1-oxidopyridin-3-yl acetate | 29487-15-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-oxidopyridin-3-yl acetate
• 英文别名: 3-acetoxypyridine 1-oxide；3-Acetoxypyridine1-oxide；(1-oxidopyridin-1-ium-3-yl) acetate
• CAS: 29487-15-8
• 化学式: C₇H₇NO₃
• 分子量: 153.137
• InChiKey: JEOPBWIPRLKYQI-UHFFFAOYSA-N

物化性质

• 沸点：
  349.6±15.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-oxidopyridin-3-yl acetate 在 sodium hydroxide 、 乙酸酐 、 三乙胺 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 2-(1-adamantylthio)-3-pyridinol
  参考文献：
  名称：

  Prachayasittikul, Sulpaluk; Doss, George; Bauer, Ludwig, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 1051 - 1060

  摘要：

  DOI：
• 作为产物：
  描述：

  3-乙酰氧基吡啶 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以15%的产率得到1-oxidopyridin-3-yl acetate
  参考文献：
  名称：

  Efficient Chemoenzymatic Dynamic Kinetic Resolution of 1-Heteroaryl Ethanols

  摘要：

  The scope and limitation of the combined rutheinum-lipase induced dynamic kinetic resolution (DKR) through O-acetylation of racemic heteroaromatic secondary alcohols, i.e., 1-heteroaryl substituted ethanols, was investigated. After initial screening of reaction conditions, Candida antarctica lipase B (Novozyme 435, N435) together with 4-chloro-phenylacetate as acetyl-donor for kinetic resolution (KR), in conjunction with the ruthenium-based Shvo catalyst for substrate racemization in toluene at 80 degrees C, enabled DKR with high yields and stereoselectivity of various 1-heteroaryl ethanols, Such as oxadiazoles, isoxazoles, 1H-pyrazole, or 1H-imidazole. In addition, DFT calculations based on a simplified catalyst complex model for the catalytic (de)hydrogenation step are in agreement with the previously reported outer sphere mechanism. These results support the further understanding of the mechanistic aspects behind the difference in reactivity of 1-heteroaryl substituted ethanols in comparison to reference substrates, as often referred to in the literature.

  DOI：

  10.1021/jo901987z

文献信息

• Efficient Chemoenzymatic Dynamic Kinetic Resolution of 1-Heteroaryl Ethanols
  作者：Karl S. A. Vallin、David Wensbo Posaric、Zdenko Hameršak、Mats A. Svensson、Alexander B. E. Minidis

  DOI：10.1021/jo901987z

  日期：2009.12.18

  The scope and limitation of the combined rutheinum-lipase induced dynamic kinetic resolution (DKR) through O-acetylation of racemic heteroaromatic secondary alcohols, i.e., 1-heteroaryl substituted ethanols, was investigated. After initial screening of reaction conditions, Candida antarctica lipase B (Novozyme 435, N435) together with 4-chloro-phenylacetate as acetyl-donor for kinetic resolution (KR), in conjunction with the ruthenium-based Shvo catalyst for substrate racemization in toluene at 80 degrees C, enabled DKR with high yields and stereoselectivity of various 1-heteroaryl ethanols, Such as oxadiazoles, isoxazoles, 1H-pyrazole, or 1H-imidazole. In addition, DFT calculations based on a simplified catalyst complex model for the catalytic (de)hydrogenation step are in agreement with the previously reported outer sphere mechanism. These results support the further understanding of the mechanistic aspects behind the difference in reactivity of 1-heteroaryl substituted ethanols in comparison to reference substrates, as often referred to in the literature.
• Prachayasittikul, Sulpaluk; Doss, George; Bauer, Ludwig, Journal of Heterocyclic Chemistry, 1991, vol. 28, # 4, p. 1051 - 1060
  作者：Prachayasittikul, Sulpaluk、Doss, George、Bauer, Ludwig

  DOI：——

  日期：——