2,3,6-三溴苯甲酸 | 21739-99-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2,3,6-三溴苯甲酸
• 英文名称: 2,3,6-tribromobenzoic acid
• CAS: 21739-99-1
• 化学式: C₇H₃Br₃O₂
• 分子量: 358.812
• InChiKey: IUCILSOWKNCUOC-UHFFFAOYSA-N

物化性质

• 沸点：
  381.3±42.0 °C(Predicted)
• 密度：
  2.383±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,3,6-三溴苯甲酸 在 copper aluminum 氘氧化钠 作用下， 反应 0.5h， 生成 benzoic-2,3,6-d3 acid
  参考文献：
  名称：

  Tashiro, Masashi; Nakayama, Kouji; Fukata, Gouki, Journal of the Chemical Society. Perkin transactions I, 1983, # 10, p. 2315 - 2318

  摘要：

  DOI：
• 作为产物：
  描述：

  1,3-二溴-2-(三甲基甲硅烷基)苯 在 正丁基锂 、 溴 、 (tert-butyldimethylsilyl)-tert-butylamine 作用下， 以 四氢呋喃 、 四氯化碳 为溶剂， 反应 96.0h， 生成 2,3,6-三溴苯甲酸
  参考文献：
  名称：

  Mongin, Florence; Marzi, Elena; Schlosser, Manfred, European Journal of Organic Chemistry, 2001, # 14, p. 2771 - 2777

  摘要：

  DOI：

文献信息

• Preparation of aromatic and heteroaromatic carboxylic acids by catalytic ozonolysis
  申请人：——

  公开号：US20030216577A1

  公开（公告）日：2003-11-20

  A process for catalytically oxidizing alkylaromatic compounds of the formula (I) Ar—CH 2 —R where Ar is an optionally substituted, aromatic or heteroaromatic 5-membered or 6-membered ring or a ring system having up to 20 carbon atoms where Ar may optionally be fused to a C 1 -C 6 -alkyl group in which up to 2 carbon atoms may be replaced by a heteroatom, and R is hydrogen, phenyl, benzyl or heteroaryl, where the phenyl, benzyl or heteroaryl radicals may also be joined to Ar by a bridge, or R together with Ar forms an optionally substituted ring system which may contain one or more optionally substituted heteroatoms, to the corresponding aromatic or heteroaromatic carboxylic acids in a solvent with ozone in the presence of a transition metal catalyst and optionally in the presence of an acid at a temperature between −70° C. and 110° C. to the corresponding carboxylic acid.

  将式(I)中的烷基芳香化合物催化氧化为相应的芳香或杂芳羧酸的过程是在溶剂中，在存在过渡金属催化剂和可选地存在酸的情况下，利用臭氧将式(I)中的化合物氧化为相应的芳香或杂芳羧酸的过程。其中，式(I)中Ar为可选地取代的芳香或杂芳5-或6-成员环或具有多达20个碳原子的环系统，其中Ar可选地与一个C1-C6-烷基基团融合，其中最多有2个碳原子可被杂原子取代；R为氢、苯基、苄基或杂芳基，其中苯基、苄基或杂芳基基团也可以通过桥连接到Ar，或R与Ar一起形成一个可选地取代的环系统，该环系统可以含有一个或多个可选地取代的杂原子，反应温度在-70°C至110°C之间。
• HIGH YIELD SYNTHESIS METHODS FOR PRODUCING ORGANIC SALTS OF STRONTIUM
  申请人：Christgau Stephan

  公开号：US20090137678A1

  公开（公告）日：2009-05-28

  New organic salts of strontium and methods of synthesizing such salts with high purity, high yields and with short processing times, at neutral conditions and at low reaction temperature, such as a temperature at or below 50° C.

  新的锶有机盐及合成这种盐的方法，具有高纯度、高产率、短处理时间，在中性条件下以及低反应温度，如在50°C或以下的温度下。
• [EN] STRONTIUM-CONTAINING COMPOUNDS FOR USE IN THE PREVENTION OR TREATMENT OF NECROTIC BONE CONDITIONS<br/>[FR] COMPOSES A BASE DE STRONTIUM DESTINES A ETRE UTILISES DANS LA PREVENTION OU LE TRAITEMENT DE CONDITIONS D'OS NECROTIQUES
  申请人：OSTEOLOGIX AS

  公开号：WO2005082385A1

  公开（公告）日：2005-09-09

  A method for the treatment and/or prophylaxis of an ostenonecrotic bone disease in a mammal in need thereof, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis, Legg-Calve-Perthes disease and femoral head necrosis, the method comprising administering an effective dose of a strontium-containing compound (a) to the mammal. A method for the treatment and/or prophylaxis of an osteonecrotic bone disease, such as, e.g., idiopathic or secondary osteonecrosis, avascular bone necrosis, glucocorticoid induced bone ischemia/osteonecrosis and femoral head necrosis, in a mammal who is to be or is treated with a therapeutic agent (b) known to or suspected of inducing apoptosis and/or necrosis of bone cells, the method comprising administering a strontium-containing compound (a) in combination with (b).

  一种治疗和/或预防哺乳动物骨骼坏死性疾病的方法，例如特发性或继发性骨坏死、无血管性骨坏死、糖皮质激素诱导的骨缺血/骨坏死、莱格-卡尔韦-佩尔特斯病和股骨头坏死，该方法包括向哺乳动物投予含锶化合物（a）的有效剂量。一种治疗和/或预防骨骼坏死性疾病的方法，例如特发性或继发性骨坏死、无血管性骨坏死、糖皮质激素诱导的骨缺血/骨坏死和股骨头坏死，在将要或正在接受已知或疑似诱导骨细胞凋亡和/或坏死的治疗剂（b）的哺乳动物中，该方法包括给予含锶化合物（a）与（b）的组合。
• High shear process for making metallic esters
  申请人：Dover Chemical Corporation

  公开号：EP1604969A1

  公开（公告）日：2005-12-14

  A process to make a metallic ester which comprises: (a) mixing at least one metallic salt with at least one partially heated acidic organic moiety form a heated slurry at a first temperature; (b) reacting said slurry under shear conditions to form a micro-emulsion for no longer than about two minutes at a second higher temperature to form a pumpable metallic ester; and (c) collecting said metallic ester.

  制备金属酯的过程包括：(a)将至少一种金属盐与至少一种部分加热的酸性有机基团混合形成一个在第一温度下加热的浆料；(b)在第二较高温度下，在剪切条件下反应该浆料，形成一个微乳液，反应时间不超过约两分钟，以形成可泵送的金属酯；(c)收集所述金属酯。
• High Yield And Rapid Synthesis Methods For Producing Metallo-Organic Salts
  申请人：Christgau Stephan

  公开号：US20070282127A1

  公开（公告）日：2007-12-06

  A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

  一种制备金属阳离子和有机酸盐的新方法，特别是来自周期表II组的碱土金属离子的二价盐和羧酸。该方法包括使用高温（约90℃或更高）和可选的高压，以获得比已知合成方法更高的产量、纯度和更快的反应速度。特别是，本发明涉及羧酸锶盐的生产。本方法还提供了新型锶盐。