o-benzoylbenzohydrazide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: o-benzoylbenzohydrazide
• 英文别名: Benzoyl-benzohydrazide；2-benzoylbenzohydrazide
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: MWRAOTMSRPJWMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  72.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  o-benzoylbenzohydrazide 在 盐酸 作用下， 生成 4-苯基-1(2H)-酞嗪酮
  参考文献：
  名称：

  Ismail, Mohamed Fekry; Kandile, Nadia Gharib, Acta Chimica Hungarica, 1991, vol. 128, # 2, p. 251 - 253

  摘要：

  DOI：
• 作为产物：
  描述：

  邻苯甲酰苯甲酸 在 硫酸 、 一水合肼 作用下， 以 乙醇 为溶剂， 反应 4.67h， 生成 o-benzoylbenzohydrazide
  参考文献：
  名称：

  Design, characterization, computational studies, and pharmacological evaluation of substituted-N′-[(1E) substituted-phenylmethylidene]benzohydrazide analogs

  摘要：

  A series of substituted-N'-[(1E)-substituted-phenylmethylidene]benzohydrazide analogs were synthesized and authenticated by TLC, UV-Visible, FTIR, and NMR spectroscopic techniques. The physicochemical similarity of the new analogs with standard drugs was assessed by calculating from a set of ten physicochemical properties using software programs. The information so obtained can be related to prediction of biological activity for important targets. All the target compounds 4a-n were evaluated for their antioxidant, anti-inflammatory, and antimicrobial activity using different in vitro models. The test compounds demonstrated good similarity values with respect to the standard drugs. The compounds 4c, 4d, and 4e have emerged as important lead compounds showing potential anti-inflammatory; and 4b, 4f, and 4c having antioxidant profile. While studying MIC against bacterial strains 4c, 4f, 4i, 4k, and 4m were most active among all the target compounds. All compounds were found to have very good antifungal activity. The compounds having nitro substitution at the arylidene moiety i.e., 4c and 4f showed the most potent antifungal as well as antibacterial activities. While studying total antioxidant activity, all target compounds were found to have good antioxidant activity.

  DOI：

  10.1007/s00044-012-0270-0

文献信息

• RUBBER COMPOSITION AND VULCANIZATION AID
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20170130028A1

  公开（公告）日：2017-05-11

  A rubber composition comprising a compound having one or more groups represented by formula (X) and a rubber component is provided. wherein ring W 1 represents a cyclic group having at least one selected from the group consisting of —C(═O)— and —C(═S)—; N 10 represents a nitrogen atom; the at least one selected from the group consisting of —C(═O)— and —C(═S)— in the ring W 1 and N 10 are conjugated; and Z 1 represents —O— or —S—.

  提供一种橡胶组合物，包括具有一个或多个由式（X）表示的基团和橡胶组分，其中环W1代表具有至少一种从羰基和硫代基组成的群中选出的环；N10代表氮原子；环W1和N10中所选的至少一种从羰基和硫代基组成的群是共轭的；Z1代表氧或硫。
• RUBBER COMPOSITION
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：US20150251992A1

  公开（公告）日：2015-09-10

  A rubber composition obtained by kneading at least one selected from the group consisting of (A1), (B1), (C1) and (D1), a rubber component and a filler, and a method of improving the viscoelastic property of vulcanized rubber, comprising a first step of kneading at least one selected from the group consisting of (A1), (B1), (C1) and (D1), a rubber component, a filler and a sulfur component and a second step of thermally treating the kneaded material obtained in the previous step. (A1): a compound represented by formula (I) (B1): a salt of a compound represented by formula (I) (C1): a solvate of a compound represented by formula (I) (D1): a solvate of a salt of a compound represented by formula (I)

