Synthesis of phenyl- and pyridylpyridopyridazinones and their derivatives

  摘要：

  The preparation of the pyridazinones 10a, 10b, 11a, 11b, and 12a, 12b from the ketoamides 7,8, and 9 and hydrazine hydrate is described. It was found that from ketoamides 8b and 9b in addition to the expected pyridopyridazinones 11b and 12b also aminopyridopyridazines 14 and 15 were formed and that ketoamide 7b gave exclusively aminopyridopyridazine 13. The pyridopyridazinones 10b, 11b, and 12b were alkylated with alkyl iodides.

  DOI：

  10.1007/bf00819523
• 作为产物：
  描述：

  N,N-二甲基苯甲酰胺 在 一水合肼 、 lithium diisopropyl amide 作用下， 以 二乙二醇 为溶剂， 反应 5.5h， 生成 1-Phenylpyrido<3,4-d>pyridazin-4(3H)-one
  参考文献：
  名称：

  Application of organolithium and related reagents in synthesis, Part XII. Synthesis of phenyl- and pyridylpyridopyridazinones and their derivatives

  摘要：

  The preparation of the pyridazinones 10a, 10b, 11a, 11b, and 12a, 12b from the ketoamides 7,8, and 9 and hydrazine hydrate is described. It was found that from ketoamides 8b and 9b in addition to the expected pyridopyridazinones 11b and 12b also aminopyridopyridazines 14 and 15 were formed and that ketoamide 7b gave exclusively aminopyridopyridazine 13. The pyridopyridazinones 10b, 11b, and 12b were alkylated with alkyl iodides.

  DOI：

  10.1007/bf00819523

文献信息

• A New and Convenient Synthesis of 3-Aryl-3-hydroxyisoindol-1-ones and Their Aza Analogs
  作者：Yuko Saito、Takeshi Sakamoto、Yasuo Kikugawa

  DOI：10.1055/s-2001-10804

  日期：——

  A simple and convenient synthesis of 3-aryl-3-hydroxyisoindol-1-ones and their aza analogs is described. The utility of this synthesis is demonstrated by the preparation of 4-arylphthalazinones and their aza analogs.

  本文介绍了一种简单方便的 3-芳基-3-羟基异吲哚-1-酮及其氮杂类似物的合成方法。通过制备 4-芳基酞嗪酮及其氮杂类似物，证明了这种合成方法的实用性。