(1-methylcyclopropyl) N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate | 1310458-29-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-methylcyclopropyl) N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate
• CAS: 1310458-29-7
• 化学式: C₁₈H₂₄N₂O₃
• 分子量: 316.4
• InChiKey: VBXRNWXGBXIVIO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (1-methylcyclopropyl) N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate 在 氢溴酸 作用下， 以 水 、 溶剂黄146 为溶剂， 反应 48.0h， 生成 (4-Amino-1-piperidinyl)(4-methylphenyl)methanone
  参考文献：
  名称：

  The (1-methyl)cyclopropyloxycarbonyl (MPoc) carbamate: a new protecting group for amines

  摘要：

  The (1-methyl)cyclopropyl carbamate (MPoc) group represents a new and useful protecting group for amines. It adds relatively little molecular weight and has a simple (1)H NMR spectrum. It is orthogonal to the commonly used BOC, Cbz, Alloc, and FMOC groups. MPoc protected amines are resistant to extremes of pH, amines, halogens, many oxidizing agents, and to hydrogenation at ambient temperature. The MPoc group is cleaved by exposure to hypobromous acid or upon hydrogenolysis over palladium at 80 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.027
• 作为产物：
  描述：

  (1-甲基环丙基)(4-硝基苯基)碳酸酯 、 (4-Amino-1-piperidinyl)(4-methylphenyl)methanone 以 二氯甲烷 为溶剂， 以89%的产率得到(1-methylcyclopropyl) N-[1-(4-methylbenzoyl)piperidin-4-yl]carbamate
  参考文献：
  名称：

  The (1-methyl)cyclopropyloxycarbonyl (MPoc) carbamate: a new protecting group for amines

  摘要：

  The (1-methyl)cyclopropyl carbamate (MPoc) group represents a new and useful protecting group for amines. It adds relatively little molecular weight and has a simple (1)H NMR spectrum. It is orthogonal to the commonly used BOC, Cbz, Alloc, and FMOC groups. MPoc protected amines are resistant to extremes of pH, amines, halogens, many oxidizing agents, and to hydrogenation at ambient temperature. The MPoc group is cleaved by exposure to hypobromous acid or upon hydrogenolysis over palladium at 80 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.04.027

文献信息

• The (1-methyl)cyclopropyloxycarbonyl (MPoc) carbamate: a new protecting group for amines
  作者：Erik J. Snider、Stephen W. Wright

  DOI：10.1016/j.tetlet.2011.04.027

  日期：2011.6

  The (1-methyl)cyclopropyl carbamate (MPoc) group represents a new and useful protecting group for amines. It adds relatively little molecular weight and has a simple (1)H NMR spectrum. It is orthogonal to the commonly used BOC, Cbz, Alloc, and FMOC groups. MPoc protected amines are resistant to extremes of pH, amines, halogens, many oxidizing agents, and to hydrogenation at ambient temperature. The MPoc group is cleaved by exposure to hypobromous acid or upon hydrogenolysis over palladium at 80 degrees C. (C) 2011 Elsevier Ltd. All rights reserved.