  通过将至少从(A1)、(B1)、(C1)和(D1)组成的群体中选择的至少一种、橡胶成分和填料混炼而得到的橡胶组合物，以及一种改善硫化橡胶的粘弹性能的方法，包括第一步骤：混炼至少从(A1)、(B1)、(C1)和(D1)组成的群体中选择的至少一种、橡胶成分、填料和硫化物成分，以及第二步骤：对在前一步骤中获得的混炼材料进行热处理。(A1)：由式(I)表示的化合物(B1)：由式(I)表示的化合物的盐(C1)：由式(I)表示的化合物的溶剂(D1)：由式(I)表示的化合物的盐的溶剂
• RAF KINASE MODULATOR COMPOUNDS AND METHODS OF USE THEREOF
  申请人：Abraham Sunny

  公开号：US20110118245A1

  公开（公告）日：2011-05-19

  Compounds according to formula (I), compositions and methods are provided for modulating the activity of RAF kinases, including BRAF kinase and for the treatment, prevention, or amelioration of one or more symptoms of disease or disorder mediated by RAF kinases. Formula (I): or a pharmaceutically acceptable salt, solvate, clathrate of hydrate thereof, wherein X is O or S(O) t ; R a is O or S.

  提供了按照公式(I)的化合物、组合物和方法，用于调节RAF激酶的活性，包括BRAF激酶，并用于治疗、预防或缓解由RAF激酶介导的一种或多种疾病或障碍的症状。公式(I)：或其药学上可接受的盐、溶剂化合物、包合物或水合物，其中X为O或S(O)t；R为O或S。
• METHOD FOR LOWERING DYNAMIC-TO-STATIC MODULUS RATIO OF VULCANIZED RUBBER
  申请人：Uekita Yasuo

  公开号：US20140142217A1

  公开（公告）日：2014-05-22

  A method for lowering the dynamic-to-static modulus ratio of vulcanized rubber, the method comprising a first step of kneading a rubber component, a filler and a compound represented by formula (I) or a salt thereof, a second step of kneading the kneaded mixture obtained in the first step, a sulfur component and a vulcanization accelerator, and a third step of thermally treating the kneaded mixture obtained in the second step, in formula (I), n represents an integer of 0 to 10. The compound represented by formula (I) or a salt thereof is preferably S-(3-aminopropyl)thiosulfuric acid or a salt thereof.

  一种降低硫化橡胶动态与静态模量比的方法，该方法包括第一步：将橡胶组分、填料和化合物(I)或其盐混合揉捏；第二步：将第一步所得到的混合物、硫组分和硫化促进剂混合揉捏；第三步：对第二步所得到的混合物进行热处理。在公式(I)中，n表示0到10的整数。化合物(I)或其盐最好是S-(3-氨基丙基)硫酸或其盐。
• METHOD FOR USING S-(3-AMINOPROPYL)THIOSULFURIC ACID AND/OR METAL SALT THEREOF
  申请人：Sumitomo Chemical Company Limited

  公开号：EP2589619A1

  公开（公告）日：2013-05-08

  A method for using S-(3-aminopropyl)thiosulfuric acid and/or a metal salt thereof added to a rubber component as a raw material of a vulcanized rubber composition, comprising a pre-kneading step A of kneading a rubber component, a filler, S-(3-aminopropyl)thiosulfuric acid and/or a metal salt thereof, a post-kneading step B of kneading the kneaded substance A obtained in the pre-kneading step A, a sulfur component, and a vulcanization accelerator having a weight over the weight of the above-described sulfur component, and a thermal treatment step C of thermally-treating the kneaded substance B obtained in the post-kneading step B to obtain a vulcanized rubber composition, wherein durability is imparted to the vulcanized rubber composition;

  一种使用添加到橡胶成分中的 S-(3-氨基丙基)硫代硫酸和/或其金属盐作为硫化橡胶组合物原料的方法，包括 捏合橡胶成分、填充剂、S-(3-氨基丙基)硫代硫酸和/或其金属盐的预捏合步骤 A、 后捏合步骤 B：捏合在预捏合步骤 A 中得到的捏合物 A、硫磺成分和硫化促进剂，硫化促进剂的重量超过上述硫磺成分的重量，以及 热处理步骤 C：对在后捏合步骤 B 中得到的捏合物 B 进行热处理，以得到硫化橡胶组合物，其中赋予硫化橡胶组合物耐久性；